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Clinical Oral Investigations
Published in: Clinical Oral Investigations 6/2019

Open Access 01-06-2019 | Original Article

Left ventricular geometry and periodontitis in patients with the metabolic syndrome

Authors: Luigi Nibali, Nikos Donos, Valentina Terranova, Antonino Di Pino, Salvatore Di Marca, Viviana Ferrara, Marcella Pisano, Roberto Scicali, Agata Maria Rabuazzo, Francesco Purrello, Lorenzo Malatino

Published in: Clinical Oral Investigations | Issue 6/2019

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Abstract

Objective

The presence of periodontal disease (PD) in subjects affected by the metabolic syndrome (MetS) may affect their risk of developing cardiovascular disease. The aim of this cross-sectional study was to investigate the systemic impact of PD in MetS, by assessing measures of sub-clinical atherosclerosis and left ventricular mass and geometry.

Materials and methods

A total of 103 patients undergoing treatment for MetS were examined for confirmation of diagnosis, blood sampling, and measures of pulse wave velocity (PWV), carotid intima-media thickness (c-IMT), left ventricular mass index (LVM), and relative wall thickness (RWT). All subjects underwent a detailed dental assessment, including measurements of DMFT (decayed-missing-filled teeth) and periodontal parameters.

Results

Ten patients (10%) were diagnosed with healthy-mild periodontitis, 38 patients (37%) were diagnosed in the moderate periodontitis group, and 55 (53%) had severe periodontitis. A total of 37% of subjects were affected by dental caries. Linear regression analysis revealed that patients with severe PD had increased average ventricular RWT (adjusted p = 0.032). Average full mouth probing pocket depth (PPD) was also associated with RWT (adjusted p = 0.006). No associations between PD and c-IMT, PWV, and LVM were detected after adjusted analyses.

Conclusion

This study suggests that periodontitis may be associated with concentric left ventricular remodeling, a predictive index of cardiovascular events.

Clinical relevance

The presence of periodontitis in patients with MetS might have an effect on left ventricular geometry. These findings stress the importance of prevention, diagnosis, and management of periodontitis in patients with MetS.

Trail registration

NCT03297749
Appendix
Available only for authorised users
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Metadata
Title
Left ventricular geometry and periodontitis in patients with the metabolic syndrome
Authors
Luigi Nibali
Nikos Donos
Valentina Terranova
Antonino Di Pino
Salvatore Di Marca
Viviana Ferrara
Marcella Pisano
Roberto Scicali
Agata Maria Rabuazzo
Francesco Purrello
Lorenzo Malatino
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 6/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-018-2667-8

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