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01-11-2016 | Short Communication

Left medial orbitofrontal cortex volume correlates with skydive-elicited euphoric experience

Authors: Joshua M. Carlson, Jiook Cha, Tomer Fekete, Tsafrir Greenberg, Lilianne R. Mujica-Parodi

Published in: Brain Structure and Function | Issue 8/2016

Abstract

The medial orbitofrontal cortex has been linked to the experience of positive affect. Greater medial orbitofrontal cortex volume is associated with greater expression of positive affect and reduced medial orbital frontal cortex volume is associated with blunted positive affect. However, little is known about the experience of euphoria, or extreme joy, and how this state may relate to variability in medial orbitofrontal cortex structure. To test the hypothesis that variability in euphoric experience correlates with the volume of the medial orbitofrontal cortex, we measured individuals’ (N = 31) level of self-reported euphoria in response to a highly anticipated first time skydive and measured orbitofrontal cortical volumes with structural magnetic resonance imaging. Skydiving elicited a large increase in self-reported euphoria. Participants’ euphoric experience was predicted by the volume of their left medial orbitofrontal cortex such that, the greater the volume, the greater the euphoria. Further analyses indicated that the left medial orbitofrontal cortex and amygdalo-hippocampal complex independently explain variability in euphoric experience and that medial orbitofrontal cortex volume, in conjunction with other structures within the mOFC-centered corticolimbic circuit, can be used to predict individuals’ euphoric experience.

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Note that the volume of the amygdalo-hippocampal complex was positively correlated with prejump (left r = 0.39, P = 0.03, right r = 0.34, P = 0.05) and postjump (left r = 0.47, P = 0.01, right r = 0.39, P = 0.03) state anxiety in partial correlations controlling for age, gender, handedness, sensation seeking, scanner, and intracranial volume.

For those interested in reading more about the relationship between sensation seeking, state euphoria, state anxiety, and cortisol reactivity to skydiving we refer you to our previous work assessing these variables (Mujica-Parodi et al. 2014; Carlson et al. 2012).

In a subsample of our participants (n = 20) we collected Beck Depression scores, which were found to negatively correlate with left mOFC volume (r = −0.45, P < 0.05 in a partial correlation controlling for age, gender, handedness, and intra-cranial volume.

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Title: Left medial orbitofrontal cortex volume correlates with skydive-elicited euphoric experience
Authors: Joshua M. Carlson
Jiook Cha
Tomer Fekete
Tsafrir Greenberg
Lilianne R. Mujica-Parodi
Publication date: 01-11-2016
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 8/2016
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-015-1139-z

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Left medial orbitofrontal cortex volume correlates with skydive-elicited euphoric experience

Abstract

Keynote webinar | Spotlight on medication adherence

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