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Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2005

Open Access 01-12-2005 | Review

Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice

Authors: Wim E Crusio, Herbert Schwegler

Published in: Behavioral and Brain Functions | Issue 1/2005

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Abstract

In the present paper we review a series of experiments showing that heritable variations in the size of the hippocampal intra- and infrapyramidal mossy fiber (IIPMF) terminal fields correlate with performance in spatial, but not non-spatial radial-maze tasks. Experimental manipulation of the size of this projection by means of early postnatal hyperthyroidism produces the effects predicted from the correlations obtained with inbred mouse strains. Although the physiological mechanisms behind these correlations are unknown as yet, several lines of evidence indicate that these correlations are causal.
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Metadata
Title
Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice
Authors
Wim E Crusio
Herbert Schwegler
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2005
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/1744-9081-1-3

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