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01-04-2022 | Laparotomy | Original Article

Liquid resorbable nanofibrous surgical mesh: a proof of a concept

Authors: B. East, J. Woleský, R. Divín, M. Otáhal, K. Vocetková, V. Sovková, V. H. Blahnová, M. Koblížek, P. Kubový, A. Nečasová, A. Staffa, A. Ch. de Beaux, J. Lorenzová, E. Amler

Published in: Hernia | Issue 2/2022

Abstract

Background

Surgical mesh is widely used not only to treat but also to prevent incisional hernia formation. Despite much effort by material engineers, the 'ideal' mesh mechanically, biologically and surgically easy to use remains elusive. Advances in tissue engineering and nanomedicine have allowed new concepts to be tested with promising results in both small and large animals. Abandoning the concept of a pre-formed mesh completely for a ‘pour in liquid mesh’ has never been tested before.

Materials and methods

Thirty rabbits underwent midline laparotomy with closure using an absorbable suture and small stitch small bites technique. In addition, their abdominal wall closure was reinforced by a liquid nanofibrous scaffold composed of a fibrin sealant and nanofibres of poly-ε-caprolactone with or without hyaluronic acid or the sealant alone, poured in as an ‘onlay’ over the closed abdominal wall. The animals were killed at 6 weeks and their abdominal wall was subjected to histological and biomechanical evaluations.

Results

All the animals survived the study period with no major complication. Histological evaluation showed an eosinophilic infiltration in all groups and foreign body reaction more pronounced in the groups with nanofibres. Biomechanical testing demonstrated that groups treated with nanofibres developed a scar with higher tensile yield strength.

Conclusion

The use of nanofibres in a liquid form applied to the closed abdominal wall is easy to use and improves the biomechanical properties of healing fascia at 6 weeks after midline laparotomy in a rabbit model.

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Title: Liquid resorbable nanofibrous surgical mesh: a proof of a concept
Authors: B. East
J. Woleský
R. Divín
M. Otáhal
K. Vocetková
V. Sovková
V. H. Blahnová
M. Koblížek
P. Kubový
A. Nečasová
A. Staffa
A. Ch. de Beaux
J. Lorenzová
E. Amler
Publication date: 01-04-2022
Publisher: Springer Paris
Keywords: Laparotomy
Laparotomy
Incisional Hernia
Published in: Hernia / Issue 2/2022
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI: https://doi.org/10.1007/s10029-022-02582-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Liquid resorbable nanofibrous surgical mesh: a proof of a concept

Abstract

Background

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Materials and methods

Results

Conclusion

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