Skip to main content
Top
Published in: Obesity Surgery 2/2018

01-02-2018 | Original Contributions

Laparoscopic Nissen Fundoplication Plus Mid-gastric Plication for Treatment of Obese Patients with Gastroesophageal Reflux Disease

Authors: Ahmed Talha, Mohammed Ibrahim

Published in: Obesity Surgery | Issue 2/2018

Login to get access

Abstract

Background

Gastroesophageal reflux disease (GERD) is commonly associated with obesity, and its surgical management is debatable.

Objective

The objective of this study was to prove the safety and feasibility of laparoscopic Nissen’s fundoplication (LNF) combined with mid-gastric plication (MGP) for treatment of obese patients with GERD.

Methods

LNF combined with MGP was done for 18 patients. All interventions were performed under general anesthesia. The follow-up protocol included body mass index (BMI), percentage of excess weight loss (%EWL), percentage of excess BMI loss (%EBMIL), and clinical assessment using the Gastro-esophageal Reflux Health-Related Quality-of-Life (GERD-HRQOL) scale at 6 and 12 months.

Results

The period of follow-up ranged from 12 to 33 months with a mean of 17.74 ± 3.73 months. The operation time was 1.40 ± 0.27 h. No serious procedure-related complications occurred. GERD-related symptoms resolved in all patients (p < 0.001). There was a significant improvment in endoscopic findings at 6 months compared to properatively (p = 0.001). There was a significant patient satisfaction score using GERD-HRQOL at 6 and 12 months (p = 0.000). The 1-year follow-up excess weight was significantly less than the baseline excess weight (p < 0.001). The average BMI decreased from 37.59 ± 1.89 kg/m2 at baseline to 30.61 ± 1.57 kg/m2 at 1 year (p < 0.001).

Conclusions

LNF combined with MGP for treatment of obese patients with GERD is technically safe, feasible, and promising with no serious procedure-related complications. The technique is effective in terms of weight loss and cure of GERD. However, future larger studies are required to demonstrate the safety, effectiveness, and long-term durability of the procedure.
Literature
1.
go back to reference Oh DS, DeMeester SR, Vallbohmer D, et al. Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett’s esophagus with antireflux surgery. Arch Surg. 2007;142:554–60.CrossRefPubMed Oh DS, DeMeester SR, Vallbohmer D, et al. Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett’s esophagus with antireflux surgery. Arch Surg. 2007;142:554–60.CrossRefPubMed
2.
go back to reference Bu X, Ma Y, Der R, et al. Body mass index is associated with Barrett’s esophagus and cardiac mucosal metaplasia. Dig Dis Sci. 2006;51:1589–94.CrossRefPubMed Bu X, Ma Y, Der R, et al. Body mass index is associated with Barrett’s esophagus and cardiac mucosal metaplasia. Dig Dis Sci. 2006;51:1589–94.CrossRefPubMed
3.
go back to reference Santonicola A, Angrisani L, Cutolo P, et al. The effect of laparoscopic sleeve gastrectomy with or without hiatal hernia repair on gastroesophageal reflux disease in obese patients. Surg Obes Relat Dis. 2014;10(2):250–5.CrossRefPubMed Santonicola A, Angrisani L, Cutolo P, et al. The effect of laparoscopic sleeve gastrectomy with or without hiatal hernia repair on gastroesophageal reflux disease in obese patients. Surg Obes Relat Dis. 2014;10(2):250–5.CrossRefPubMed
4.
go back to reference Merrouche M, Sabaté JM, Jouet P, et al. Gastroesophageal reflux and esophageal motility disorders in morbidly obese patients before and after bariatric surgery. Obes Surg. 2007;17:894–900.CrossRefPubMed Merrouche M, Sabaté JM, Jouet P, et al. Gastroesophageal reflux and esophageal motility disorders in morbidly obese patients before and after bariatric surgery. Obes Surg. 2007;17:894–900.CrossRefPubMed
5.
go back to reference Korenkov M, Köhler L, Yücel N, et al. Esophageal motility and reflux symptoms before and after bariatric surgery. Obes Surg. 2002;12:72–6.CrossRefPubMed Korenkov M, Köhler L, Yücel N, et al. Esophageal motility and reflux symptoms before and after bariatric surgery. Obes Surg. 2002;12:72–6.CrossRefPubMed
6.
go back to reference Rebecchi F, Rocchietto S, Giaccone C, et al. Gastroesophageal reflux disease and esophageal motility in morbidly obese patients submitted to laparoscopic adjustable silicone gastric banding or laparoscopic vertical banded gastroplasty. Surg Endosc. 2011;25(3):795–803.CrossRefPubMed Rebecchi F, Rocchietto S, Giaccone C, et al. Gastroesophageal reflux disease and esophageal motility in morbidly obese patients submitted to laparoscopic adjustable silicone gastric banding or laparoscopic vertical banded gastroplasty. Surg Endosc. 2011;25(3):795–803.CrossRefPubMed
7.
go back to reference Patti MG. An evidence-based approach to the treatment of gastroesophageal reflux disease. JAMA Surg. 2016;151(1):73–8.CrossRefPubMed Patti MG. An evidence-based approach to the treatment of gastroesophageal reflux disease. JAMA Surg. 2016;151(1):73–8.CrossRefPubMed
8.
go back to reference Varela JE, Hinojosa MW, Nguyen NT. Laparoscopic fundoplication compared with laparoscopic gastric bypass in morbidly obese patients with gastroesophageal reflux disease. Surg Obes Relat Dis. 2009;5:139–43.CrossRefPubMed Varela JE, Hinojosa MW, Nguyen NT. Laparoscopic fundoplication compared with laparoscopic gastric bypass in morbidly obese patients with gastroesophageal reflux disease. Surg Obes Relat Dis. 2009;5:139–43.CrossRefPubMed
9.
go back to reference Talebpour M, Amoli BS. Laparoscopic total gastric vertical plication in morbid obesity. J Laparoend Adv Surg Tech. 2007;17(6):793–8.CrossRef Talebpour M, Amoli BS. Laparoscopic total gastric vertical plication in morbid obesity. J Laparoend Adv Surg Tech. 2007;17(6):793–8.CrossRef
10.
go back to reference Kourkoulos M, Giorgakis E, Kokkinos C, et al. Laparoscopic gastric plication for the treatment of morbid obesity: a review. Hindawi Publishing Corporation. Minim Invasive Surg, Article ID. 2012:696348, 7 pages. doi:10.1155/2012/696348. Kourkoulos M, Giorgakis E, Kokkinos C, et al. Laparoscopic gastric plication for the treatment of morbid obesity: a review. Hindawi Publishing Corporation. Minim Invasive Surg, Article ID. 2012:696348, 7 pages. doi:10.​1155/​2012/​696348.
11.
go back to reference Rickenbacher N, Kötter T, Kochen MM, et al. Fundoplication versus medical management of gastroesophageal reflux disease: systematic review and meta-analysis. Surg Endosc. 2014;28(1):143–55.CrossRefPubMed Rickenbacher N, Kötter T, Kochen MM, et al. Fundoplication versus medical management of gastroesophageal reflux disease: systematic review and meta-analysis. Surg Endosc. 2014;28(1):143–55.CrossRefPubMed
12.
go back to reference Velanovich V, Vallance SR, Gusz JR, et al. Quality-of-life scale for gastroesophageal reflux disease. J Am Coll Surg. 1996;183:217–24.PubMed Velanovich V, Vallance SR, Gusz JR, et al. Quality-of-life scale for gastroesophageal reflux disease. J Am Coll Surg. 1996;183:217–24.PubMed
13.
go back to reference Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of esophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45:172–80.CrossRefPubMedPubMedCentral Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of esophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45:172–80.CrossRefPubMedPubMedCentral
14.
go back to reference Gianos M, Abdemur A, Fendrich I, et al. Outcomes of bariatric surgery in patients with body mass index <35 kg/m2. Surg Obes Relat Dis. 2012;8(1):25–30.CrossRefPubMed Gianos M, Abdemur A, Fendrich I, et al. Outcomes of bariatric surgery in patients with body mass index <35 kg/m2. Surg Obes Relat Dis. 2012;8(1):25–30.CrossRefPubMed
15.
go back to reference ASMBS statements/guidelines. Bariatric surgery in class I obesity (body mass index 30–35 kg/m2) ASMBS Clinical Issues Committee. Surg Obes Related Dis. 2013;9:e1–e10.CrossRef ASMBS statements/guidelines. Bariatric surgery in class I obesity (body mass index 30–35 kg/m2) ASMBS Clinical Issues Committee. Surg Obes Related Dis. 2013;9:e1–e10.CrossRef
16.
go back to reference Noun R, Chakhtoura G, Nasr M, Skaff J, Choucair N, Rkaybi N, Tohme-Noun C. Laparoscopic sleeve gastrectomy for mildly obese patients (body mass index of 30 <35 kg/m2): operative outcome and short-term results. J Obes 2012, Article ID 813650, 5 pages doi:10.1155/2012/813650. Noun R, Chakhtoura G, Nasr M, Skaff J, Choucair N, Rkaybi N, Tohme-Noun C. Laparoscopic sleeve gastrectomy for mildly obese patients (body mass index of 30 <35 kg/m2): operative outcome and short-term results. J Obes 2012, Article ID 813650, 5 pages doi:10.​1155/​2012/​813650.
17.
18.
go back to reference Khazzaka A, Sarkis R. Fundoplication combined with mediogastric plication. Surg Obes Relat Dis. 2013;9:398–404.CrossRefPubMed Khazzaka A, Sarkis R. Fundoplication combined with mediogastric plication. Surg Obes Relat Dis. 2013;9:398–404.CrossRefPubMed
19.
go back to reference Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005;143:199–211.CrossRefPubMed Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005;143:199–211.CrossRefPubMed
21.
go back to reference Lee WJ, Han ML, Ser KH, et al. Laparoscopic Nissen fundoplication with gastric plication as a potential treatment of morbidly obese patients with GERD, first experience and results. Obes Surg. 2014;24(9):1447–52.CrossRefPubMed Lee WJ, Han ML, Ser KH, et al. Laparoscopic Nissen fundoplication with gastric plication as a potential treatment of morbidly obese patients with GERD, first experience and results. Obes Surg. 2014;24(9):1447–52.CrossRefPubMed
22.
go back to reference Lomanto D, Lee WJ, Goel R, et al. Bariatric surgery in Asia in the last 5 years (2005 – 2009). Obes Surg. 2012;22:502–6.CrossRefPubMed Lomanto D, Lee WJ, Goel R, et al. Bariatric surgery in Asia in the last 5 years (2005 – 2009). Obes Surg. 2012;22:502–6.CrossRefPubMed
24.
go back to reference Naik RD, Choksi YA, Vaezi MF. Impact of weight loss surgery on esophageal physiology. Gastroenterol Hepatol. 2015;11(12):801–9. Naik RD, Choksi YA, Vaezi MF. Impact of weight loss surgery on esophageal physiology. Gastroenterol Hepatol. 2015;11(12):801–9.
25.
26.
go back to reference Soricelli E, Iossa A, Casella G, et al. Sleeve gastrectomy and crural repair in obese patients with gastroesophageal reflux disease and/or hiatal hernia. Surg Obes Relat Dis. 2013;9:356–61.CrossRefPubMed Soricelli E, Iossa A, Casella G, et al. Sleeve gastrectomy and crural repair in obese patients with gastroesophageal reflux disease and/or hiatal hernia. Surg Obes Relat Dis. 2013;9:356–61.CrossRefPubMed
27.
go back to reference DuPree CE, Blair K, Steele SR, et al. Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux disease: a national analysis. JAMA Surg. 2014;149:328–34.CrossRefPubMed DuPree CE, Blair K, Steele SR, et al. Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux disease: a national analysis. JAMA Surg. 2014;149:328–34.CrossRefPubMed
28.
go back to reference Sharma A, Aggarwal S, Ahuja V, et al. Evaluation of gastroesophageal reflux before and after sleeve gastrectomy using symptom scoring, scintigraphy, and endoscopy. Surg Obes Relat Dis. 2014;10:600–5.CrossRefPubMed Sharma A, Aggarwal S, Ahuja V, et al. Evaluation of gastroesophageal reflux before and after sleeve gastrectomy using symptom scoring, scintigraphy, and endoscopy. Surg Obes Relat Dis. 2014;10:600–5.CrossRefPubMed
29.
go back to reference Rebecchi F, Allaix ME, Giaccone C, et al. Gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a physiopathologic evaluation. Ann Surg. 2014;260:909–14. discussion 914–5CrossRefPubMed Rebecchi F, Allaix ME, Giaccone C, et al. Gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a physiopathologic evaluation. Ann Surg. 2014;260:909–14. discussion 914–5CrossRefPubMed
30.
go back to reference Daes J, Jimenez ME, Said N, et al. Improvement of gastroesophageal reflux symptoms after standardized laparoscopic sleeve gastrectomy. Obes Surg. 2014;24:536–40.CrossRefPubMed Daes J, Jimenez ME, Said N, et al. Improvement of gastroesophageal reflux symptoms after standardized laparoscopic sleeve gastrectomy. Obes Surg. 2014;24:536–40.CrossRefPubMed
31.
go back to reference Pallati PK, Shaligram A, Shostrom VK, et al. Improvement in gastroesophageal reflux disease symptoms after various bariatric procedures: review of the Bariatric Outcomes Longitudinal Database. Surg Obes Relat Dis. 2014;10:502–7.CrossRefPubMed Pallati PK, Shaligram A, Shostrom VK, et al. Improvement in gastroesophageal reflux disease symptoms after various bariatric procedures: review of the Bariatric Outcomes Longitudinal Database. Surg Obes Relat Dis. 2014;10:502–7.CrossRefPubMed
32.
go back to reference Braghetto I, Korn O, Csendes A, et al. Laparoscopic treatment of obese patients with gastroesophageal reflux disease and Barrett’s esophagus: a prospective study. Obes Surg. 2012;22:764–72.CrossRefPubMed Braghetto I, Korn O, Csendes A, et al. Laparoscopic treatment of obese patients with gastroesophageal reflux disease and Barrett’s esophagus: a prospective study. Obes Surg. 2012;22:764–72.CrossRefPubMed
33.
go back to reference EL-Hayek K, Timratana P, Shimizu H, et al. Marginal ulcer after Roux-en-Y gastric bypass: what we really learned? Surg Endosc. 2012;26(10):2789–96.CrossRefPubMed EL-Hayek K, Timratana P, Shimizu H, et al. Marginal ulcer after Roux-en-Y gastric bypass: what we really learned? Surg Endosc. 2012;26(10):2789–96.CrossRefPubMed
34.
go back to reference Paroz A, Calmes JM, Giusti V. Internal hernia after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a continuous challenge in bariatric surgery. Obes Surg. 2006;16:1482–7.CrossRefPubMed Paroz A, Calmes JM, Giusti V. Internal hernia after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a continuous challenge in bariatric surgery. Obes Surg. 2006;16:1482–7.CrossRefPubMed
35.
go back to reference Gasteyger C, Suter M, Gaillard RC, et al. Nutritional deficiencies after Roux-en-Y gastric bypass for morbid obesity often cannot be prevented by standard multivitamin supplementation. Am J Clin Nutr. 2008;87:1128–33.PubMed Gasteyger C, Suter M, Gaillard RC, et al. Nutritional deficiencies after Roux-en-Y gastric bypass for morbid obesity often cannot be prevented by standard multivitamin supplementation. Am J Clin Nutr. 2008;87:1128–33.PubMed
36.
go back to reference Lee WJ, Ser KH, Lee YC, et al. Laparoscopic Roux-en-Y vs. mini- gastric bypass for the treatment of morbid obesity: a 10-year experience. Obes Surg. 2012;22:1827–34.CrossRefPubMed Lee WJ, Ser KH, Lee YC, et al. Laparoscopic Roux-en-Y vs. mini- gastric bypass for the treatment of morbid obesity: a 10-year experience. Obes Surg. 2012;22:1827–34.CrossRefPubMed
37.
go back to reference Gutschow CA, Collet P, Prenzel K, et al. Long-term results and gastroesophageal reflux in a series of laparoscopic adjustable gastric banding. J Gastrointest Surg. 2005;9(7):941–8.CrossRefPubMed Gutschow CA, Collet P, Prenzel K, et al. Long-term results and gastroesophageal reflux in a series of laparoscopic adjustable gastric banding. J Gastrointest Surg. 2005;9(7):941–8.CrossRefPubMed
38.
go back to reference Wilkinson LH, Peloso OA. Gastric (reservoir) reduction for morbid obesity. Arch Surg. 1981;116:602–5.CrossRefPubMed Wilkinson LH, Peloso OA. Gastric (reservoir) reduction for morbid obesity. Arch Surg. 1981;116:602–5.CrossRefPubMed
39.
go back to reference Niazi M, Maleki AR, Talebpour M. Short-term outcomes of laparoscopic gastric plication in morbidly obese patients: importance of postoperative follow-up. Obes Surg. 2013;23:87–92.CrossRefPubMed Niazi M, Maleki AR, Talebpour M. Short-term outcomes of laparoscopic gastric plication in morbidly obese patients: importance of postoperative follow-up. Obes Surg. 2013;23:87–92.CrossRefPubMed
40.
go back to reference Skrekas G, Antiochos K, Stafyla VK. Laparoscopic gastric greater curvature plication: results and complications in a series of 135 patients. Obes Surg. 2011;21:1657–63.CrossRefPubMed Skrekas G, Antiochos K, Stafyla VK. Laparoscopic gastric greater curvature plication: results and complications in a series of 135 patients. Obes Surg. 2011;21:1657–63.CrossRefPubMed
41.
go back to reference Huang CK, Asim S, Lo CH. Augmenting weight loss after laparoscopic adjustable gastric banding by laparoscopic gastric plication. Surg Obes Relat Dis. 2011;7:235–6.CrossRefPubMed Huang CK, Asim S, Lo CH. Augmenting weight loss after laparoscopic adjustable gastric banding by laparoscopic gastric plication. Surg Obes Relat Dis. 2011;7:235–6.CrossRefPubMed
42.
go back to reference Huang CK, Lo CH, Shabbir A, et al. Novel bariatric technology: laparoscopic adjustable gastric banded plication: technique and preliminary results. Surg Obes Relat Dis. 2012;8:41–7.CrossRefPubMed Huang CK, Lo CH, Shabbir A, et al. Novel bariatric technology: laparoscopic adjustable gastric banded plication: technique and preliminary results. Surg Obes Relat Dis. 2012;8:41–7.CrossRefPubMed
43.
go back to reference De Prisco C, Levine SN. Metabolic bone disease after gastric bypass surgery for obesity. Am J Med Sci. 2005;329:57–61.CrossRefPubMed De Prisco C, Levine SN. Metabolic bone disease after gastric bypass surgery for obesity. Am J Med Sci. 2005;329:57–61.CrossRefPubMed
44.
go back to reference Fujioka K. Follow-up of nutritional and metabolic problems after bariatric surgery. Diabetes Care. 2005;28:481–4.CrossRefPubMed Fujioka K. Follow-up of nutritional and metabolic problems after bariatric surgery. Diabetes Care. 2005;28:481–4.CrossRefPubMed
45.
go back to reference Brethauer SA, Harris JL, Kroh M, et al. Laparoscopic gastric plication for treatment of severe obesity. Surg Obes Relat Dis. 2011;7:15–22.CrossRefPubMed Brethauer SA, Harris JL, Kroh M, et al. Laparoscopic gastric plication for treatment of severe obesity. Surg Obes Relat Dis. 2011;7:15–22.CrossRefPubMed
46.
go back to reference Ospanov O, Maleckas A, Orekeshova A. Gastric greater curvature plication combined with Nissen fundoplication in the treatment of gastroesophageal reflux disease and obesity. Medicina. 2016;52:283–90.CrossRefPubMed Ospanov O, Maleckas A, Orekeshova A. Gastric greater curvature plication combined with Nissen fundoplication in the treatment of gastroesophageal reflux disease and obesity. Medicina. 2016;52:283–90.CrossRefPubMed
47.
go back to reference Frantzides CT, Carlson MA, Madan AK, et al. Selective use of esophageal manometry and 24-hour pH monitoring before laparoscopic fundoplication. J Am Coll Surg. 2003;197:358–63. discussion 354–63CrossRefPubMed Frantzides CT, Carlson MA, Madan AK, et al. Selective use of esophageal manometry and 24-hour pH monitoring before laparoscopic fundoplication. J Am Coll Surg. 2003;197:358–63. discussion 354–63CrossRefPubMed
48.
go back to reference Yang H, Watson DI, Kelly J, et al. Esophageal manometry and clinical outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg. 2007;11:1126–33.CrossRefPubMed Yang H, Watson DI, Kelly J, et al. Esophageal manometry and clinical outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg. 2007;11:1126–33.CrossRefPubMed
49.
go back to reference Fibbe C, Layer P, Keller J, et al. Esophageal motility in reflux disease before and after fundoplication: a prospective, randomized, clinical, and manometric study. Gastroenterology. 2001;121:5–14.CrossRefPubMed Fibbe C, Layer P, Keller J, et al. Esophageal motility in reflux disease before and after fundoplication: a prospective, randomized, clinical, and manometric study. Gastroenterology. 2001;121:5–14.CrossRefPubMed
Metadata
Title
Laparoscopic Nissen Fundoplication Plus Mid-gastric Plication for Treatment of Obese Patients with Gastroesophageal Reflux Disease
Authors
Ahmed Talha
Mohammed Ibrahim
Publication date
01-02-2018
Publisher
Springer US
Published in
Obesity Surgery / Issue 2/2018
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-017-2862-8

Other articles of this Issue 2/2018

Obesity Surgery 2/2018 Go to the issue