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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 9/2010

01-09-2010 | Breast Oncology

Ki-67 and Bcl-2 Antigen Expression in Adenomatous Colorectal Polyps from Women with Breast Cancer

Authors: Edílson Carvalho de Sousa-Júnior, MD, Airlane Pereira Alencar, PhD, Benedito Borges da Silva, MD, PhD

Published in: Annals of Surgical Oncology | Issue 9/2010

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Abstract

Background

The aim of this study was to evaluate Ki-67 and Bcl-2 antigen expression in colorectal polyps from women with breast cancer.

Methods

A randomized, controlled study was carried out in 35 women, either with or without breast cancer, who had adenomatous colorectal polyps. The patients were divided into two groups: group A (without breast cancer; control group; n = 17) and group B (with breast cancer; study group; n = 18). Immunohistochemistry was performed on the colorectal polyps to evaluate Ki-67 and Bcl-2 antigen expression. Student’s t-test and the χ2 test were used for the statistical analysis of Ki-67 and Bcl-2 expression, respectively. Statistical significance was established as P < 0.05.

Results

The mean percentage of Ki-67-stained nuclei in groups A and B was 36.25 ± 2.31 and 59.44 ± 3.34 (± SEM), respectively (P < 0.0001), while the percentage of cases with cells expressing Bcl-2 in groups A and B was 23.5 and 77.8%, respectively (P < 0.001).

Conclusions

In the present study, there was greater proliferative activity and greater expression of the antiapoptotic protein Bcl-2 in the colorectal polyps of women with breast cancer.
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Metadata
Title
Ki-67 and Bcl-2 Antigen Expression in Adenomatous Colorectal Polyps from Women with Breast Cancer
Authors
Edílson Carvalho de Sousa-Júnior, MD
Airlane Pereira Alencar, PhD
Benedito Borges da Silva, MD, PhD
Publication date
01-09-2010
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 9/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-0968-5

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