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Published in: European Journal of Nuclear Medicine and Molecular Imaging 3/2005

01-03-2005 | Controversies–Against

Is whole-body FDG-PET valuable for health screening?

Authors: Matthias Weckesser, Otmar Schober

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2005

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Excerpt

The idea of using imaging for whole-body cancer screening is alluring. Every nuclear medicine physician working with 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) has observed patients with malignancies unrelated to the referral diagnosis. In a series of such clinically unexpected results, Agress and Cooper showed that ‘incidental’ does not mean ‘negligible’; considerable pathology, especially in the colon, may be detected [1]. These observations suggest the use of FDG-PET for health screening. The justification for such an approach, however, is far from clear, and many prerequisites will have to be met before FDG-PET can be recommended for this purpose. …
Literature
1.
go back to reference Agress H Jr, Cooper BZ. Detection of clinically unexpected malignant and premalignant tumors with whole-body FDG PET: histopathologic comparison. Radiology 2004;230:417–22. Agress H Jr, Cooper BZ. Detection of clinically unexpected malignant and premalignant tumors with whole-body FDG PET: histopathologic comparison. Radiology 2004;230:417–22.
3.
go back to reference Bayes T. An essay toward solving a problem in the doctrine of chances. Philos Trans R Soc Lond 1763;53:370–418. Bayes T. An essay toward solving a problem in the doctrine of chances. Philos Trans R Soc Lond 1763;53:370–418.
4.
go back to reference Drenth JP, Nagengast FM, Oyen WJ. Evaluation of (pre-)malignant colonic abnormalities: endoscopic validation of FDG-PET findings. Eur J Nucl Med 2001;28:1766–9.CrossRef Drenth JP, Nagengast FM, Oyen WJ. Evaluation of (pre-)malignant colonic abnormalities: endoscopic validation of FDG-PET findings. Eur J Nucl Med 2001;28:1766–9.CrossRef
5.
go back to reference Yasuda S, Fujii H, Nakahara T, Nishiumi N, Takahashi W, Ide M, et al. 18F-FDG PET detection of colonic adenomas. J Nucl Med 2001;42:989–92. Yasuda S, Fujii H, Nakahara T, Nishiumi N, Takahashi W, Ide M, et al. 18F-FDG PET detection of colonic adenomas. J Nucl Med 2001;42:989–92.
6.
go back to reference Patz EF Jr, Goodman PC, Bepler G. Screening for lung cancer. N Engl J Med 2000;30(343):1627–33.CrossRef Patz EF Jr, Goodman PC, Bepler G. Screening for lung cancer. N Engl J Med 2000;30(343):1627–33.CrossRef
7.
go back to reference Chen YK, Kao CH, Liao AC, Shen YY, Su CT. Colorectal cancer screening in asymptomatic adults: the role of FDG PET scan. Anticancer Res 2003;23:4357–61. Chen YK, Kao CH, Liao AC, Shen YY, Su CT. Colorectal cancer screening in asymptomatic adults: the role of FDG PET scan. Anticancer Res 2003;23:4357–61.
8.
go back to reference Shen YY, Su CT, Chen GJ, Chen YK, Liao AC, Tsai FS. The value of 18F-fluorodeoxyglucose positron emission tomography with the additional help of tumor markers in cancer screening. Neoplasma 2003;50:217–21. Shen YY, Su CT, Chen GJ, Chen YK, Liao AC, Tsai FS. The value of 18F-fluorodeoxyglucose positron emission tomography with the additional help of tumor markers in cancer screening. Neoplasma 2003;50:217–21.
9.
go back to reference Yasuda S, Ide M, Fujii H, Nakahara T, Mochizuki Y, Takahashi W, et al. Application of positron emission tomography imaging to cancer screening. Br J Cancer 2000;83:1607–11.CrossRef Yasuda S, Ide M, Fujii H, Nakahara T, Mochizuki Y, Takahashi W, et al. Application of positron emission tomography imaging to cancer screening. Br J Cancer 2000;83:1607–11.CrossRef
10.
go back to reference Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study. Circulation 2002;105:310–5.CrossRefPubMed Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study. Circulation 2002;105:310–5.CrossRefPubMed
11.
go back to reference Smith JA, Andreopoulou E. An overview of the status of imaging screening technology for breast cancer. Ann Oncol 2004;15:I18–26.CrossRef Smith JA, Andreopoulou E. An overview of the status of imaging screening technology for breast cancer. Ann Oncol 2004;15:I18–26.CrossRef
12.
go back to reference Ell PJ. News and views. Eur J Nucl Med Mol Imaging 2005;31:127–38. Ell PJ. News and views. Eur J Nucl Med Mol Imaging 2005;31:127–38.
13.
go back to reference Deloar HM, Fujiwara T, Shidahara M, Nakamura T, Watabe H, Narita Y, et al. Estimation of absorbed dose for 2-[F-18]fluoro-2-deoxy-d-glucose using whole-body positron emission tomography and magnetic resonance imaging. Eur J Nucl Med 1998;25:565–74.CrossRef Deloar HM, Fujiwara T, Shidahara M, Nakamura T, Watabe H, Narita Y, et al. Estimation of absorbed dose for 2-[F-18]fluoro-2-deoxy-d-glucose using whole-body positron emission tomography and magnetic resonance imaging. Eur J Nucl Med 1998;25:565–74.CrossRef
14.
go back to reference International Commission on Radiological Protection, Report No. 60 (1991) Recommendations of the International Commission on Radiological Protection. International Commission on Radiological Protection, Report No. 60 (1991) Recommendations of the International Commission on Radiological Protection.
15.
go back to reference Pastorino U, Bellomi M, Landoni C, De Fiori E, Arnaldi P, Picchio M, et al. Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results. Lancet 2003;362:593–97.CrossRefPubMed Pastorino U, Bellomi M, Landoni C, De Fiori E, Arnaldi P, Picchio M, et al. Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results. Lancet 2003;362:593–97.CrossRefPubMed
Metadata
Title
Is whole-body FDG-PET valuable for health screening?
Authors
Matthias Weckesser
Otmar Schober
Publication date
01-03-2005
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2005
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-005-1775-2

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