Modern Rheumatology OnlineFirst articles

28-05-2013 | Original Article

Assessment of the Birmingham vasculitis activity score in patients with MPO-ANCA-associated vasculitis: sub-analysis from a study by the Japanese Study Group for MPO-ANCA-associated vasculitis

Among the small-vessel vasculitides, microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) are collectively known as the ANCA-associated vasculitides (AAV), because of the …

Authors:: Wako Yumura, Shigeto Kobayashi, Machi Suka, Taichi Hayashi, Satoshi Ito, Hiroko Nagafuchi, Hidehiro Yamada, Shoichi Ozaki

Open Access 17-05-2013 | Original Article

Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study

Tocilizumab (TCZ) treatment frequently achieves remission in patients with rheumatoid arthritis (RA) as measured by the 28-joint disease activity score (DAS28) [ 1 – 12 ]. We have demonstrated in the DREAM study ( Drug free remission/low disease …

Authors:: Norihiro Nishimoto, Koichi Amano, Yasuhiko Hirabayashi, Takahiko Horiuchi, Tomonori Ishii, Mitsuhiro Iwahashi, Masahiro Iwamoto, Hitoshi Kohsaka, Masakazu Kondo, Tsukasa Matsubara, Toshihide Mimura, Hisaaki Miyahara, Shuji Ohta, Yukihiko Saeki, Kazuyoshi Saito, Hajime Sano, Kiyoshi Takasugi, Tsutomu Takeuchi, Shigeto Tohma, Tomomi Tsuru, Yukitaka Ueki, Jiro Yamana, Jun Hashimoto, Takaji Matsutani, Miho Murakami, Nobuhiro Takagi

14-05-2013 | Original Article

Post-marketing surveillance of the safety and effectiveness of tacrolimus in 3,267 Japanese patients with rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by persistent synovitis and structural damage of joints in part through the abnormal activation of immunocompetent cells, including T cells. It has been reported that pathogenesis of RA remains elusive in …

Authors:: Tsutomu Takeuchi, Shinichi Kawai, Kazuhiko Yamamoto, Masayoshi Harigai, Kota Ishida, Nobuyuki Miyasaka

07-05-2013 | Original Article

Discrepancy in bone mineral densities at different skeletal sites in hip osteoarthritis patients

Osteoarthritis (OA) and osteoporosis are two age-related degenerative diseases that are common in middle-aged and older women [ 1 , 2 ]. The generally held opinion is that the incidence of osteoporosis is inversely associated with the incidence of …

Authors:: Kunihiko Okano, Masako Ito, Kiyoshi Aoyagi, Makoto Osaki, Hiroshi Enomoto, Kazumasa Yamaguchi

Open Access 03-05-2013 | Original Article

Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study

Newly licensed medications, especially biological agents, have enabled the attainment of unprecedented outcomes for patients with rheumatoid arthritis (RA) [ 1 – 4 ], and structured patient management aiming to achieve remission is an achievable …

Authors:: Norihiro Nishimoto, Koichi Amano, Yasuhiko Hirabayashi, Takahiko Horiuchi, Tomonori Ishii, Mitsuhiro Iwahashi, Masahiro Iwamoto, Hitoshi Kohsaka, Masakazu Kondo, Tsukasa Matsubara, Toshihide Mimura, Hisaaki Miyahara, Shuji Ohta, Yukihiko Saeki, Kazuyoshi Saito, Hajime Sano, Kiyoshi Takasugi, Tsutomu Takeuchi, Shigeto Tohma, Tomomi Tsuru, Yukitaka Ueki, Jiro Yamana, Jun Hashimoto, Takaji Matsutani, Miho Murakami, Nobuhiro Takagi

30-04-2013 | Original Article

Elevated miR-29a expression is not correlated with disease activity index in PBMCs of patients with ankylosing spondylitis

New bone formation of the vertebral column is pathognomonic for ankylosing spondylitis (AS), while acute and/or chronic changes in the sacroiliac joints are relevant for diagnosis. Mounting evidence indicates that Dkk-1 negative regulation in Wnt …

Authors:: Jinxian Huang, Guoxiang Song, Zhihua Yin, Xiuxia Luo, Zhizhong Ye

27-04-2013 | Letter

The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients

Authors:: Yuri Hatta, Minoru Hasegawa, Takashi Matsushita, Yasuhito Hamaguchi, Manabu Fujimoto, Kazuhiko Takehara

25-04-2013 | Case Report

A novel recessive 15-hydroxyprostaglandin dehydrogenase mutation in a family with primary hypertrophic osteoarthropathy

We present two PHO siblings having a novel homozygous truncating mutation in HPGD. The purpose of the study was to attempt medical treatment, and to find the HPGD mutation causing the disease, in a 22-year old Turkish male and his 23-year old …

Authors:: Eren Erken, Çiğdem Köroğlu, Fatih Yıldız, Hüseyin T. E. Özer, Bozkurt Gülek, Aslıhan Tolun

25-04-2013 | Case Report

A case of Degos disease: demonstration of C5b-9-mediated vascular injury

A 68-year-old Japanese male presented with atrophic erythematous white lesions with peripheral dark reddish rims on his back. Multiple ulcers were detected from his stomach to his large intestine using endoscopy. Although the patient was given …

Authors:: Masayu Umemura, Yusuke Miwa, Ryo Yanai, Sakiko Isojima, Takahiro Tokunaga, Hiroyuki Tsukamoto, Ryo Takahashi, Nobuyuki Yajima, Tsuyoshi Kasama, Nanako Takahashi, Hirohiko Sueki, Sayaka Yamaguchi, Katsuhito Arai, Yoshiaki Takeuchi, Nobuyuki Ohike, Tomoko Norose, Toshiko Yamochi-Onizuka, Masafumi Takimoto

25-04-2013 | Original Article

Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case–control study

Rheumatoid arthritis (RA) is a chronic inflammatory disease with both genetic and environmental factors involved in the etiology [ 1 ]. Kowledge about the genetic contribution is rapidly increasing [ 2 , 3 ] but there is still a lack of data on …

Authors:: Abqariyah Yahya, Camilla Bengtsson, Per Larsson, Chun Lai Too, Amal Nasir Mustafa, Nor Aini Abdullah, Nor Asiah Muhamad, Lars Klareskog, Shahnaz Murad, Lars Alfredsson

25-04-2013 | Rapid Communication

Mycophenolate mofetil therapy for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis

Authors:: Haruka Tsuchiya, Hirotaka Tsuno, Mariko Inoue, Yuko Takahashi, Hiroyuki Yamashita, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori

20-04-2013 | Letter

Antibiotics may be useful in the treatment of SAPHO syndrome

Authors:: Matteo Colina, Francesco Trotta

18-04-2013 | Rapid Communication

A marriage with sarcoidosis

Authors:: Corina Kollert, Reinhard E. Voll, Florian Kollert

13-04-2013 | Rapid Communication

Abatacept management during the perioperative period in patients with rheumatoid arthritis: report on eight orthopaedic procedures

Authors:: Keiichiro Nishida, Yoshihisa Nasu, Kenzo Hashizume, Ryuichi Nakahara, Masatsugu Ozawa, Ryozo Harada, Takahiro Machida, Toshihumi Ozaki

12-04-2013 | Original Article

Validation of the 2010 histopathological classification of ANCA-associated glomerulonephritis in a Japanese single-center cohort

Anti-neutrophil cytoplasmic antibodies (ANCA)-associated diseases are a spectrum of heterogeneous autoimmune diseases characterized by small vessel vasculitis [ 1 ]. Disease descriptions include microscopic polyangiitis, Churg–Strauss syndrome …

Authors:: Masaru Togashi, Atsushi Komatsuda, Mizuho Nara, Ayumi Omokawa, Shin Okuyama, Kenichi Sawada, Hideki Wakui

12-04-2013 | Original Article

Evaluation of Tp-e interval and Tp-e/QT ratio in patients with ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic multi-systemic inflammatory rheumatic disorder mainly affecting the axial skeleton [ 1 ]. In AS patients, there are various cardiovascular system manifestations, including aortic insufficiency due to …

Authors:: Gurkan Acar, Hikmet Yorgun, Mehmet Fatih İnci, Murat Akkoyun, Betul Bakan, Alper Bugra Nacar, Imran Dirnak, Gozde Yildirim Cetin, Orhan Bozoglan

10-04-2013 | Original Article

Prevalence of low back pain as the primary pain site and factors associated with low health-related quality of life in a large Japanese population: a pain-associated cross-sectional epidemiological survey

Low back pain (LBP) is a common [ 1 ], costly [ 2 ], and, at times, disabling [ 3 ] condition that can lead to disability and sick leave from work or school. Pain at this site often fluctuates over time with frequent recurrences or exacerbations [ …

Authors:: Koji Yamada, Ko Matsudaira, Katsushi Takeshita, Hiroyuki Oka, Nobuhiro Hara, Yasuo Takagi

09-04-2013 | Original Article

Frequencies of circulating IL-17-producing CD4+CD161+ T cells and CD4+CD161+ T cells correlate with disease activity in rheumatoid arthritis

Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovial hyperplasia that leads to joint destruction and disability. A variety of innate and adaptive effector cells, including macrophages, mast cells, neutrophils …

Authors:: Jinlin Miao, Jiejie Geng, Kui Zhang, Xueyi Li, Qiang Li, Cuicui Li, Ping Zhu

08-04-2013 | Case Report

Coexistence of two rare genetic disorders: Kartagener syndrome and familial Mediterranean fever

Primary ciliary dyskinesia (PCD) is a rare disease, predominantly inherited as an autosomal recessive, with ciliary dysfunction leading to impaired mucociliary clearance, chronic airway infection and inflammation. Situs inversus totalis occurs in …

Authors:: Deniz Çetin, Beyza Genç Çetin, Taşkın Şentürk, Songül Şahin Çildağ, İkbal Yılmaz Akdam

08-04-2013 | Original Article

Remission in patients with active rheumatoid arthritis by tocilizumab treatment in routine clinical practice: results from 3 years of prospectively registered data

The therapeutic landscape in the management of rheumatoid arthritis (RA) has undergone significant changes over the past decade. Recent consensus is that patients with progressive joint destruction should be treated with biologics for tight …

Authors:: Yasuharu Nakashima, Masakazu Kondo, Takaaki Fukuda, Hiroshi Harada, Takahiko Horiuchi, Takashi Ishinishi, Hiroshi Jojima, Koji Kuroda, Hisaaki Miyahara, Masayuki Maekawa, Hiroaki Nishizaka, Ryuji Nagamine, Hitoshi Nakashima, Takeshi Otsuka, Eisuke Shono, Eiichi Suematsu, Takashi Shimauchi, Tomomi Tsuru, Ken Wada, Shigeru Yoshizawa, Seiji Yoshizawa, Yukihide Iwamoto

Keynote webinar | Spotlight on medication adherence

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