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BMC Cancer
Published in: BMC Cancer 1/2023

Open Access 01-12-2023 | Kidney Cancer | Research

Characterization of renal artery variation in patients with clear cell renal cell carcinoma and the predictive value of accessory renal artery in pathological grading of renal cell carcinoma: a retrospective and observational study

Authors: Dingyang Lv, Huiyu Zhou, Fan Cui, Jie Wen, Weibing Shuang

Published in: BMC Cancer | Issue 1/2023

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Abstract

Objective

To explore the characteristics of renal artery variation in patients with renal cell carcinoma and to evaluate the predicting value of accessory renal artery in the pathological grading of renal cell carcinoma.

Methods

The clinicopathological data of patients with clear cell renal cell carcinoma diagnosed in the Department of Urology of the First Hospital of Shanxi Medical University from September 2019 to March 2023 were retrospectively analyzed. All patients underwent visual three-dimensional model reconstruction from computed tomography images. All kidneys were divided into two groups: the affected kidney and the healthy kidney, and the incidence of renal artery variation in the two groups was analyzed. Then, according to the existence of accessory renal artery in the affected kidney, the patients were divided into two groups, and the relationship between accessory renal artery and clinicopathological features of patients with clear cell renal cell carcinoma was analyzed. Finally, univariate and multivariate logistic regression analyses were performed to determine the predictors of Fuhrman grading of clear cell renal cell carcinoma, and the predictive ability of the model was evaluated by the receiver operating characteristic curve.

Results

The incidence of renal artery variation and accessory renal artery in the affected kidney was significantly higher than them in the healthy kidney. The patients with accessory renal artery in the affected kidney had larger tumor maximum diameter, higher Fuhrman grade and more exophytic growth. The presence of accessory renal artery on the affected kidney and the maximum diameter of tumor are independent predictors of high-grade renal cell carcinoma. The receiver operating characteristic curve suggests that the model has a good predictive ability.

Conclusion

The existence of accessory renal artery on the affected kidney may be related to the occurrence and development of clear cell renal cell carcinoma, and can better predict Fuhrman grade of clear cell renal cell carcinoma. The finding provides a reference for the future diagnostic evaluation of RCC, and provides a new direction for the study of the pathogenesis of RCC.
Literature
1.
2.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. The 2016 WHO classification of tumours of the urinary system and male genital organs-part A: renal, penile, and testicular tumours. Eur Urol. 2016;70(1):93–105.CrossRefPubMed
3.
Liatsikos E, Kallidonis P, Do M, Dietel A, Al-Aown A, Constantinidis C, et al. Laparoscopic radical and partial nephrectomy: technical issues and outcome. World J Urol. 2013;31(4):785–91.CrossRefPubMed
4.
Luciani LG, Porpiglia F, Cai T, D’Elia C, Vattovani V, Giusti G, et al. Operative safety and oncologic outcome of laparoscopic radical nephrectomy for renal cell carcinoma >7 cm: a multicenter study of 222 patients. Urology. 2013;81(6):1239–44.CrossRefPubMed
5.
Verhoest G, Couapel JP, Oger E, Rioux-Leclercq N, Pignot G, Patard JJ, et al. Safety and feasibility of laparoscopic nephrectomy for big tumors (>/= 10 cm): a retrospective multicentric study. Clin Genitourin Cancer. 2016;14(4):e335–40.CrossRefPubMed
6.
O’Neal D, Cohen T, Peterson C, Barr RG. Contrast-enhanced ultrasound-guided radiofrequency ablation of renal tumors. J Kidney Cancer VHL. 2018;5(1):7–14.CrossRefPubMedPubMedCentral
7.
Nazari M, Shiri I, Hajianfar G, Oveisi N, Abdollahi H, Deevband MR, et al. Noninvasive Fuhrman grading of clear cell renal cell carcinoma using computed tomography radiomic features and machine learning. Radiol Med. 2020;125(8):754–62.CrossRefPubMed
8.
Yu Y, Wang W, Xiong Z, Yang Z, Li J, Shen Y, et al. Comparison of perioperative outcomes between laparoscopic and open partial nephrectomy for different complexity renal cell carcinoma based on the R.E.N.A.L. Nephrometry Score. Cancer Manag Res. 2021;13:7455–61.CrossRefPubMedPubMedCentral
9.
Tabourin T, Pinar U, Parra J, Vaessen C, Bensalah CK, Audenet F, et al. Impact of renal cell carcinoma histological variants on recurrence after partial nephrectomy: a multi-institutional, prospective study (UROCCR study 82). Ann Surg Oncol. 2022;29(11):7218–28.CrossRefPubMed
10.
Li HB, Han QJ, Li ZJ, Zheng PY, Xu P, Shi ZG, et al. Characters of renal tumor combined with renal vascular abnormality and surgical process experience. J Clin Urol (China). 2018;33(05):401–3+406.
11.
Bai S, Wen N, Wu B. The research on renal blood vessel vairation in patient with renal cell carcinoma. Mod Oncol. 2009;17(08):1523–6.
12.
Satyapal KS, Haffejee AA, Singh B, Ramsaroop L, Robbs JV, Kalideen JM. Additional renal arteries: incidence and morphometry. Surg Radiol Anat. 2001;23(1):33–8.CrossRefPubMed
13.
Gulas E, Wysiadecki G, Cecot T, Majos A, Stefanczyk L, Topol M, et al. Accessory (multiple) renal arteries - differences in frequency according to population, visualizing techniques and stage of morphological development. Vascular. 2016;24(5):531–7.CrossRefPubMed
14.
Tao XF, Zhu JQ, Wu YW, Tang GY, Shi YZ, Zhang L, et al. Dual-energy computed tomography angiography for evaluating the renal vascular variants. Chin Med J (Engl). 2013;126(4):650–4.PubMed
15.
Natsis K, Paraskevas G, Panagouli E, Tsaraklis A, Lolis E, Piagkou M, et al. A morphometric study of multiple renal arteries in Greek population and a systematic review. Rom J Morphol Embryol. 2014;55(3 Suppl):1111–22.PubMed
16.
Saldarriaga B, Perez AF, Ballesteros LE. A direct anatomical study of additional renal arteries in a Colombian mestizo population. Folia Morphol (Warsz). 2008;67(2):129–34.PubMed
17.
Khor LY, Dhakal HP, Jia X, Reynolds JP, McKenney JK, Rini BI, et al. Tumor necrosis adds prognostically significant information to grade in clear cell renal cell carcinoma: a study of 842 consecutive cases from a single institution. Am J Surg Pathol. 2016;40(9):1224–31.CrossRefPubMed
18.
Oh S, Sung DJ, Yang KS, Sim KC, Han NY, Park BJ, et al. Correlation of CT imaging features and tumor size with Fuhrman grade of clear cell renal cell carcinoma. Acta Radiol. 2017;58(3):376–84.CrossRefPubMed
19.
Zhang X, Wang Y, Yang L, Li T, Wu J, Chang R, et al. Delayed enhancement of the peritumoural cortex in clear cell renal cell carcinoma: correlation with Fuhrman grade. Clin Radiol. 2018;73(11):982.e1-e7.CrossRefPubMed
20.
Wei SP, Xu CL, Zhang Q, Zhang QR, Zhao YE, Huang PF, et al. Contrast-enhanced ultrasound for differentiating benign from malignant solid small renal masses: comparison with contrast-enhanced CT. Abdom Radiol (NY). 2017;42(8):2135–45.CrossRefPubMed
21.
Zhu Y, Wang HK, Zhang HL, Yao XD, Zhang SL, Dai B, et al. Visceral obesity and risk of high grade disease in clinical t1a renal cell carcinoma. J Urol. 2013;189(2):447–53.CrossRefPubMed
22.
Hu Z, Wu J, Lai S, Xu Y, Zhan J, Li R, et al. Clear cell renal cell carcinoma: the value of sex-specific abdominal visceral fat measured on CT for prediction of Fuhrman nuclear grade. Eur Radiol. 2020;30(7):3977–86.CrossRefPubMed
23.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–78.CrossRefPubMed
24.
25.
Wang F, Xu Y. Body mass index and risk of renal cell cancer: a dose-response meta-analysis of published cohort studies. Int J Cancer. 2014;135(7):1673–86.CrossRefPubMed
26.
Parker AS, Lohse CM, Cheville JC, Thiel DD, Leibovich BC, Blute ML. Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma. Urology. 2006;68(4):741–6.CrossRefPubMed
27.
Sequeira-Lopez ML, Lin EE, Li M, Hu Y, Sigmund CD, Gomez RA. The earliest metanephric arteriolar progenitors and their role in kidney vascular development. Am J Physiol Regul Integr Comp Physiol. 2015;308(2):R138–49.CrossRefPubMed
Metadata
Title
Characterization of renal artery variation in patients with clear cell renal cell carcinoma and the predictive value of accessory renal artery in pathological grading of renal cell carcinoma: a retrospective and observational study
Authors
Dingyang Lv
Huiyu Zhou
Fan Cui
Jie Wen
Weibing Shuang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2023
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-023-10756-y

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