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European Archives of Oto-Rhino-Laryngology

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01-01-2019 | Otology

Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?

Authors: Selda Kargin Kaytez, Ali Kavuzlu, Nihat Yumusak, Ramazan Oçal, Ozlem Akkoca

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2019

Abstract

Objectives

In this study, our aim was to identify the possible effects of montelukast sodium (ML) on the prevention of experimentally induced myringosclerosis.

Materials and methods

Twenty-eight female Wistar albino rats were used and they were divided into four groups randomly. Tympanic membranes (TM) of all animals were perforated and then group 1 received no treatment (control group), group 2 was treated with a topical saline solution, group 3 received topically ML and group 4 received orally ML. On the 15th day, all animals were euthanized. Tympanic membranes were evaluated otomicroscopically and histopathologically.

Results

The histopathological findings, compared against a control and saline groups, showed the topically and orally ML groups had statistically significant differences of degree of myringosclerosis (p < 0.002) and median thickness of the TMs (p < 0.001). Suppression of inflammation was statistically significant only in the oral ML treatment group (p < 0.002).

Conclusion

Oral and topically administration of ML reduced myringosclerosis formation in myringotomies rats.

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Title: Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?
Authors: Selda Kargin Kaytez
Ali Kavuzlu
Nihat Yumusak
Ramazan Oçal
Ozlem Akkoca
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2019
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-5181-3

At a glance: The STEP trials

Springer Medicine

Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?

Abstract

Objectives

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

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