Top

European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-01-2008 | Focus on

Labeling peptides with PET radiometals: Vulcan’s forge

Author: Giovanni Lucignani

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 1/2008

Excerpt

The most commonly used positron emitting radionuclide is ¹⁸F, and ¹⁸F-labeled fluorodeoxyglucose (FDG) is the dominating positron emission tomography (PET) tracer in oncology. The use of FDG is supported by the supply of ¹⁸F through hundreds of cyclotrons located in academic centers and industrial settings worldwide. With advances in PET research it has been repeatedly suggested that various peptides that might be more specific than FDG in oncologic studies could be labeled with positron emitting radiometals. …

Dijkgraaf I, Boerman OC, Oyen WJ, Corstens FH, Gotthardt M. Development and application of peptide-based radiopharmaceuticals. Anticancer Agents Med Chem 2007;7(5):543–51. Sep.PubMed

Wadas TJ, Wong EH, Weisman GR, Anderson CJ. Copper chelation chemistry and its role in copper radiopharmaceuticals. Curr Pharm Des 2007;13(1):3–16.PubMedCrossRef

Chong HS, Mhaske S, Lin M, Bhuniya S, Song HA, Brechbiel MW, et al. Novel synthetic ligands for targeted PET imaging and radiotherapy of copper. Bioorg Med Chem Lett 2007;17(22):6107–10. Epub 2007 Sep 18, Nov 15.PubMedCrossRef

Win Z, Al-Nahhas A, Rubello D, Gross MD. Somatostatin receptor PET imaging with Gallium-68 labeled peptides. Q J Nucl Med Mol Imaging 2007;51(3):244–50. Epub 2007 Apr 30, Sep.PubMed

Parry JJ, Kelly TS, Andrews R, Rogers BE. In vitro and in vivo evaluation of ⁶⁴Cu-labeled DOTA-linker-bombesin(7–14) analogues containing different amino acid linker moieties. Bioconjug Chem 2007;18(4):1110–7. Epub 2007 May 16, Jul–Aug.PubMedCrossRef

Sprague JE, Peng Y, Fiamengo AL, Woodin KS, Southwick EA, Weisman GR, et al. Synthesis, characterization and in vivo studies of Cu(II)-64-labeled cross-bridged tetraazamacrocycle-amide complexes as models of peptide conjugate imaging agents. J Med Chem 2007;50(10):2527–35. Epub 2007 Apr 26, May 17.PubMedCrossRef

Garrison JC, Rold TL, Sieckman GL, Figueroa SD, Volkert WA, Jurisson SS, et al. In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using ⁶⁴Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems. J Nucl Med 2007;48(8):1327–37. Epub 2007 Jul 13, Aug.PubMedCrossRef

Prasanphanich AF, Nanda PK, Rold TL, Ma L, Lewis MR, Garrison JC, et al. [⁶⁴Cu-NOTA-8-Aoc-BBN(7–14)NH2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues. Proc Natl Acad Sci USA 2007;104(30):12462–7. Epub 2007 Jul 12, Jul 24.PubMedCrossRef

Biddlecombe GB, Rogers BE, de Visser M, Parry JJ, de Jong M, Erion JL, et al. Molecular imaging of gastrin-releasing peptide receptor-positive tumors in mice using ⁶⁴Cu-and ⁸⁶Y-DOTA-(Pro1,Tyr4)-bombesin(1–14). Bioconjug Chem 2007;18(3):724–30. Epub 2007 Mar 23, May–Jun.PubMedCrossRef

10.

Li ZB, Cai W, Cao Q, Chen K, Wu Z, He L, et al. ⁶⁴Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med 2007;48(7):1162–71. Epub 2007 Jun 15, Jul.PubMedCrossRef

11.

Cai W, Ebrahimnejad A, Chen K, Cao Q, Li ZB, Tice DA, et al. Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice. Eur J Nucl Med Mol Imaging 2007;in press.

12.

Cai W, Chen K, He L, Cao Q, Koong A, Chen X. Quantitative PET of EGFR expression in xenograft-bearing mice using ⁶⁴Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody. Eur J Nucl Med Mol Imaging. 2007;34(6):850–8. Epub 2007 Jan 30, Jun.PubMedCrossRef

13.

Maecke HR, Andre JP. ⁶⁸Ga-PET radiopharmacy: a generator-based alternative to 18F-radiopharmacy. Ernst Schering Res Found Workshop 2007. (62):215–42.

14.

Breeman WA, Verbruggen AM. The ⁶⁸Ge/⁶⁸Ga generator has high potential, but when can we use ⁶⁸Ga-labelled tracers in clinical routine? Eur J Nucl Med Mol Imaging 2007;34:978–81.PubMedCrossRef

15.

Zhernosekov KP, Filosofov DV, Baum RP, Aschoff P, Bihl H, Razbash AA, et al. Processing of generator-produced ⁶⁸Ga for medical application. J Nucl Med 2007;48(10):1741–8. Oct.PubMedCrossRef

16.

Azhdarinia A, Yang DJ, Chao C, Mourtada F. Infrared-based module for the synthesis of 68Ga-labeled radiotracers. Nucl Med Biol 2007;34(1):121–7. Jan.PubMedCrossRef

17.

Decristoforo C, Knopp R, von Guggenberg E, Rupprich M, Dreger T, Hess A, et al. A fully automated synthesis for the preparation of ⁶⁸Ga-labelled peptides. Nucl Med Commun 2007;28(11):870–5. Nov.PubMedCrossRef

18.

Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, et al. ⁶⁸Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med 2007;48(4):508–18. Apr.PubMedCrossRef

19.

Zhang H, Schuhmacher J, Waser B, Wild D, Eisenhut M, Reubi JC, et al. DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours. Eur J Nucl Med Mol Imaging 2007;34(8):1198–208. Epub 2007 Jan 30, Aug.PubMedCrossRef

20.

Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, et al. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? Eur J Nucl Med Mol Imaging 2007;34(7):982–93. Epub 2007 Jan 16, Jul.PubMedCrossRef

21.

http://en.wikipedia.org/wiki/Vulcan_%28mythology%29

Title: Labeling peptides with PET radiometals: Vulcan’s forge
Author: Giovanni Lucignani
Publication date: 01-01-2008
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 1/2008
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-007-0656-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Labeling peptides with PET radiometals: Vulcan’s forge

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 1/2008

Activity-based costing evaluation of [18F]-fludeoxyglucose production

The detection rate of [11C]Choline-PET/CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer

Metabolic–dopaminergic mapping of the 6-hydroxydopamine rat model for Parkinson’s disease

68Ga-DOTANOC: biodistribution and dosimetry in patients affected by neuroendocrine tumors

Prognostic value of 99mTc-HYNIC Annexin-V imaging in squamous cell carcinoma of the head and neck

Intra-individual comparison of p-[123I]-iodo-L-phenylalanine and L-3-[123I]-iodo-α-methyl-tyrosine for SPECT imaging of gliomas