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Published in: Strahlentherapie und Onkologie 2/2018

01-02-2018 | Literatur kommentiert

Langzeitergebnisse der adjuvanten im Vergleich zur Early-Salvage-Bestrahlung beim pT3N0-Prostatakarzinom nach radikaler Prostatektomie

Authors: Prof. Dr. med. R. M. Hermann, Prof. Dr. med. H. Christiansen

Published in: Strahlentherapie und Onkologie | Issue 2/2018

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Die optimale postoperative Behandlung von Patienten mit lokal fortgeschrittenen, aber noch nodal-negativen Prostatakarzinomen ist derzeit nicht geklärt. Neben der „sofortigen“ adjuvanten Bestrahlung (aRT) der ehemaligen Prostataloge (eingeleitet nach Rehabilitation des Blasenschlusses, bei einem postoperativen Wert des prostataspezifischen Antigens [PSA] im Nullbereich) kann auch die engmaschige PSA-Nachsorge mit einer bei Anstieg der Werte (≤0,5 ng/ml) frühzeitig eingeleiteten „Rettungsbestrahlung“ (Early-Salvage-Bestrahlung, esRT) gut begründet werden. Da bislang noch keine Ergebnisse prospektiv randomisierter Studien zu dieser Frage vorliegen, sollten durch eine möglichst groß angelegte retrospektive Studie beide Konzepte miteinander verglichen werden. …
Literature
1.
go back to reference Bolla M, Van Poppel H, Tombal B et al (2012) Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911). Lancet 380:2018–2027CrossRefPubMed Bolla M, Van Poppel H, Tombal B et al (2012) Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911). Lancet 380:2018–2027CrossRefPubMed
2.
go back to reference Wiegel T, Bartkowiak D, Bottke D et al (2014) Adjuvant radiotherapy versus wait-and-see after radical prostatectomy: 10-year follow-up of the ARO 96-02/AUO AP 09/95 trial. Eur Urol 66:243–250CrossRefPubMed Wiegel T, Bartkowiak D, Bottke D et al (2014) Adjuvant radiotherapy versus wait-and-see after radical prostatectomy: 10-year follow-up of the ARO 96-02/AUO AP 09/95 trial. Eur Urol 66:243–250CrossRefPubMed
3.
go back to reference Thompson IM, Tangen CM, Paradelo J et al (2009) Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial. J Urol 181:956–962CrossRefPubMedPubMedCentral Thompson IM, Tangen CM, Paradelo J et al (2009) Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial. J Urol 181:956–962CrossRefPubMedPubMedCentral
4.
go back to reference Zakeri K, Rose BS, Gulaya S et al (2013) Competing event risk stratification may improve the design and efficiency of clinical trials: secondary analysis of SWOG 8794. Contemp Clin Trials 34:74–79CrossRefPubMed Zakeri K, Rose BS, Gulaya S et al (2013) Competing event risk stratification may improve the design and efficiency of clinical trials: secondary analysis of SWOG 8794. Contemp Clin Trials 34:74–79CrossRefPubMed
6.
go back to reference King CR (2012) The timing of salvage radiotherapy after radical prostatectomy: a systematic review. Int J Radiat Oncol Biol Phys 84:104–111CrossRefPubMed King CR (2012) The timing of salvage radiotherapy after radical prostatectomy: a systematic review. Int J Radiat Oncol Biol Phys 84:104–111CrossRefPubMed
7.
go back to reference Ohri N, Dicker AP, Trabulsi EJ et al (2012) Can early implementation of salvage radiotherapy for prostate cancer improve the therapeutic ratio? A systematic review and regression meta-analysis with radiobiological modelling. Eur J Cancer 48:837–844CrossRefPubMed Ohri N, Dicker AP, Trabulsi EJ et al (2012) Can early implementation of salvage radiotherapy for prostate cancer improve the therapeutic ratio? A systematic review and regression meta-analysis with radiobiological modelling. Eur J Cancer 48:837–844CrossRefPubMed
8.
go back to reference Kang JJ, Reiter RE, Steinberg ML et al (2015) Ultrasensitive prostate specific antigen after prostatectomy reliably identifies patients requiring postoperative radiotherapy. J Urol 193:1532–1538CrossRefPubMed Kang JJ, Reiter RE, Steinberg ML et al (2015) Ultrasensitive prostate specific antigen after prostatectomy reliably identifies patients requiring postoperative radiotherapy. J Urol 193:1532–1538CrossRefPubMed
9.
go back to reference Budäus L, Schiffmann J, Graefen M, Huland H, Tennstedt P, Siegmann A, Böhmer D, Budach V, Bartkowiak D, Wiegel T (2017) Defining biochemical recurrence after radical prostatectomy and timing of early salvage radiotherapy: informing the debate. Strahlenther Onkol. https://doi.org/10.1007/s00066-017-1140-y PubMed Budäus L, Schiffmann J, Graefen M, Huland H, Tennstedt P, Siegmann A, Böhmer D, Budach V, Bartkowiak D, Wiegel T (2017) Defining biochemical recurrence after radical prostatectomy and timing of early salvage radiotherapy: informing the debate. Strahlenther Onkol. https://​doi.​org/​10.​1007/​s00066-017-1140-y PubMed
10.
go back to reference Briganti A, Wiegel T, Joniau S et al (2012) Early salvage radiation therapy does not compromise cancer control in patients with pT3N0 prostatecancer after radical prostatectomy: results of a match-controlledmulti-institutional analysis. Eur Urol 62:472–487CrossRefPubMed Briganti A, Wiegel T, Joniau S et al (2012) Early salvage radiation therapy does not compromise cancer control in patients with pT3N0 prostatecancer after radical prostatectomy: results of a match-controlledmulti-institutional analysis. Eur Urol 62:472–487CrossRefPubMed
Metadata
Title
Langzeitergebnisse der adjuvanten im Vergleich zur Early-Salvage-Bestrahlung beim pT3N0-Prostatakarzinom nach radikaler Prostatektomie
Authors
Prof. Dr. med. R. M. Hermann
Prof. Dr. med. H. Christiansen
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 2/2018
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-017-1242-6

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