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Journal of Cardiovascular Magnetic Resonance
Published in: Journal of Cardiovascular Magnetic Resonance 1/2013

Open Access 01-12-2013 | Research

Left ventricular reverse remodeling after transcatheter aortic valve implantation: a cardiovascular magnetic resonance study

Authors: Alessio La Manna, Alessandra Sanfilippo, Davide Capodanno, Antonella Salemi, Alessandra Cadoni, Irene Cascone, Gesualdo Polizzi, Michele Figuera, Rosetta Pittalà, Carmelo Privitera, Corrado Tamburino

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2013

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Abstract

Background

In patients with severe aortic stenosis, left ventricular hypertrophy is associated with increased myocardial stiffness and dysfunction linked to cardiac morbidity and mortality. We aimed at systematically investigating the degree of left ventricular mass regression and changes in left ventricular function six months after transcatheter aortic valve implantation (TAVI) by cardiovascular magnetic resonance (CMR).

Methods

Left ventricular mass indexed to body surface area (LVMi), end diastolic volume indexed to body surface area (LVEDVi), left ventricular ejection fraction (LVEF) and stroke volume (SV) were investigated by CMR before and six months after TAVI in patients with severe aortic stenosis and contraindications for surgical aortic valve replacement.

Results

Twenty-sevent patients had paired CMR at baseline and at 6-month follow-up (N=27), with a mean age of 80.7±5.2 years. LVMi decreased from 84.5±25.2 g/m2 at baseline to 69.4±18.4 g/m2 at six months follow-up (P<0.001). LVEDVi (87.2±30.1 ml /m2vs 86.4±22.3 ml/m2; P=0.84), LVEF (61.5±14.5% vs 65.1±7.2%, P=0.08) and SV (89.2±22 ml vs 94.7±26.5 ml; P=0.25) did not change significantly.

Conclusions

Based on CMR, significant left ventricular reverse remodeling occurs six months after TAVI.
Appendix
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Metadata
Title
Left ventricular reverse remodeling after transcatheter aortic valve implantation: a cardiovascular magnetic resonance study
Authors
Alessio La Manna
Alessandra Sanfilippo
Davide Capodanno
Antonella Salemi
Alessandra Cadoni
Irene Cascone
Gesualdo Polizzi
Michele Figuera
Rosetta Pittalà
Carmelo Privitera
Corrado Tamburino
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Cardiovascular Magnetic Resonance / Issue 1/2013
Electronic ISSN: 1532-429X
DOI
https://doi.org/10.1186/1532-429X-15-39

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