Hormones OnlineFirst articles

15-05-2024 | Review Article

The interlink between thyroid autoimmunity and type 1 diabetes and the impact on male and female fertility

The aim of this review is to discuss the several interconnections between thyroid autoimmunity and type 1 diabetes in terms of epidemiology, immunoserology, genetic predisposition, and pathogenic mechanisms. We will also analyze the impact of …

Authors:: Sanja Medenica, Vukasin Stojanovic, Umberto Capece, Rossella Mazzilli, Milica Markovic, Virginia Zamponi, Tanja Vojinovic, Silvia Migliaccio, Giuseppe Defeudis, Francesca Cinti

Open Access 14-05-2024 | Glucocorticoid | Original Article

Corticotropin-releasing hormone deficiency results in impaired analgesic response during CFA-induced inflammation

Inflammatory diseases, such as rheumatoid arthritis, are characterized by an intense sensation of pain. Until now, the mechanisms involved in pain response were attributed solely to actions of the nervous system. However, several studies have …

Authors:: Efthymia Karagianni, Olga Rassouli, Smaragda Poulaki, Eirini Dermitzaki, George Liapakis, Andrew N. Margioris, Maria Venihaki

22-04-2024 | Original Article

Indications of younger age at menarche in Greek adolescents but with no relation to body mass index

Worldwide, the timing of female puberty has attracted considerable interest among professionals over time. Excess adipose tissue in childhood is considered a determinant of sexual maturation in girls and, thus, may affect the process of growth and …

Authors:: Anastasia Papageorgiou, Evangelia Charmandari, Vasiliki Efthymiou, Dimitrios Vlachakis, Flora Bacopoulou

Open Access 19-04-2024 | Endometriosis | Original Article

The effect of GnRH-a on the angiogenesis of endometriosis

Endometriosis is a chronic benign gynecological disease that is characterized by the presence of endometriotic tissue outside the uterine cavity [ 1 ]. It is an estrogen-dependent inflammatory disease that affects up to 5 to 10% of …

Authors:: Theodoros Filindris, Efthymia Papakonstantinou, Maria Keramida, Eleftherios Panteris, Sotiris Kalogeropoulos, Neoklis Georgopoulos, Fuminori Taniguchi, George Adonakis, Tasuku Harada, Apostolos Kaponis

18-04-2024 | Hyperglycemia | Teaching Case Presentations

Illness stress-induced transient hyperglycemia in a patient with a novel YIPF5 homozygous missense variant: expanding the phenotype

A recently described type of neonatal diabetes mellitus is caused by mutations in the YIPF5 gene and is combined with manifestations from the central nervous system, including developmental delay, epilepsy, and microcephaly. The molecular …

Authors:: Aristeidis Giannakopoulos, Dionisios Chrysis

18-04-2024 | Testosterone | Letter to the Editor

“Female” and “male” hormones in Greek secondary education biology textbooks

Authors:: Anastasia Armeni, Georgios Ampatzidis

18-04-2024 | Acromegaly | Original Article

Evaluation of the relation between subclinical systolic dysfunction defined by four-dimensional speckle-tracking echocardiography and growth differentiation factor-15 levels in patients with acromegaly

Acromegaly is characterized by increased growth hormone (GH) and insulin-like growth factor-1 (IGF-1), which in the majority of cases is induced by a GH-secreting pituitary tumor. Cardiovascular disease is a highly prevalent comorbidity in …

Authors:: Busra Firlatan, Ugur Nadir Karakulak, Vedat Hekimsoy, Burcin Gonul Iremli, Incilay Lay, Deniz Yuce, Selcuk Dagdelen, Giray Kabakci, Tomris Erbas

18-04-2024 | Historical note

Once upon a time in Anatolia: the kings with bulging eyes

The Hittite Empire, formed by the Hittites who settled in central Anatolia at the beginning of the second millennium BC, has left behind rich archeological remains. In this historical review, statues of the Hittite priest-kings, King Idrimi, King …

Author:: Hulya Elbe

16-04-2024 | Thyroid Disease | Teaching Case Presentations

Thyroid dysfunction due to trace element deficiency

Selenium and zinc deficiency led to thyroid dysfunction in a patient who received total parenteral nutrition without trace element supplementation for one and a half months after intestinal resection.

Authors:: Kohei Nagano, Yuma Motomura, Hironori Bando, Masaaki Yamamoto, Keitaro Kanie, Kei Yoshino, Yushi Hirota, Tomoko Yamada, Michiko Takahashi, Hidenori Fukuoka, Wataru Ogawa

16-04-2024 | Estradiol | Original Article

Synergistic neuroprotective action of prolactin and 17β-estradiol on kainic acid-induced hippocampal injury and long-term memory deficit in ovariectomized rats

The neuroprotective actions of the ovarian hormone 17β-estradiol (E2), also synthesized in the brain, against diverse injuries have been consistently confirmed in a variety of models, including β-amyloid toxicity, kainic acid (KA), and quinolinic …

Authors:: Karen De la Torre, Marco Antonio Cerbón, Gladys Molina-Salinas, José Eduardo Suárez-Santiago, Jean-Pascal Morin, Gabriel Roldán-Roldán, Ofir Picazo

15-04-2024 | Endocrinology | Review Article Free for a limited time

Highlights from EndoBridge 2023

Everything you need to know from EndoBridge 2023. Find out the latest developments across all aspects of endocrinology and metabolism, and learn about the clinical approaches to common endocrine issues.

Authors:: Bulent Okan Yildiz, Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski, Luca Busetto, Ozlem Celik, Ghada El-Hajj Fuleihan, Dimitrios G. Goulis, Gary D. Hammer, Megan R. Haymart, Gregory Kaltsas, Jennifer R. Law, Amanda Yuan Ling Lim, Anton Luger, Djuro Macut, Barbara McGowan, Michael McClung, Alexander Dimitri Miras, Mary Elizabeth Patti, Robin P. Peeters, Duarte Pignatelli, Hamayle Saeed, Jennifer Sipos, Constantine A. Stratakis, Marina Tsoli, A. J. van der Lely, Selma F. Witchel, Dilek Yazici

Open Access 15-04-2024 | Neuroendocrine Tumor | Rapid Communication

When rare diseases crisscross within the same patient: von Hippel-Lindau and type 1 gastric neuroendocrine tumor

Von-Hippel-Lindau (VHL) is a genetic multisystem disorder characterized by visceral cysts and benign and malignant tumors in various organs. Herein, we present the case of a 23-year-old woman with VHL presenting with multiple gastric …

Authors:: Krystallenia I. Alexandraki, Ariadni Spyroglou, Paraskevi Xekouki, Konstantinos I. Bramis, Georgios Kyriakopoulos, Konstantinos Barkas, Ioannis S. Papanikolaou, George Mastorakos, Manousos Konstadoulakis

Open Access 12-04-2024 | Hypoglycemia | Original Article

Evaluation of the possible impact of the fear of hypoglycemia on diabetes management in children and adolescents with type 1 diabetes mellitus and their parents: a cross-sectional study

Hypoglycemia constitutes the commonest acute complication of type 1 diabetes mellitus (T1DM) [ 1 ]. Aggressive HbA1c goals may increase the frequency of hypoglycemia, which represents a major limiting factor in the glycemic control of T1DM [ 2 ].

Authors:: Ourania Andreopoulou, Eirini Kostopoulou, Eleni Kotanidou, Sophia Daskalaki, Angeliki Vakka, Assimina Galli-Tsinopoulou, Bessie E Spiliotis

06-04-2024 | Hyperthyroidism | Meta-analysis

Association between serum TSH concentration and bone mineral density: an umbrella review

Thyroid hormones are known to stimulate bone turnover in adults by increasing osteoclast activity and bone resorption [ 1 ]. Furthermore, endogenous and exogenous hyperthyroidism are acknowledged risk factors for osteoporosis [ 2 ]. However …

Authors:: Martyna Dziedzic, Michał Bonczar, Patryk Ostrowski, Bartłomiej Stachera, Dawid Plutecki, Monika Buziak-Bereza, Alicja Hubalewska-Dydejczyk, Jerzy Walocha, Mateusz Koziej

02-04-2024 | Original Article

Reference intervals for thyroid function from the fifth to seventh day of life in twin-pregnancy preterm neonates: an 8-year retrospective study

Dysfunction of the hypothalamic-pituitary-thyroid (HPT) axis at birth leads to congenital hypothyroidism (CH), decreasing thyroid hormone (TH) production. When serum free thyroxine (FT4) and free triiodothyronine (FT3) levels are low and …

Authors:: Xin-Ting Zheng, Xin Lin, Mei Ma, Shu-Hua Lai, Chang-Yi Yang

02-04-2024 | Respiratory Microbiota | Original Article

The causal impact of gut microbiota on circulating adipokine concentrations: a two-sample Mendelian randomization study

In recent decades, the global prevalence of obesity and the burden of obesity-related diseases have risen sharply [ 1 ]. Today, more than 650 million people worldwide are obese, this constituting a major global health challenge [ 2 ]. Evidence …

Authors:: Tongxin Zhang, Jingyu Liu, Xiao Liu, Qian Wang, Huawei Zhang

27-03-2024 | Original Article

Clinical prediction model for primary aldosteronism subtyping and special focus on adrenal volumetric assessment

Primary aldosteronism (PA) is the most prevalent cause of secondary hypertension, representing approximately 3.2–12.7% of all hypertensive cases in clinical practice and 17–23% of all cases with resistant hypertension [ 1 – 3 ]. It has been …

Authors:: Tugba Barlas, Erhan Turgut Ilgit, Mehmet Koray Akkan, Emetullah Cindil, Isil Imge Gultekin, Hulya Nur Sodan, Mehmet Muhittin Yalcin, Ethem Turgay Cerit, Sinan Sozen, Mujde Akturk, Fusun Toruner, Ayhan Karakoc, Alev Eroglu Altinova

Open Access 25-03-2024 | Hypospadia | Original Article

Expanding the phenotypic spectrum of LHCGR signal peptide insertion variant: novel clinical and allelic findings causing Leydig cell hypoplasia type II

Luteinizing hormone/choriogonadotropin receptor (LHCGR) is involved in the development and maturation of male sexual organs both prenatally and postnatally [ 25 ]. Sexual differentiation is a critical and complex process which normally drives the …

Authors:: Heba Amin Hassan, Inas Mazen, Aya Elaidy, Alaa K Kamel, Noura R. Eissa, Mona L. Essawi

Open Access 18-03-2024 | Correction

Correction: The neurohypophyseal hormone oxytocin and eating behaviors: a narrative review

Authors:: Michele Iovino, Tullio Messana, Simonetta Marucci, Domenico Triggiani, Vito Angelo Giagulli, Edoardo Guastamacchia, Giuseppina Piazzolla, Giovanni De Pergola, Giuseppe Lisco, Vincenzo Triggiani

Open Access 18-03-2024 | Correction

Correction: Comparison of clinical characteristics of a pediatric cohort with combined pituitary hormone deficiency caused by mutation of the PROP1 gene or of other origins

Authors:: Agata Zygmunt-Górska, Małgorzata Wójcik, Aleksandra Gilis-Januszewska, Anna Starmach, Mirosław Bik-Multanowski, Jerzy B. Starzyk

At a glance: The STEP trials

Springer Medicine