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01-11-2006 | Hepatobiliary-Pancreas

Is microbubble-enhanced ultrasonography sufficient for assessment of response to percutaneous treatment in patients with early hepatocellular carcinoma?

Authors: R. Vilana, L. Bianchi, M. Varela, C. Nicolau, M. Sánchez, C. Ayuso, M. García, M. Sala, J. M. Llovet, J. Bruix, C. Bru, BCLC Group

Published in: European Radiology | Issue 11/2006

Abstract

The objective of this study was to assess the efficacy of contrast-enhanced ultrasonography (CEUS) with SonoVue ^R to evaluate the response to percutaneous treatment (ethanol injection/radiofrequency) of hepatocellular carcinoma in comparison with spiral computed tomography (CT) immediately and 1 month after treatment. Forty-one consecutive cirrhotic patients with early stage tumor (not suitable for resection) were included. Spiral CT and CEUS were performed in all patients before treatment, in the following 24 h, and 1 month later. The results of each examination were compared with the 1-month spiral CT, considered the gold standard technique. The 24-h CEUS and the 24-h spiral CT sensitivity to detect residual disease were 27% and 20%, respectively. The 24-h CEUS and the 24-h spiral CT positive predictive value of persistent vascularization detection were 75% and 66%, respectively. The 1-month CEUS detected partial responses in ten out of 11 cases (91% sensitivity, 97% specificity, 95% accuracy). Spiral CT and CEUS performed in the 24 h following treatment are slightly useful to evaluate therapeutic efficacy. The 1-month CEUS has a high diagnostic accuracy compared with spiral -CT in the usual assessment of percutaneous treatment response.

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Title: Is microbubble-enhanced ultrasonography sufficient for assessment of response to percutaneous treatment in patients with early hepatocellular carcinoma?
Authors: R. Vilana
L. Bianchi
M. Varela
C. Nicolau
M. Sánchez
C. Ayuso
M. García
M. Sala
J. M. Llovet
J. Bruix
C. Bru
BCLC Group
Publication date: 01-11-2006
Publisher: Springer-Verlag
Published in: European Radiology / Issue 11/2006
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-006-0264-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Is microbubble-enhanced ultrasonography sufficient for assessment of response to percutaneous treatment in patients with early hepatocellular carcinoma?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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