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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 5/2016

01-10-2016 | Original Article

Left ventricular metabolism, function, and sympathetic innervation in men and women with type 1 diabetes

Authors: Claire S. Duvernoy, MD, David M. Raffel, PhD, Scott D. Swanson, PhD, Mamta Jaiswal, MD, Gisela Mueller, MD, El-Sayed Ibrahim, PhD, Subramaniam Pennathur, MD, Cynthia Plunkett, RN, Jadranka Stojanovska, MD, Morton B. Brown, PhD, Rodica Pop-Busui, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 5/2016

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Abstract

Background

In type I diabetes (T1DM), alterations in LV function may occur due to changes in innervation, metabolism, and efficiency.

Objectives

We evaluated the association between sympathetic nerve function, oxidative metabolism, resting blood flow, LV efficiency and function in healthy diabetics, and assessed gender differences.

Methods

Cross-sectional study of 45 subjects with T1DM, 60% females, age 34 ± 13 years, and 10 age-matched controls. Positron emission tomography (PET) imaging with [11C]acetate and [11C]meta-hydroxyephedrine was performed, in addition to cardiac magnetic resonance imaging.

Results

There were no significant differences in LV function, innervation, or oxidative metabolism between T1DM and controls. Cardiac oxidative metabolism was positively associated with higher levels of sympathetic activation, particularly in women. Diabetic women had significantly lower efficiency compared with diabetic men. Resting flow was significantly higher in diabetic women compared with diabetic men, and tended to be higher in female controls as well.

Conclusions

Measures of myocardial function, metabolism, blood flow, and sympathetic activation were preserved in young, otherwise healthy, T1DM patients. However, T1DM women presented with greater myocardial oxidative metabolism requirements than men. Ongoing studies are evaluating changes over time.
Appendix
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Metadata
Title
Left ventricular metabolism, function, and sympathetic innervation in men and women with type 1 diabetes
Authors
Claire S. Duvernoy, MD
David M. Raffel, PhD
Scott D. Swanson, PhD
Mamta Jaiswal, MD
Gisela Mueller, MD
El-Sayed Ibrahim, PhD
Subramaniam Pennathur, MD
Cynthia Plunkett, RN
Jadranka Stojanovska, MD
Morton B. Brown, PhD
Rodica Pop-Busui, MD, PhD
Publication date
01-10-2016
Publisher
Springer US
Published in
Journal of Nuclear Cardiology / Issue 5/2016
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-016-0434-2

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