Ischemic Stroke in a Patient with Hetrozygous Factor V Leiden Mutation: An Uncommon Association

Excerpt

Thrombosis is a major cause of morbidity and mortality in a wide range of arterial and venous diseases. It is a multicausal disease involving genetic and acquired risk factors like immobility, malignancy, pregnancy, oral contraceptive use and autoimmune disease [1]. The genetically determined increased likelihood of thrombosis is called thrombophilia. It is commonly due to activated protein C (APC) resistance due to factor V leiden mutation and prothrombin polymorphism. Other less common inherited causes are deficiencies of the protein C, protein S and anti thrombin, hyperhomocysteinemia and increased levels of factor VIII [2, 3]. Venous thrombosis or thromboembolism is most common manifestation of thrombophilia. Arterial thrombosis is present in only minority of cases especially with associated acquired risk factors [4]. We report a patient who developed ischemic stroke due to factor V leiden mutation which is quite rare first presentation. …