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BMC Medical Informatics and Decision Making

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Open Access 01-12-2020 | Kidney Transplantation | Research article

ICT-based adherence monitoring in kidney transplant recipients: a randomized controlled trial

Authors: Hee-Yeon Jung, Yena Jeon, Sook Jin Seong, Jung Ju Seo, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim, Young-Ran Yoon, Se-Hee Yoon, Jong Soo Lee, Yong-Lim Kim

Published in: BMC Medical Informatics and Decision Making | Issue 1/2020

Abstract

Background

Prior studies have explored the use of regular reminders to improve adherence among kidney transplant recipients (KTRs), but none have included real-time alarms about drug dosage, frequency, and interval. In the present study, we aimed to evaluate the efficacy and stability of an information and communication technology (ICT)-based centralized monitoring system for increasing medication adherence among Korean KTRs.

Methods

In this prospective, multicenter, randomized controlled study, enrolled KTRs were randomized to either the ICT-based centralized monitoring group or control group. The ICT-based centralized monitoring system alerted both patients and medical staff with texts and pill box alarms if there was a missed dose or a dosage/time error. We compared the two groups in terms of medication adherence and transplant outcomes over 6 months, and evaluated patient satisfaction with the ICT-based monitoring system.

Results

Among 114 enrolled KTRs, 57 were assigned to the ICT-based centralized monitoring group and 57 to the control group. The two groups did not significantly differ in mean adherence at each follow-up visit. The intrapatient variability of tacrolimus and mycophenolic acid levels, renal function, and adverse transplant outcomes did not differ between the intervention and control groups, or between the intervention group with feedback generation and the intervention group without feedback generation. Patients showed high overall satisfaction with the ICT-based centralized monitoring system, which significantly improved across the study period (p = 0.012).

Conclusions

Due to high baseline adherence, the ICT-based centralized monitoring system did not maximize medication adherence or enhance transplant outcomes among Korean KTRs. However, patients were highly satisfied with the system. Our results suggest that the ICT-based centralized monitoring system could be successfully applied in clinical trials.

Trial registration

ClinicalTrials.gov, NCT03136588. Registered 20 April 2017 - Retrospectively registered.

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Title: ICT-based adherence monitoring in kidney transplant recipients: a randomized controlled trial
Authors: Hee-Yeon Jung
Yena Jeon
Sook Jin Seong
Jung Ju Seo
Ji-Young Choi
Jang-Hee Cho
Sun-Hee Park
Chan-Duck Kim
Young-Ran Yoon
Se-Hee Yoon
Jong Soo Lee
Yong-Lim Kim
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Kidney Transplantation
Kidney Transplantation
Kidney Transplantation
Kidney Transplantation
Kidney Transplantation
Kidney Transplantation
Tacrolimus
Published in: BMC Medical Informatics and Decision Making / Issue 1/2020
Electronic ISSN: 1472-6947
DOI: https://doi.org/10.1186/s12911-020-01146-6

At a glance: The STEP trials

Springer Medicine

ICT-based adherence monitoring in kidney transplant recipients: a randomized controlled trial

Abstract

Background

Methods

Results

Conclusions

Trial registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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