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Reproductive Biology and Endocrinology

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Open Access 01-12-2015 | Research

Late follicular progesterone to estradiol ratio is not influenced by protocols or gonadotropins used

Authors: E. Shalom-Paz, N. Aslih, N. Samara, M. Michaeli, A. Ellenbogen

Published in: Reproductive Biology and Endocrinology | Issue 1/2015

Abstract

Objective

Increased progesterone level during follicular phase seemed to be associated with decreased pregnancy rate.

Study design and methods

A prospective cohort study, 1.1.2012 - 31.8.13. The Progesterone (P) and Progesterone/Estrogen (P/E2) level on ovulation induction day were compared between the protocols and the different gonadotropins used. Roc analysis was calculated to determine the cutoff of P/E2 to predict delivery rates. P/E2 ratio was calculated as PX1000/e2 level.

Main results

One hundred thirty-nine patients were enrolled to the study. No difference in the P level at hCG stimulation day between different protocols, however, E2 and P/E2 ratio were significantly lower in the long protocol compare with antagonist protocol 1757.7 ± 923.2 vs. 1342.9 ± 1223; P = 0.003 and 0.48 ± 0.31 vs. 0.83 ± 0.87; P = 0.038). The endometrium was significantly thicker in the long group compare with short and antagonist. Significantly more top-quality embryos (TOP) were achieved in the antagonist group. Comparable results between the types of gonadotropins used in regards with cycle characteristics and pregnancy and delivery rates. The P/E2 ratio which can predict live birth rate was found to be 0.45, AUC = 0.632, p = 0.02 and 95 % CI 0.525–0.738 and a significantly higher pregnancy and delivery rates at a P/E2 bellow 0.45.

Conclusion

Endometrial receptivity is determined by the complex interactions of E2 and P.

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Title: Late follicular progesterone to estradiol ratio is not influenced by protocols or gonadotropins used
Authors: E. Shalom-Paz
N. Aslih
N. Samara
M. Michaeli
A. Ellenbogen
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2015
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/s12958-015-0116-y

At a glance: The STEP trials

Springer Medicine

Late follicular progesterone to estradiol ratio is not influenced by protocols or gonadotropins used

Abstract

Objective

Study design and methods

Main results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Study design and methods

Main results

Conclusion

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