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Graefe's Archive for Clinical and Experimental Ophthalmology

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07-04-2022 | Keratoplasty | Cornea

Outcomes of deep anterior lamellar keratoplasty and penetrating keratoplasty in keratoconic eyes with and without previous hydrops

Authors: Alexander Händel, Jan Niklas Lüke, Sebastian Siebelmann, Jeremy Franklin, Sigrid Roters, Mario Matthaei, Björn O. Bachmann, Claus Cursiefen, Deniz Hos

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2022

Abstract

Purpose

The study aims to compare outcomes after deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) in keratoconic eyes with or without previous hydrops.

Methods

Retrospective analysis of 211 eyes who received PK (group 1, n = 74 [history of hydrops: n = 33]) or DALK (group 2, n = 137 [history of hydrops: n = 9]) from 2012 to 2019 at the Department of Ophthalmology, University of Cologne, Germany. Analysis included best spectacle-corrected visual acuity (BSCVA), complications, immune reactions, graft survival and keratometry, and subgroup analyses for subjects with or without previous hydrops.

Results

Follow-up was 34.0 ± 23.6 months in group 1 and 30.7 ± 22.5 months in group 2. No significant difference was found in the course of BSCVA between groups 1 and 2 (p = 0.182) and in postoperative BSCVA between eyes with and without previous hydrops, regardless of the surgical method (p = 0.768). Endothelial immune reactions occurred exclusively in group 1 and did not occur more frequently in eyes with previous hydrops (p = 0.377). A higher risk of complications for eyes with previous hydrops was observed (p = 0.022). There was no difference in astigmatism and maximum keratometry (K_max) preoperatively and postoperatively between eyes with and without history of hydrops.

Conclusion

The prognosis for visual outcome after keratoplasty including visual acuity, astigmatism, and K_max for keratoconic eyes with previous hydrops is as good as for keratoconic eyes without previous hydrops, irrespective of the surgical method. However, eyes after hydrops seem to have an increased risk of complications.

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Title: Outcomes of deep anterior lamellar keratoplasty and penetrating keratoplasty in keratoconic eyes with and without previous hydrops
Authors: Alexander Händel
Jan Niklas Lüke
Sebastian Siebelmann
Jeremy Franklin
Sigrid Roters
Mario Matthaei
Björn O. Bachmann
Claus Cursiefen
Deniz Hos
Publication date: 07-04-2022
Publisher: Springer Berlin Heidelberg
Keyword: Keratoplasty
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2022
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-022-05643-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Outcomes of deep anterior lamellar keratoplasty and penetrating keratoplasty in keratoconic eyes with and without previous hydrops

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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