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Graefe's Archive for Clinical and Experimental Ophthalmology

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07-03-2023 | Keratoplasty | Review Article

Use of corneal cross-linking beyond keratoconus: a systemic literature review

Authors: Richard P. C. Manns, Asaf Achiron, Boris Knyazer, Omar Elhaddad, Kieran Darcy, Tal Yahalomi, Derek Tole, Venkata S. Avadhanam

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2023

Abstract

Purpose

The success of corneal collagen cross-linking in altering keratoconus’ clinical course has driven a search for further uses of this procedure. This literature review aims to analyze the scientific evidence available for the benefit of cross-linking in the management of ophthalmic diseases other than progressive keratoconus or ectasia induced by corneal refractive procedures.

Methods

A systemic literature review.

Results

We reviewed 97 studies. We found that collagen cross-linking can limit the progression of several other corneal ectasias, thus reducing and limiting the need for keratoplasty. Collagen cross-linking also can reduce the refractive power of the cornea and can be considered for a moderate degree of bacterial keratitis or when the organism is unidentified, which is refractive to antibiotics alone. However, the comparative rarity of these procedures has limited the extent of evidence. In fungal, Acanthamoeba, and herpes virus keratitis, the evidence is inconclusive of the safety and efficacy of cross-linking.

Conclusion

Current clinical data is limited, and laboratory data has not fully correlated with published clinical data.

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Title: Use of corneal cross-linking beyond keratoconus: a systemic literature review
Authors: Richard P. C. Manns
Asaf Achiron
Boris Knyazer
Omar Elhaddad
Kieran Darcy
Tal Yahalomi
Derek Tole
Venkata S. Avadhanam
Publication date: 07-03-2023
Publisher: Springer Berlin Heidelberg
Keyword: Keratoplasty
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2023
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-023-05994-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Use of corneal cross-linking beyond keratoconus: a systemic literature review

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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