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Published in: Pediatric Nephrology 6/2018

01-06-2018 | Original Article

Klotho G-395A gene polymorphism: impact on progression of end-stage renal disease and development of cardiovascular complications in children on dialysis

Authors: Eman A. Elghoroury, Fatina I. Fadel, Manal F. Elshamaa, Dina Kandil, Doaa M. Salah, Marwa M. El-Sonbaty, Hebatallah Farouk, Mona Raafat, Soha Nasr

Published in: Pediatric Nephrology | Issue 6/2018

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Abstract

Background

Klotho G-395-A gene polymorphism may impact children with end-stage renal disease (ESRD). We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients.

Methods

Fifty-five children with chronic kidney disease (CKD) and seventy healthy children were genotyped for Klotho G-395A.

Results

Incidence of GA/AA genotypes and A allele were higher in ESRD patients compared with controls (54.5 vs. 7.1%, P < 0.001; 30.9 vs. 13.6%, P = 0.001, respectively). Also, children with GA/AA genotypes were 15.6 times more likely to develop ESRD than with GG genotype (95% CI 5.4–44.7, P < 0.001). A allele carriers have 2.8 times higher risk of developing ESRD than those with G allele (95% CI 1.5–5.35, P = 0.001). Also, the A allele could be considered a predictor of cardiovascular disease (CVD), as carriers have 161 times higher risk of cardiovascular complications than non-carriers (95% CI 21–1233, P < 0.001). All ESRD patients with CVD presented with left ventricular hypertrophy (LVH) and the frequency of A allele was significantly higher among ESRD children with LVH, whereas G allele frequency was significantly higher among ESRD children without LVH.

Conclusions

The A allele of the G-395A Klotho gene polymorphism shows a significantly higher frequency among children with CKD and those with CVD and LVH. This mutant allele could be used as a risk marker for the development of ESRD as well as a predictor of CVD in these children.
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Metadata
Title
Klotho G-395A gene polymorphism: impact on progression of end-stage renal disease and development of cardiovascular complications in children on dialysis
Authors
Eman A. Elghoroury
Fatina I. Fadel
Manal F. Elshamaa
Dina Kandil
Doaa M. Salah
Marwa M. El-Sonbaty
Hebatallah Farouk
Mona Raafat
Soha Nasr
Publication date
01-06-2018
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 6/2018
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-017-3877-z

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