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Child's Nervous System

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01-02-2019 | Original Paper

Lack of relationship between cord blood erythropoietin and intraventricular hemorrhage in premature neonates: a controversial result

Authors: Khadijehsadat Najib, Zahra Hashemi, Mozhgan Moghtaderi, Parisa Pishdad, Narjes Pishva, Fatemehsadat Najib

Published in: Child's Nervous System | Issue 2/2019

Abstract

Purpose

The aim of this study was to assess the incidence and risk factors of intraventricular hemorrhage (IVH) as well as the role of cord blood erythropoietin (EPO) level in predicting the possibility of IVH in premature neonates.

Materials and methods

This prospective study included 140 preterm neonates born at hospitals affiliated to Shiraz University of Medical Sciences from May 2014 to April 2015. Complete blood count and cord blood EPO level was measured after birth. Brain ultrasonography was performed at 3 and 7–10 days after birth in these newborns.

Results

Brain ultrasonography showed IVH in 8.57% (12/140) until the third day and 20% (28/140) at 7–10 days of life in premature neonates. Early gestational age, low birth weight, low Apgar score, and failure to give prenatal steroid were significant risk factors for developing IVH. The mean level of cord blood EPO was 20.95 ± 21.09 mIU/mL in premature newborns without IVH and 15.82 ± 17.11 mIU/mL with IVH. There was no correlation between the cord blood EPO and IVH in premature newborns.

Conclusion

Antenatal steroids therapy should be encouraged among women at risk of premature delivery. Our results showed that the cord blood EPO was not correlated with IVH in preterm neonates and further research is required to assess this relationship.

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Title: Lack of relationship between cord blood erythropoietin and intraventricular hemorrhage in premature neonates: a controversial result
Authors: Khadijehsadat Najib
Zahra Hashemi
Mozhgan Moghtaderi
Parisa Pishdad
Narjes Pishva
Fatemehsadat Najib
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 2/2019
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-018-3872-0

At a glance: The STEP trials

Springer Medicine

Lack of relationship between cord blood erythropoietin and intraventricular hemorrhage in premature neonates: a controversial result

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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