Top

Published in:

01-10-2018 | Letter to the Editor

Letter to the Editor: Response to Cox (2018)

Authors: Teresa Gavaruzzi, Alessandra Tasso, Marzena Franiuk, Liliana Varesco, Lorella Lotto

Published in: Journal of Genetic Counseling | Issue 5/2018

Excerpt

This letter is in response to the comment by Cox (2018), who appeared to be concerned by the figures we presented to participants about the residual risk for ovarian cancer after bilateral risk-reducing salpingo-oophorectomy (RRSO). We agree with the fact that the presence of a residual cancer risk after prophylactic surgery is an important element of discussion during post-test genetic counseling and the subsequent decision-making process. However, at present, we don’t have robust evidence of these figures in real-life high-risk programs. For this reason, we decided to take a conservative approach and, as hypothesized by Cox, we used “…the 80% reduction in risk for ovarian cancer reported in Finch et al. (2014), in conjunction with the lifetime risks reported by Mavaddat et al. (2013)”, instead of using lower figures. …

Cameron, L. D., Sherman, K. A., Marteau, T. M., & Brown, P. M. (2009). Impact of genetic risk information and type of disease on perceived risk, anticipated affect, and expected consequences of genetic tests. Health Psychology, 28, 307–316.CrossRefPubMed

Cox, D. (2018). Letter to the Editor: Response to “A psychological perspective on factors predicting prophylactic salpingo-oophorectomy in a sample of Italian women from the general population. Results from a hypothetical study in the context of BRCA mutations.” Journal of Genetic Counseling. https://doi.org/10.1007/s10897-018-0280-2.CrossRefPubMed

Finch, A. P., Lubinski, J., Møller, P., Singer, C. F., Karlan, B., Senter, L., et al. (2014). Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. Journal of Clinical Oncology, 32, 1547–1553.CrossRefPubMedPubMedCentral

Gavaruzzi, T., Tasso, A., Franiuk, M., Varesco, L., & Lotto, L. (2017). A psychological perspective on factors predicting prophylactic salpingo-oophorectomy in a sample of Italian women from the general population. Results from a hypothetical study in the context of BRCA mutations. Journal of Genetic Counseling, 26, 1144–1152.CrossRefPubMed

Gigerenzer, G., Gaissmaier, W., Kurz-Milcke, E., Schwartz, L. M., & Woloshin, S. (2007). Helping doctors and patients make sense of health statistics. Psychological Science in the Public Interest, 8, 53–96.CrossRefPubMed

Kahneman, D., & Tversky, A. (1979). Prospect theory: An analysis of decision under risk. Econometrica: Journal of the Econometric Society, 47, 263–291.CrossRef

Lotto, L., Tasso, A., Gavaruzzi, T., Carnaghi, A., & Rumiati, R. (2014). How framing and numerical information affect people’s judgments when they read a newspaper story. New Ideas in Psychology, 32, 33–41.CrossRef

Marchetti, C., De Felice, F., Palaia, I., Perniola, G., Musella, A., Musio, D., et al. (2014). Risk-reducing salpingo-oophorectomy: A meta-analysis on impact on ovarian cancer risk and all cause mortality in BRCA 1 and BRCA 2 mutation carriers. BMC Women’s Health, 14, 1–6.CrossRef

Mavaddat, N., Peock, S., Frost, D., Ellis, S., Platte, R., Fineberg, E., et al. (2013). Cancer risks for BRCA1 and BRCA2 mutation carriers: Results from prospective analysis of EMBRACE. Journal of the National Cancer Institute, 105, 812–822.CrossRefPubMed

Prelec, D. (1998). The probability weighting function. Econometrica: Journal of the Econometric Society, 66, 497–527.CrossRef

Reyna, V. F. (2008). A theory of medical decision making and health: Fuzzy trace theory. Medical Decision Making, 28, 850–865.CrossRefPubMedPubMedCentral

Reyna, V. F., & Brainerd, C. J. (1995). Fuzzy-trace theory: An interim synthesis. Learning and Individual Differences, 7, 1–75.CrossRef

Slovic, P., Finucane, M. L., Peters, E., & MacGregor, D. G. (2007). The affect euristic. European Journal of Operational Research, 177, 1333–1352.CrossRef

Witteman, H. O., Zikmund-Fisher, B. J., Waters, E. A., Gavaruzzi, T., & Fagerlin, A. (2011). Risk estimates from an online risk calculator are more believable and recalled better when expressed as integers. Journal of Medical Internet Research, 13, e54.CrossRefPubMedPubMedCentral

Title: Letter to the Editor: Response to Cox (2018)
Authors: Teresa Gavaruzzi
Alessandra Tasso
Marzena Franiuk
Liliana Varesco
Lorella Lotto
Publication date: 01-10-2018
Publisher: Springer US
Published in: Journal of Genetic Counseling / Issue 5/2018
Print ISSN: 1059-7700
Electronic ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-018-0279-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Letter to the Editor: Response to Cox (2018)

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 5/2018

Issue Highlights

Pregnant Women’s Perspectives on Expanded Carrier Screening

Exploring the Issues Surrounding Clinical Exome Sequencing in the Prenatal Setting

Reduction of Health Care Costs and Improved Appropriateness of Incoming Test Orders: the Impact of Genetic Counselor Review in an Academic Genetic Testing Laboratory

Pregnant Genetic Counselors in an Era of Advanced Genomic Tests: What Do the Experts Test Prenatally?

Involvement and Influence of Healthcare Providers, Family Members, and Other Mutation Carriers in the Cancer Risk Management Decision-Making Process of BRCA1 and BRCA2 Mutation Carriers