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01-05-2019 | Keratoplasty | Clinical Investigation

Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy

Authors: Takashi Ono, Takuya Iwasaki, Chie Yukawa, Yosai Mori, Ryohei Nejima, Tadatoshi Tokunaga, Shiro Amano, Kazunori Miyata

Published in: Japanese Journal of Ophthalmology | Issue 3/2019

Abstract

Purpose

To examine the effects of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy (BK).

Study design

Retrospective case series

Methods

Consecutive patients with BK who did not wish to receive corneal transplantation and were treated with 0.1% betamethasone eyedrops were included. Patients with BK treated with 5% sodium chloride (hypertonic saline) eyedrops served as controls. Central corneal thickness (CCT), best-corrected visual acuity (BCVA), intraocular pressure (IOP), BK etiology, and clinical courses from medical records were retrospectively reviewed. We compared the two groups for differences in CCT, BCVA and IOP before treatment and 2 weeks, 1 month, and 3 months after treatment.

Results

Eighteen eyes of 18 patients who were treated with betamethasone and 18 eyes of 18 patients who were treated with hypertonic saline were included. There was no significant difference in CCT between the two groups before treatment. The reduction of CCT in the betamethasone group was significantly larger than in the hypertonic saline group at 2 weeks (p = 0.002), 1 month (p = 0.02), and 3 months (p = 0.001) after treatment. Complications such as infectious keratitis and IOP rise did not occur during the observation period.

Conclusions

Topical steroid instillation reduced central corneal thickness in eyes with BK.

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Title: Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy
Authors: Takashi Ono
Takuya Iwasaki
Chie Yukawa
Yosai Mori
Ryohei Nejima
Tadatoshi Tokunaga
Shiro Amano
Kazunori Miyata
Publication date: 01-05-2019
Publisher: Springer Japan
Keyword: Keratoplasty
Published in: Japanese Journal of Ophthalmology / Issue 3/2019
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-019-00658-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy

Abstract

Purpose

Study design

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Study design

Methods

Results

Conclusions

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