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Published in: European Journal of Trauma and Emergency Surgery 2/2017

01-04-2017 | Original Article

Kinetic therapy in multiple trauma patients with severe thoracic trauma: a treatment option to reduce ventilator time and improve outcome

Authors: S. Wutzler, K. Sturm, T. Lustenberger, H. Wyen, K. Zacharowksi, I. Marzi, T. Bingold

Published in: European Journal of Trauma and Emergency Surgery | Issue 2/2017

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Abstract

Purpose

Continuous lateral rotational therapy (CLRT) has been described as a promising approach for prophylaxis and treatment of respiratory complications in critically ill patients over two decades ago. However, meta-analyses failed to demonstrate any significant benefit on outcome by CLRT, possibly due to the heterogeneity and low overall quality of available studies.

Methods

Observational trial over a 3-year period on outcome in trauma patients (Injury Severity Score, ISS ≥16) with severe thoracic injury (Abbreviated Injury Scale, AISThorax ≥3) initially treated with CLRT as standard of care. Epidemiological data, injury severity, and pattern and physiological parameters were recorded. Outcome indicators were time on mechanical ventilation, length of stay, rates of pneumonia, sepsis and acute respiratory distress syndrome, hospital mortality, and rates of re-intubation. Additionally, data are compared with the results from the TraumaRegister® of the German Trauma Society.

Results

Over the 3-year period 76 patients with ISS ≥16/AISThorax ≥3 received CLRT, equaling 24 % of all patients with ISS ≥16 between 18 and 80 years. Mean ISS was 35.3 (standard deviations, SD 12.2) [71.1 % male, 97.4 % blunt trauma, mean age 43.9 years (SD 18.7)]. Mean time on CLRT was 3.3 days (SD 2.2), time on mechanical ventilation 7.8 days (SD 7.1), and 9.2 % had to be re-intubated due to respiratory complications. CLRT-related complications occurred in 8.9 %. Overall 25 % of the patients developed pneumonia (VAP = 13.2 %). Despite a significantly higher ISS we observed shorter times on mechanical ventilation and intensive care unit in our collective in comparison to data published from the nationwide TraumaRegister®.

Conclusions

CLRT remains a therapeutic option to reduce pulmonary complications after severe chest trauma in our center. However, a RCT is needed to study the effects of other treatment options such as early extubation and non-invasive ventilation or prone/supine positioning.
Literature
1.
go back to reference Hildebrand F, Giannoudis PV, Griensven M, et al. Management of polytraumatized patients with associated blunt chest trauma: a comparison of two European countries. Injury. 2005;36(2):293–302.CrossRefPubMed Hildebrand F, Giannoudis PV, Griensven M, et al. Management of polytraumatized patients with associated blunt chest trauma: a comparison of two European countries. Injury. 2005;36(2):293–302.CrossRefPubMed
2.
go back to reference Wutzler S, Lehnert T, Laurer H, et al. Circulating levels of Clara cell protein 16 but not surfactant protein D identify and quantify lung damage in patients with multiple injuries. J Trauma. 2011;71(2):E31–6.CrossRefPubMed Wutzler S, Lehnert T, Laurer H, et al. Circulating levels of Clara cell protein 16 but not surfactant protein D identify and quantify lung damage in patients with multiple injuries. J Trauma. 2011;71(2):E31–6.CrossRefPubMed
3.
go back to reference Wutzler S, Wafaisade A, Maegele M, et al. Lung Organ Failure Score (LOFS): probability of severe pulmonary organ failure after multiple injuries including chest trauma. Injury. 2012;43(9):1507–12.CrossRefPubMed Wutzler S, Wafaisade A, Maegele M, et al. Lung Organ Failure Score (LOFS): probability of severe pulmonary organ failure after multiple injuries including chest trauma. Injury. 2012;43(9):1507–12.CrossRefPubMed
6.
go back to reference Maier M, Geiger EV, Wutzler S, et al. Role of lung contusions on posttraumatic inflammatory response and organ dysfunction in traumatized patients. Eur J Trauma Emerg Surg. 2009;35:463–9.CrossRefPubMed Maier M, Geiger EV, Wutzler S, et al. Role of lung contusions on posttraumatic inflammatory response and organ dysfunction in traumatized patients. Eur J Trauma Emerg Surg. 2009;35:463–9.CrossRefPubMed
7.
go back to reference Moloney JT, Fowler SJ, Chang W. Anesthetic management of thoracic trauma. Curr Opin Anaesthesiol. 2008;21(1):41–6.CrossRefPubMed Moloney JT, Fowler SJ, Chang W. Anesthetic management of thoracic trauma. Curr Opin Anaesthesiol. 2008;21(1):41–6.CrossRefPubMed
8.
go back to reference Ahrens T, Kollef M, Stewart J, et al. Effect of kinetic therapy on pulmonary complications. Am J Crit Care. 2004;13(5):376–83.PubMed Ahrens T, Kollef M, Stewart J, et al. Effect of kinetic therapy on pulmonary complications. Am J Crit Care. 2004;13(5):376–83.PubMed
9.
go back to reference Davis JW, Lemaster DM, Moore EC, et al. Prone ventilation in trauma or surgical patients with acute lung injury and adult respiratory distress syndrome: is it beneficial? J Trauma. 2007;62(5):1201–6.CrossRefPubMed Davis JW, Lemaster DM, Moore EC, et al. Prone ventilation in trauma or surgical patients with acute lung injury and adult respiratory distress syndrome: is it beneficial? J Trauma. 2007;62(5):1201–6.CrossRefPubMed
10.
go back to reference Goldhill DR, Imhoff M, McLean B, et al. Rotational bed therapy to prevent and treat respiratory complications: a review and meta-analysis. Am J Crit Care. 2007;16(1):50–61.PubMed Goldhill DR, Imhoff M, McLean B, et al. Rotational bed therapy to prevent and treat respiratory complications: a review and meta-analysis. Am J Crit Care. 2007;16(1):50–61.PubMed
11.
go back to reference Johnson KL, Meyenburg T. Physiological rationale and current evidence for therapeutic positioning of critically ill patients. AACN Adv Crit Care. 2009;20(3):228–40.PubMed Johnson KL, Meyenburg T. Physiological rationale and current evidence for therapeutic positioning of critically ill patients. AACN Adv Crit Care. 2009;20(3):228–40.PubMed
12.
go back to reference Delaney A, Gray H, Laupland KB, et al. Kinetic bed therapy to prevent nosocomial pneumonia in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care. 2006;10(3):R70.CrossRefPubMedPubMedCentral Delaney A, Gray H, Laupland KB, et al. Kinetic bed therapy to prevent nosocomial pneumonia in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care. 2006;10(3):R70.CrossRefPubMedPubMedCentral
13.
go back to reference Stiletto R, Gotzen L, Goubeaud S. Kinetic therapy for therapy and prevention of post-traumatic lung failure. Results of a prospective study of 111 polytrauma patients. Unfallchirurg. 2000;103(12):1057–64.CrossRefPubMed Stiletto R, Gotzen L, Goubeaud S. Kinetic therapy for therapy and prevention of post-traumatic lung failure. Results of a prospective study of 111 polytrauma patients. Unfallchirurg. 2000;103(12):1057–64.CrossRefPubMed
14.
go back to reference Wyen H, Wutzler S, Maegele M, et al. Rotational bed therapy after blunt chest trauma: a nationwide online-survey on current concepts of care in Germany. Injury. 2013;44(1):70–4.CrossRefPubMed Wyen H, Wutzler S, Maegele M, et al. Rotational bed therapy after blunt chest trauma: a nationwide online-survey on current concepts of care in Germany. Injury. 2013;44(1):70–4.CrossRefPubMed
15.
go back to reference Baker SP, O’Neill B, Haddon W Jr, et al. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14(3):187–96.CrossRefPubMed Baker SP, O’Neill B, Haddon W Jr, et al. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14(3):187–96.CrossRefPubMed
16.
go back to reference Association for the Advancement in Automotive Medicine. Abbreviated Injury Scale (AIS) 1990 revision—update 1998. Barlington, 1998. Association for the Advancement in Automotive Medicine. Abbreviated Injury Scale (AIS) 1990 revision—update 1998. Barlington, 1998.
17.
go back to reference Bernard GR, Artigas A, Brigham KL, et al. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. Consensus Comm Intensive Care Med. 1994;20(3):225–32.CrossRef Bernard GR, Artigas A, Brigham KL, et al. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. Consensus Comm Intensive Care Med. 1994;20(3):225–32.CrossRef
18.
go back to reference Vincent JL, Moreno R, Takala J, et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European society of intensive care medicine. Intensive Care Med. 1996;22(7):707–10.CrossRefPubMed Vincent JL, Moreno R, Takala J, et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European society of intensive care medicine. Intensive Care Med. 1996;22(7):707–10.CrossRefPubMed
19.
go back to reference Schurink CA, Van Nieuwenhoven CA, Jacobs JA, et al. Clinical pulmonary infection score for ventilator-associated pneumonia: accuracy and inter-observer variability. Intensive Care Med. 2004;30(2):217–24.CrossRefPubMed Schurink CA, Van Nieuwenhoven CA, Jacobs JA, et al. Clinical pulmonary infection score for ventilator-associated pneumonia: accuracy and inter-observer variability. Intensive Care Med. 2004;30(2):217–24.CrossRefPubMed
20.
go back to reference Pugin J, Auckenthaler R, Mili N, et al. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic “blind” bronchoalveolar lavage fluid. Am Rev Respir Dis. 1991;143(5 Pt 1):1121–9.CrossRefPubMed Pugin J, Auckenthaler R, Mili N, et al. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic “blind” bronchoalveolar lavage fluid. Am Rev Respir Dis. 1991;143(5 Pt 1):1121–9.CrossRefPubMed
21.
go back to reference Nelson LD, Choi SC. Kinetic therapy in critically ill trauma patients. Clin Intensive Care. 1992;3(6):248–52.PubMed Nelson LD, Choi SC. Kinetic therapy in critically ill trauma patients. Clin Intensive Care. 1992;3(6):248–52.PubMed
22.
go back to reference Rubano JA, Paccione MF, Rutigliano DN, et al. Outcomes following prolonged mechanical ventilation: analysis of a countywide trauma registry. J Trauma Acute Care Surg. 2015;78(2):289–94.CrossRefPubMed Rubano JA, Paccione MF, Rutigliano DN, et al. Outcomes following prolonged mechanical ventilation: analysis of a countywide trauma registry. J Trauma Acute Care Surg. 2015;78(2):289–94.CrossRefPubMed
23.
go back to reference Mohr NM, Harland KK, Skeete D, et al. Duration of prehospital intubation is not a risk factor for development of early ventilator-associated pneumonia. J Crit Care. 2014;29(4):539–44.CrossRefPubMed Mohr NM, Harland KK, Skeete D, et al. Duration of prehospital intubation is not a risk factor for development of early ventilator-associated pneumonia. J Crit Care. 2014;29(4):539–44.CrossRefPubMed
24.
go back to reference Miller PR, Croce MA, Bee TK, et al. ARDS after pulmonary contusion: accurate measurement of contusion volume identifies high-risk patients. J Trauma. 2001;51(2):223–8.CrossRefPubMed Miller PR, Croce MA, Bee TK, et al. ARDS after pulmonary contusion: accurate measurement of contusion volume identifies high-risk patients. J Trauma. 2001;51(2):223–8.CrossRefPubMed
25.
go back to reference Alsaghir AH, Martin CM. Effect of prone positioning in patients with acute respiratory distress syndrome: a meta-analysis. Crit Care Med. 2008;36(2):603–9.CrossRefPubMed Alsaghir AH, Martin CM. Effect of prone positioning in patients with acute respiratory distress syndrome: a meta-analysis. Crit Care Med. 2008;36(2):603–9.CrossRefPubMed
26.
go back to reference Abroug F, Ouanes-Besbes L, Elatrous S, et al. The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research. Intensive Care Med. 2008;34(6):1002–11.CrossRefPubMed Abroug F, Ouanes-Besbes L, Elatrous S, et al. The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research. Intensive Care Med. 2008;34(6):1002–11.CrossRefPubMed
27.
go back to reference Tiruvoipati R, Bangash M, Manktelow B, et al. Efficacy of prone ventilation in adult patients with acute respiratory failure: a meta-analysis. J Crit Care. 2008;23(1):101–10.CrossRefPubMed Tiruvoipati R, Bangash M, Manktelow B, et al. Efficacy of prone ventilation in adult patients with acute respiratory failure: a meta-analysis. J Crit Care. 2008;23(1):101–10.CrossRefPubMed
28.
go back to reference Abroug F, Ouanes-Besbes L, Dachraoui F, et al. An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury. Crit Care. 2011;15(1):R6.CrossRefPubMedPubMedCentral Abroug F, Ouanes-Besbes L, Dachraoui F, et al. An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury. Crit Care. 2011;15(1):R6.CrossRefPubMedPubMedCentral
29.
go back to reference Lee JM, Bae W, Lee YJ, et al. The efficacy and safety of prone positional ventilation in acute respiratory distress syndrome: updated study-level meta-analysis of 11 randomized controlled trials. Crit Care Med. 2014;42(5):1252–62.CrossRefPubMed Lee JM, Bae W, Lee YJ, et al. The efficacy and safety of prone positional ventilation in acute respiratory distress syndrome: updated study-level meta-analysis of 11 randomized controlled trials. Crit Care Med. 2014;42(5):1252–62.CrossRefPubMed
30.
go back to reference Agarwal R, Aggarwal AN, Gupta D. Role of noninvasive ventilation in acute lung injury/acute respiratory distress syndrome: a proportion meta-analysis. Respir Care. 2010;55(12):1653–60.PubMed Agarwal R, Aggarwal AN, Gupta D. Role of noninvasive ventilation in acute lung injury/acute respiratory distress syndrome: a proportion meta-analysis. Respir Care. 2010;55(12):1653–60.PubMed
31.
go back to reference Agarwal R, Reddy C, Aggarwal AN, et al. Is there a role for noninvasive ventilation in acute respiratory distress syndrome? A meta-analysis. Respir Med. 2006;100(12):2235–8.PubMed Agarwal R, Reddy C, Aggarwal AN, et al. Is there a role for noninvasive ventilation in acute respiratory distress syndrome? A meta-analysis. Respir Med. 2006;100(12):2235–8.PubMed
32.
go back to reference Roberts S, Skinner D, Biccard B, et al. The role of non-invasive ventilation in blunt chest trauma: systematic review and met-analysis. Eur J Trauma Emerg Surg. 2014;40:553–9.CrossRefPubMed Roberts S, Skinner D, Biccard B, et al. The role of non-invasive ventilation in blunt chest trauma: systematic review and met-analysis. Eur J Trauma Emerg Surg. 2014;40:553–9.CrossRefPubMed
Metadata
Title
Kinetic therapy in multiple trauma patients with severe thoracic trauma: a treatment option to reduce ventilator time and improve outcome
Authors
S. Wutzler
K. Sturm
T. Lustenberger
H. Wyen
K. Zacharowksi
I. Marzi
T. Bingold
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Trauma and Emergency Surgery / Issue 2/2017
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-016-0692-3

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