Skip to main content
Top
Published in: World Journal of Urology 1/2024

Open Access 01-12-2024 | Laser | Original Article

Cost-effectiveness of quality improvement intervention to reduce time between CT-detection and ureteroscopic laser fragmentation in acute symptomatic ureteric stones management

Authors: Faid Khopekar, Soha Nabi, Mehdi Shiva, Morven Stewart, Benedict Rajendran, Ghulam Nabi

Published in: World Journal of Urology | Issue 1/2024

Login to get access

Abstract

Objective

To prospectively assess clinical and cost effectiveness of emergency ureteroscopic laser fragmentation of urinary stones causing symptoms or obstruction.

Patients and methods

100 consecutive patients with an average (median) age 55.6 (57.5) years and average (median) stone size of 8.2 mm (± 7 mm) between October 2018 and December 2021 who underwent emergency ureteroscopy and laser fragmentation formed the study cohort as part of a clinical service quality improvement. Primary outcome was single procedure stone-free rate and cost-effectiveness. The secondary outcomes were complications, re-admission and re-intervention. A decision analysis model was constructed to compare the cost-effectiveness of emergency ureteroscopy with laser fragmentation (EUL) and emergency temporary stenting followed by delayed ureteroscopy with laser fragmentation (DUL) using our results and success rates for modelling.

Results

Single procedure stone-free rates (SFR) for EUL and DUL were 85%. The re-intervention rate, re-admission and complication rates of the study cohort (EUL) were 9%, 18%, and 4%, respectively, compared to 15%, 20%, and 5%, respectively for the control cohort (DUL). The decision analysis modelling demonstrated that the EUL treatment option was more cost-efficient, averting £2868 (€3260) per patient for the UK health sector. Total cost of delayed intervention was £7783 (€8847) for DUL in contrast to £4915 (€5580) for EUL.

Conclusions

Implementation of quality improvement project based on a reduction in CT detection-to-laser fragmentation time interval in acute ureteric obstruction or symptoms caused by stones had similar clinical effectiveness compared to delayed ureteroscopic management, but more cost-effective.
Appendix
Available only for authorised users
Literature
1.
go back to reference Raheem OA, Khandwala YS, Sur RL, Ghani KR, Denstedt JD (2017) Burden of urolithiasis: trends in prevalence, treatments, and costs. Eur Urol Focus 3(1):18–26CrossRefPubMed Raheem OA, Khandwala YS, Sur RL, Ghani KR, Denstedt JD (2017) Burden of urolithiasis: trends in prevalence, treatments, and costs. Eur Urol Focus 3(1):18–26CrossRefPubMed
2.
go back to reference Rukin NJ, Siddiqui ZA, Chedgy ECP, Somani BK (2017) Trends in upper tract stone disease in England: evidence from the hospital episodes statistics database. Urol Int 98(4):391–396CrossRefPubMed Rukin NJ, Siddiqui ZA, Chedgy ECP, Somani BK (2017) Trends in upper tract stone disease in England: evidence from the hospital episodes statistics database. Urol Int 98(4):391–396CrossRefPubMed
4.
go back to reference NICE. Renal and ureteric stones: assessment and management | 2019 [cited 2022. NICE. Renal and ureteric stones: assessment and management | 2019 [cited 2022.
5.
go back to reference Osorio L, Lima E, Soares J, Autorino R, Versos R, Lhamas A et al (2007) Emergency ureteroscopic management of ureteral stones: why not? Urology 69(1):27–31 (discussion -3)CrossRefPubMed Osorio L, Lima E, Soares J, Autorino R, Versos R, Lhamas A et al (2007) Emergency ureteroscopic management of ureteral stones: why not? Urology 69(1):27–31 (discussion -3)CrossRefPubMed
6.
go back to reference Guercio S, Ambu A, Mangione F, Mari M, Vacca F, Bellina M (2011) Randomized prospective trial comparing immediate versus delayed ureteroscopy for patients with ureteral calculi and normal renal function who present to the emergency department. J Endourol 25(7):1137–1141CrossRefPubMed Guercio S, Ambu A, Mangione F, Mari M, Vacca F, Bellina M (2011) Randomized prospective trial comparing immediate versus delayed ureteroscopy for patients with ureteral calculi and normal renal function who present to the emergency department. J Endourol 25(7):1137–1141CrossRefPubMed
7.
go back to reference Arcaniolo D, De Sio M, Rassweiler J, Nicholas J, Lima E, Carrieri G et al (2017) Emergent versus delayed lithotripsy for obstructing ureteral stones: a cumulative analysis of comparative studies. Urolithiasis 45(6):563–572CrossRefPubMed Arcaniolo D, De Sio M, Rassweiler J, Nicholas J, Lima E, Carrieri G et al (2017) Emergent versus delayed lithotripsy for obstructing ureteral stones: a cumulative analysis of comparative studies. Urolithiasis 45(6):563–572CrossRefPubMed
8.
go back to reference Al-Terki A, Alkabbani M, Alenezi TA, Al-Shaiji TF, Al-Mousawi S, El-Nahas AR (2020) Emergency vs elective ureteroscopy for a single ureteric stone. Arab J Urol 19(2):137–140CrossRefPubMedPubMedCentral Al-Terki A, Alkabbani M, Alenezi TA, Al-Shaiji TF, Al-Mousawi S, El-Nahas AR (2020) Emergency vs elective ureteroscopy for a single ureteric stone. Arab J Urol 19(2):137–140CrossRefPubMedPubMedCentral
9.
go back to reference Scales CD Jr, Lin L, Saigal CS, Bennett CJ, Ponce NA, Mangione CM et al (2015) Emergency department revisits for patients with kidney stones in California. Acad Emerg Med 22(4):468–474CrossRefPubMedPubMedCentral Scales CD Jr, Lin L, Saigal CS, Bennett CJ, Ponce NA, Mangione CM et al (2015) Emergency department revisits for patients with kidney stones in California. Acad Emerg Med 22(4):468–474CrossRefPubMedPubMedCentral
11.
go back to reference Kim CS, Spahlinger DA, Kin JM, Billi JE (2006) Lean health care: what can hospitals learn from a world-class automaker? J Hosp Med 1(3):191–199CrossRefPubMed Kim CS, Spahlinger DA, Kin JM, Billi JE (2006) Lean health care: what can hospitals learn from a world-class automaker? J Hosp Med 1(3):191–199CrossRefPubMed
12.
go back to reference Ajmi SC, Kurz MW, Ersdal H, Lindner T, Goyal M, Issenberg SB et al (2022) Cost-effectiveness of a quality improvement project, including simulation-based training, on reducing door-to-needle times in stroke thrombolysis. BMJ Qual Saf 31(8):569–578CrossRefPubMed Ajmi SC, Kurz MW, Ersdal H, Lindner T, Goyal M, Issenberg SB et al (2022) Cost-effectiveness of a quality improvement project, including simulation-based training, on reducing door-to-needle times in stroke thrombolysis. BMJ Qual Saf 31(8):569–578CrossRefPubMed
15.
go back to reference Park J, Choi KH, Lee JM, Kim HK, Hwang D, Rhee TM et al (2019) Prognostic implications of door-to-balloon time and onset-to-door time on mortality in patients with ST-segment-elevation myocardial infarction treated with primary percutaneous coronary intervention. J Am Heart Assoc 8(9):e012188CrossRefPubMedPubMedCentral Park J, Choi KH, Lee JM, Kim HK, Hwang D, Rhee TM et al (2019) Prognostic implications of door-to-balloon time and onset-to-door time on mortality in patients with ST-segment-elevation myocardial infarction treated with primary percutaneous coronary intervention. J Am Heart Assoc 8(9):e012188CrossRefPubMedPubMedCentral
16.
go back to reference Fonarow GC, Zhao X, Smith EE, Saver JL, Reeves MJ, Bhatt DL et al (2014) Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative. JAMA 311(16):1632–1640CrossRefPubMed Fonarow GC, Zhao X, Smith EE, Saver JL, Reeves MJ, Bhatt DL et al (2014) Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative. JAMA 311(16):1632–1640CrossRefPubMed
18.
go back to reference Patel N, Brown RD, Sarkissian C, De S, Monga M (2017) Quality of life and urolithiasis: the patient—reported outcomes measurement information system (PROMIS). Int Braz J Urol 43(5):880–886CrossRefPubMedPubMedCentral Patel N, Brown RD, Sarkissian C, De S, Monga M (2017) Quality of life and urolithiasis: the patient—reported outcomes measurement information system (PROMIS). Int Braz J Urol 43(5):880–886CrossRefPubMedPubMedCentral
21.
go back to reference Bate P, Robert G (2006) Experience-based design: from redesigning the system around the patient to co-designing services with the patient. Qual Saf Health Care 15(5):307–310CrossRefPubMedPubMedCentral Bate P, Robert G (2006) Experience-based design: from redesigning the system around the patient to co-designing services with the patient. Qual Saf Health Care 15(5):307–310CrossRefPubMedPubMedCentral
22.
go back to reference Kartha G, Calle JC, Marchini GS, Monga M (2013) Impact of stone disease: chronic kidney disease and quality of life. Urol Clin North Am 40(1):135–147CrossRefPubMed Kartha G, Calle JC, Marchini GS, Monga M (2013) Impact of stone disease: chronic kidney disease and quality of life. Urol Clin North Am 40(1):135–147CrossRefPubMed
24.
go back to reference Paterson C, Yew-Fung C, Sweeney C, Szewczyk-Bieda M, Lang S, Nabi G (2017) Predictors of growth kinetics and outcomes in small renal masses (SRM </=4 cm in size): Tayside Active Surveillance Cohort (TASC) Study. Eur J Surg Oncol 43(8):1589–1597CrossRefPubMed Paterson C, Yew-Fung C, Sweeney C, Szewczyk-Bieda M, Lang S, Nabi G (2017) Predictors of growth kinetics and outcomes in small renal masses (SRM </=4 cm in size): Tayside Active Surveillance Cohort (TASC) Study. Eur J Surg Oncol 43(8):1589–1597CrossRefPubMed
25.
go back to reference Flynn RW, MacDonald TM, Murray GD, Ferguson C, Shah K, Doney AS (2010) The Tayside Stroke Cohort: exploiting advanced regional medical informatics to create a region-wide database for studying the pharmacoepidemiology of stroke. Pharmacoepidemiol Drug Saf 19(7):737–744CrossRefPubMed Flynn RW, MacDonald TM, Murray GD, Ferguson C, Shah K, Doney AS (2010) The Tayside Stroke Cohort: exploiting advanced regional medical informatics to create a region-wide database for studying the pharmacoepidemiology of stroke. Pharmacoepidemiol Drug Saf 19(7):737–744CrossRefPubMed
27.
go back to reference Kijvikai K, Haleblian GE, Preminger GM, de la Rosette J (2007) Shock wave lithotripsy or ureteroscopy for the management of proximal ureteral calculi: an old discussion revisited. J Urol 178(4 Pt 1):1157–1163CrossRefPubMed Kijvikai K, Haleblian GE, Preminger GM, de la Rosette J (2007) Shock wave lithotripsy or ureteroscopy for the management of proximal ureteral calculi: an old discussion revisited. J Urol 178(4 Pt 1):1157–1163CrossRefPubMed
29.
go back to reference Youn JH, Kim SS, Yu JH, Sung LH, Noh CH, Chung JY (2012) Efficacy and safety of emergency ureteroscopic management of ureteral calculi. Korean J Urol 53(9):632–635CrossRefPubMedPubMedCentral Youn JH, Kim SS, Yu JH, Sung LH, Noh CH, Chung JY (2012) Efficacy and safety of emergency ureteroscopic management of ureteral calculi. Korean J Urol 53(9):632–635CrossRefPubMedPubMedCentral
30.
go back to reference Wani M, Burki J, Melhem M, Gilani S, Ghumman F, Masood S (2021) Is primary ureteroscopy an alternative to emergency stenting in terms of quality and cost? Cent Eur J Urol 74(3):446–450 Wani M, Burki J, Melhem M, Gilani S, Ghumman F, Masood S (2021) Is primary ureteroscopy an alternative to emergency stenting in terms of quality and cost? Cent Eur J Urol 74(3):446–450
31.
go back to reference Castelli C, Combescure C, Foucher Y, Daures JP (2007) Cost-effectiveness analysis in colorectal cancer using a semi-Markov model. Stat Med 26(30):5557–5571MathSciNetCrossRefPubMed Castelli C, Combescure C, Foucher Y, Daures JP (2007) Cost-effectiveness analysis in colorectal cancer using a semi-Markov model. Stat Med 26(30):5557–5571MathSciNetCrossRefPubMed
32.
go back to reference Sonnenberg FA, Beck JR (1993) Markov models in medical decision making: a practical guide. Med Decis Making 13(4):322–338CrossRefPubMed Sonnenberg FA, Beck JR (1993) Markov models in medical decision making: a practical guide. Med Decis Making 13(4):322–338CrossRefPubMed
33.
go back to reference Wilhelm K, Hahn O, Schoenthaler M, Hein S, Neubauer J, Schnabel M, Neisius A (2019) Stone-free rate after treating kidney stones exceeding 10 mm via flexible ureteroscopy: can endoscopic assessment replace low-dose computed tomography control? Urol Int 103(3):326–330CrossRefPubMed Wilhelm K, Hahn O, Schoenthaler M, Hein S, Neubauer J, Schnabel M, Neisius A (2019) Stone-free rate after treating kidney stones exceeding 10 mm via flexible ureteroscopy: can endoscopic assessment replace low-dose computed tomography control? Urol Int 103(3):326–330CrossRefPubMed
Metadata
Title
Cost-effectiveness of quality improvement intervention to reduce time between CT-detection and ureteroscopic laser fragmentation in acute symptomatic ureteric stones management
Authors
Faid Khopekar
Soha Nabi
Mehdi Shiva
Morven Stewart
Benedict Rajendran
Ghulam Nabi
Publication date
01-12-2024
Publisher
Springer Berlin Heidelberg
Keyword
Laser
Published in
World Journal of Urology / Issue 1/2024
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-023-04694-4

Other articles of this Issue 1/2024

World Journal of Urology 1/2024 Go to the issue