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01-01-2019 | Original Article

Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder

Authors: Katia Cristina de Oliveira, Lea Tenenholz Grinberg, Marcelo Queiroz Hoexter, Helena Brentani, Claudia Kimie Suemoto, Fabiano Gonçalves Nery, Luzia Carreira Lima, Ana Tereza Di Lorenzo Alho, José Marcelo Farfel, Renata Eloah de Lucena Ferretti-Rebustini, Renata Elaine Paraizo Leite, Ariane Cristine Moretto, Alexandre Valotta da Silva, Beny Lafer, Eurípedes Constantino Miguel, Ricardo Nitrini, Wilson Jacob-Filho, Helmut Heinsen, Carlos Augusto Pasqualucci

Published in: Brain Structure and Function | Issue 1/2019

Abstract

Neurobiological models have provided consistent evidence of the involvement of cortical–subcortical circuitry in obsessive–compulsive disorder (OCD). The orbitofrontal cortex (OFC), involved in motivation and emotional responses, is an important regulatory node within this circuitry. However, OFC abnormalities at the cellular level have so far not been studied. To address this question, we have recruited a total of seven senior individuals from the Sao Paulo Autopsy Services who were diagnosed with OCD after an extensive post-mortem clinical evaluation with their next of kin. Patients with cognitive impairment were excluded. The OCD cases were age- and sex-matched with 7 control cases and a total of 14 formalin-fixed, serially cut, and gallocyanin-stained hemispheres (7 subjects with OCD and 7 controls) were analyzed stereologically. We estimated laminar neuronal density, volume of the anteromedial (AM), medial orbitofrontal (MO), and anterolateral (AL) areas of the OFC. We found statistically significant layer- and region-specific lower neuron densities in our OCD cases that added to a deficit of 25% in AM and AL and to a deficit of 21% in MO, respectively. The volumes of the OFC areas were similar between the OCD and control groups. These results provide evidence of complex layer and region-specific neuronal deficits/loss in old OCD cases which could have a considerable impact on information processing within orbitofrontal regions and with afferent and efferent targets.

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Title: Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder
Authors: Katia Cristina de Oliveira
Lea Tenenholz Grinberg
Marcelo Queiroz Hoexter
Helena Brentani
Claudia Kimie Suemoto
Fabiano Gonçalves Nery
Luzia Carreira Lima
Ana Tereza Di Lorenzo Alho
José Marcelo Farfel
Renata Eloah de Lucena Ferretti-Rebustini
Renata Elaine Paraizo Leite
Ariane Cristine Moretto
Alexandre Valotta da Silva
Beny Lafer
Eurípedes Constantino Miguel
Ricardo Nitrini
Wilson Jacob-Filho
Helmut Heinsen
Carlos Augusto Pasqualucci
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2019
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-018-1752-8

At a glance: The STEP trials

Springer Medicine

Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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