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European Journal of Clinical Microbiology & Infectious Diseases

16-05-2024 | Joint Infection | Brief Report

Dalbavancin as suppressive therapy for implant-related infections: a case series with therapeutic drug monitoring and review of the literature

Authors: Barthelemy Lafon-Desmurs, Benoit Gachet, Benjamin Hennart, Benjamin Valentin, Gabrielle Roosen, Maxime Degrendel, Caroline Loiez, Eric Beltrand, Piervito D’Elia, Henri Migaud, Olivier Robineau, Eric Senneville

Published in: European Journal of Clinical Microbiology & Infectious Diseases

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Abstract

Implant-related infections may need suppressive antibiotic therapy (SAT). We describe a SAT strategy using dalbavancin with therapeutic drug monitoring (TDM). This is a retrospective bicentric study of patients with implant-related infection who received dalbavancin SAT between January 2021 and September 2023. Fifteen patients were included. Median number of injections was 4 (IQR: 2–7). Median time between two reinjections was 57 days (IQR 28–82). Dalbavancin plasma concentrations were above 4 mg/L for 97.9% of dosages (93/95) and above 8 mg/L for 85% (81/95). These results support the use of dalbavancin SAT for implant-related infections.
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Literature
1.
Smeds MR, Duncan AA, Harlander-Locke MP, Lawrence PF, Lyden S, Fatima J et al (2016) Treatment and outcomes of aortic endograft infection. J Vasc Surg févr 63(2):332–340CrossRef
2.
3.
Zhang C, Liu Z, Lin Y, Cai Y, Zhang X, Huang Z et al (2022) Patient-reported outcome on quality of life and pain after revision arthroplasty for periprosthetic joint infection: A cross-sectional study. J Clin Med 11(23):7182CrossRefPubMedPubMedCentral
4.
Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM et al (2013) Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis janv 56(1):e1-25CrossRef
5.
Pouderoux C, Becker A, Goutelle S, Lustig S, Triffault-Fillit C, Daoud F et al (2019) Subcutaneous suppressive antibiotic therapy for bone and joint infections: safety and outcome in a cohort of 10 patients. J Antimicrob Chemother 74(7):2060–4CrossRefPubMed
6.
Rottier W, Seidelman J, Wouthuyzen-Bakker M (2023) Antimicrobial treatment of patients with a periprosthetic joint infection: basic principles. Arthroplasty 5(1):10CrossRefPubMedPubMedCentral
7.
Antonello RM, D’Oria M, Cavallaro M, Dore F, Cova MA, Ricciardi MC et al (2019) Management of abdominal aortic prosthetic graft and endograft infections. A multidisciplinary update. J Infect Chemother 25(9):669–80CrossRefPubMed
8.
9.
Escudero-Sanchez R, Senneville E, Digumber M, Soriano A, Del Toro MD, Bahamonde A et al (2020) Suppressive antibiotic therapy in prosthetic joint infections: a multicentre cohort study. Clin Microbiol Infect avr 26(4):499–505CrossRef
10.
Molina KC, Miller MA, Mueller SW, Van Matre ET, Krsak M, Kiser TH (2022) Clinical pharmacokinetics and pharmacodynamics of Dalbavancin. Clin Pharmacokinet 61(3):363–74CrossRefPubMed
11.
Tobudic S, Forstner C, Burgmann H, Lagler H, Steininger C, Traby L et al (2019) Real-world experience with dalbavancin therapy in gram-positive skin and soft tissue infection, bone and joint infection. Infection 47(6):1013–20CrossRefPubMed
12.
13.
Matt M, Duran C, Courjon J, Lotte R, Moing VL, Monnin B et al (2021) Dalbavancin treatment for prosthetic joint infections in real-life: a national cohort study and literature review. J Glob Antimicrob Resist juin 25:341–345CrossRef
14.
Hitzenbichler F, Mohr A, Camboni D, Simon M, Salzberger B, Hanses F (2021) Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source-a series of four cases. Infection févr 49(1):181–186CrossRef
15.
Gatti M, Viale P, Cojutti PG, Zamparini E, De Paolis M, Giannella M et al (2023) A descriptive case series of the relationship between maintenance of conservative PK/PD efficacy thresholds of dalbavancin over time and clinical outcome in long-term treatment of staphylococcal osteoarticular infections. Int J Antimicrob Agents mai 61(5):106773CrossRef
16.
Cojutti PG, Rinaldi M, Gatti M, Tedeschi S, Viale P, Pea F (2021) Usefulness of therapeutic drug monitoring in estimating the duration of dalbavancin optimal target attainment in staphylococcal osteoarticular infections: a proof-of-concept. Int J Antimicrob Agents 58(5):106445CrossRefPubMed
17.
Simon S, Frank BJH, Hartmann S, Hinterhuber L, Reitsamer M, Aichmair A et al (2022) Dalbavancin in Gram-positive periprosthetic joint infections. J Antimicrob Chemother 77(8):2274–7CrossRefPubMed
18.
Dinh A, Duran C, Pavese P, Khatchatourian L, Monnin B, Bleibtreu A et al (2019) French national cohort of first use of dalbavancin: A high proportion of off-label use. Int J Antimicrob Agents 54(5):668–72CrossRefPubMed
19.
Núñez-Núñez M, Casas-Hidalgo I, García-Fumero R, Vallejo-Rodríguez I, Anguita-Santos F, Hernández-Quero J et al (2020) Dalbavancin is a novel antimicrobial against Gram-positive pathogens: clinical experience beyond labelled indications. Eur J Hosp Pharm 27(5):310–312CrossRefPubMed
20.
Spaziante M, Franchi C, Taliani G, D’Avolio A, Pietropaolo V, Biliotti E et al (2019) Serum bactericidal activity levels monitor to guide Intravenous Dalbavancin Chronic suppressive therapy of inoperable staphylococcal prosthetic Valve Endocarditis: A case report. Open Forum Infect Dis 6(11):ofz427CrossRefPubMedPubMedCentral
21.
Howard-Anderson J, Pouch SM, Sexton ME, Mehta AK, Smith AL, Lyon GM et al (2019) Left ventricular assist device infections and the potential role for Dalbavancin: A case report. Open Forum Infect Dis 6(9):ofz235CrossRefPubMedPubMedCentral
22.
Barbero Allende JM, García Sánchez M, CulebrasLópez AM, Agudo AR (2021) Suppressive antibiotic treatment with dalbavancin. A case report. Rev Esp Quimioter 34(2):151–3CrossRefPubMed
23.
Matesanz M, Poza A, Iñurrieta A, Fernández-Diaz E, Arroyo M, Domínguez I et al (2021) Dalbavancin was effective and safe after one year of treatment in a complicated osteoarticular infection caused by methicillin-resistant Staphylococcus aureus. Rev Esp Quimioter août 34(4):396–399CrossRef
24.
Ruiz-Sancho A, Núñez-Núñez M, Castelo-Corral L, Martínez-Marcos FJ, Lois-Martínez N, Abdul-Aziz MH et al (2023) Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety. Front Pharmacol 14:1185602CrossRefPubMedPubMedCentral
25.
Lepak A, Marchillo K, VanHecker J, Andes D (2015) Impact of glycopeptide resistance in staphylococcus aureus on the Dalbavancin In Vivo pharmacodynamic target. Antimicrob Agents Chemother déc 59(12):7833–7836CrossRef
26.
Arrieta-Loitegui M, Caro-Teller JM, Ortiz-Pérez S, López-Medrano F, San Juan-Garrido R, Ferrari-Piquero JM (2022) Effectiveness, safety and cost analysis of dalbavancin in clinical practice. Eur J Hosp Pharm janv 29(1):55–58CrossRef
27.
Zhang R, Polenakovik H, Barreras Beltran IA, Waalkes A, Salipante SJ, Xu L et al (2022) Emergence of Dalbavancin, Vancomycin, and Daptomycin Nonsusceptible Staphylococcus aureus in a patient treated with Dalbavancin: Case report and isolate characterization. Clin Infect Dis 75(9):1641–4CrossRefPubMedPubMedCentral
28.
Werth BJ, Jain R, Hahn A, Cummings L, Weaver T, Waalkes A et al (2018) Emergence of dalbavancin non-susceptible, vancomycin-intermediate Staphylococcus aureus (VISA) after treatment of MRSA central line-associated bloodstream infection with a dalbavancin- and vancomycin-containing regimen. Clin Microbiol Infect avr 24(4):429.e1-429.e5CrossRef
29.
Kussmann M, Karer M, Obermueller M, Schmidt K, Barousch W, Moser D et al (2018) Emergence of a dalbavancin induced glycopeptide/lipoglycopeptide non-susceptible Staphylococcus aureus during treatment of a cardiac device-related endocarditis. Emerg Microbes Infect 7:202CrossRefPubMedPubMedCentral
Metadata
Title
Dalbavancin as suppressive therapy for implant-related infections: a case series with therapeutic drug monitoring and review of the literature
Authors
Barthelemy Lafon-Desmurs
Benoit Gachet
Benjamin Hennart
Benjamin Valentin
Gabrielle Roosen
Maxime Degrendel
Caroline Loiez
Eric Beltrand
Piervito D’Elia
Henri Migaud
Olivier Robineau
Eric Senneville
Publication date
16-05-2024
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Clinical Microbiology & Infectious Diseases
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-024-04849-0
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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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