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Open Access 01-12-2019 | Leukocytoclastic Vasculitis | Case report

Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody panitumumab: a case report

Authors: Hitomi Kamo, Eiji Shinozaki, Takanobu Sugase, Nobuyuki Mizunuma, Shoji Taniguchi, Takashi Gotoh, Keisyo Chin, Tomoaki Tanaka, Kazumi Koga, Kensei Yamaguchi

Published in: Journal of Medical Case Reports | Issue 1/2019

Abstract

Background

Panitumumab is the first human combinatorial antibody for the treatment of metastatic colorectal carcinoma. Dermatologic toxicity of all grades occurs in more than 90% of patients. However, there are few reports of purpura induced by anti-epidermal growth factor receptor antibody. Renal failure is also uncommon as an adverse event of anti-epidermal growth factor receptor antibody.

Case presentation

A 67-year-old Japanese man with advanced colon cancer received monotherapy with panitumumab. General malaise, bilateral edema of his legs, and bilateral purpura of his forearms developed 2 days after the second cycle of panitumumab. A skin biopsy was performed to evaluate the purpuric lesions on his left leg and leukocytoclastic vasculitis was diagnosed. Blood tests showed grade III acute renal failure with a blood urea nitrogen level of 33.8 mg/dL and a creatinine level of 3.10 mg/dL.

Conclusions

This is the first reported case of leukocytoclastic vasculitis followed by purpura and acute renal failure associated with panitumumab.

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Title: Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody panitumumab: a case report
Authors: Hitomi Kamo
Eiji Shinozaki
Takanobu Sugase
Nobuyuki Mizunuma
Shoji Taniguchi
Takashi Gotoh
Keisyo Chin
Tomoaki Tanaka
Kazumi Koga
Kensei Yamaguchi
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Leukocytoclastic Vasculitis
Leukocytoclastic Vasculitis
Edema
Cetuximab
Panitumumab
Colon Cancer
Colon Cancer
Published in: Journal of Medical Case Reports / Issue 1/2019
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-018-1877-7

At a glance: The STEP trials

Springer Medicine

Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody panitumumab: a case report

Abstract

Background

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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