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European Archives of Psychiatry and Clinical Neuroscience

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01-12-2018 | Short Communication

Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress

Authors: Ji-chun Zhang, Wei Yao, Chao Dong, Mei Han, Yukihiko Shirayama, Kenji Hashimoto

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 8/2018

Abstract

The transcription factor Keap1–Nrf2 signaling plays a key role in the oxidative stress which is involved in psychiatric disorders. In the learned helplessness (LH) paradigm, protein levels of Keap1 and Nrf2 in the prefrontal cortex and dentate gyrus of hippocampus from LH (susceptible) rats were lower than control and non-LH (resilience) rats. Furthermore, protein expressions of Keap1 and Nrf2 in the parietal cortex from major depressive disorder, schizophrenia, and bipolar disorder were lower than controls. These results suggest that Keap1–Nrf2 signaling might contribute to stress resilience which plays a key role in the pathophysiology of psychiatric disorders.

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Title: Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress
Authors: Ji-chun Zhang
Wei Yao
Chao Dong
Mei Han
Yukihiko Shirayama
Kenji Hashimoto
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 8/2018
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-017-0848-0

At a glance: The STEP trials

Springer Medicine

Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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