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Osteoporosis International

Published in:

01-02-2007 | Original Article

Leptin and bone turnover in monochorionic twins complicated by twin–twin transfusion syndrome

Authors: R. Bajoria, S. R. Sooranna, R. Chatterjee

Published in: Osteoporosis International | Issue 2/2007

Abstract

Introduction

To test the hypothesis that the bone metabolism of a growth-restricted foetus is regulated by genetic, placental and/or foetal factors through leptin, we investigated the foetal bone turnover in monochorionic pregnancies complicated with or without twin–twin transfusion syndrome (TTTS).

Methods

Maternal and cord bloods were collected from gestational-age-matched monochorionic twins with (n = 15) and without (n = 15) TTTS. The samples were assayed for leptin, cross-linked carboxyl terminal telo-peptide (ICTP, a marker of bone resorption) and pro-peptide (PICP, a marker of bone formation) of type I collagen by radioimmunoassay (RIA).

Results

In the growth-restricted donor twin, the plasma concentration of leptin (P < 0.001), PICP (P < 0.001) was lower, while that of ICTP (P < 0.001) was higher than the recipient twin of the TTTS group. In contrast, leptin, PICP and ICTP were comparable in non-TTTS twins. In the recipient twin of TTTS and non-TTTS twins, leptin was positively associated with PICP (r = 0.73; n = 45, P < 0.001) and negatively with ICTP (r = −0.68; n = 45; P < 0.001). No such association was found between leptin and bone marker in the growth-restricted donor twin of the TTTS group.

Conclusion

Our data suggest that, in AGA twins, leptin maintains bone metabolism by inhibiting resorption and enhancing bone formation. In contrast, growth-restricted donor twins have high bone turnover and this does not seem to be due to leptin deficiency.

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Title: Leptin and bone turnover in monochorionic twins complicated by twin–twin transfusion syndrome
Authors: R. Bajoria
S. R. Sooranna
R. Chatterjee
Publication date: 01-02-2007
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 2/2007
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0236-5

At a glance: The STEP trials

Springer Medicine

Leptin and bone turnover in monochorionic twins complicated by twin–twin transfusion syndrome

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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