Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Archives of Osteoporosis
Published in: Archives of Osteoporosis 1-2/2013

01-12-2013 | Short Communication

Is lung function associated with bone mineral density? Results from the Hertfordshire Cohort Study

Authors: E. M. Dennison, D. K. Dhanwal, S. O. Shaheen, R. Azagra, I. Reading, K. A. Jameson, A. A. Sayer, C. Cooper

Published in: Archives of Osteoporosis | Issue 1-2/2013

Login to get access

Abstract

Summary

Given limited information available regarding associations between lung function and bone mineral density among healthy subjects, we undertook these analyses in the Hertfordshire Cohort Study. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC were not associated with bone mineral density at any site; associations with bone mineral content were removed by adjustment for body size.

Purpose

There is limited information available regarding the association between lung function and bone mineral density among healthy elderly subjects. We addressed this issue in the Hertfordshire Cohort Study.

Methods

From the above cohort, 985 subjects (496 men and 489 women) aged 60–72 years were recruited. All subjects underwent bone density measurements using dual energy X-ray absorptiometry and lung function tests using standardised spirometry. Chronic obstructive pulmonary disease (COPD) was defined as a FEV1/FVC ratio <lower limit of normal, calculated using separate equations for men and women.

Results

Measures of lung function (FEV1, FVC and FEV1/FVC) were not associated with bone mineral density at the lumbar spine, femoral neck and total hip in men or women; associations with bone mineral content and bone area were removed by adjustment for body size and lifestyle confounders. In this cohort, there were no associations observed between COPD and any measure of bone mass.

Conclusions

There was no association between lung function and bone mass in this community dwelling cohort after adjustment for body size and other confounders.
Literature
1.
Graat-Verboom L, Spruit MA, van den Borne BEEM, Smeenk FWJM, Martens EJ, Lunde R, Wouters EFM (2009) Correlates of osteoporosis in chronic obstructive pulmonary disease: an underestimated systemic component. Respir Med 103(8):1143–1151PubMedCrossRef
2.
Jørgensen NR, Schwarz P, Holme I, Henriksen BM, Petersen LJ, Backer V (2007) The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease—a cross sectional study. Respir Med 101(1):177–185PubMedCrossRef
3.
McEvoy CE, Ensrud KE, Bender E, Genant HK, Yu WEI, Griffith JM, Niewoehner DE (1998) Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 157(3):704–709PubMedCrossRef
4.
Ferguson GT, Calverley PMA, Anderson JA, Jenkins CR, Jones PW, Willits LR, Yates JC, Vestbo J, Celli B (2009) Prevalence and progression of osteoporosis in patients with COPD. Chest 136(6):1456–1465PubMedCrossRef
5.
Engelen MPKJ, Schols AMWJ, Heidendal GAK, Wouters EFM (1998) Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 68(6):1298–1303PubMed
6.
Iqbal F, Michaelson J, Thaler L, Rubin J, Roman J, Nanes MS (1999) Declining bone mass in men with chronic pulmonary disease*. Chest 116(6):1616–1624PubMedCrossRef
7.
Bolton CE, Ionescu AA, Shiels KM, Pettit RJ, Edwards PH, Stone MD, Nixon LS, Evans WD, Griffiths TL, Shale DJ (2004) Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 170(12):1286–1293PubMedCrossRef
8.
Bon J, Fuhrman CR, Weissfeld JL, Duncan SR, Branch RA, Chang CCH, Zhang Y, Leader JK, Gur D, Greenspan SL, Sciurba FC (2011) Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohort. Am J Respir Crit Care Med 183(7):885–890PubMedCrossRef
9.
Schlaich C, Minne HW, Bruckner T, Wagner G, Gebest HJ, Grunze M, Zeigler R, Leidig-Bruckner G (1998) Reduced pulmonary function in patients with spinal osteoporotic fractures. Osteoporos Int 8:261–267PubMedCrossRef
10.
Gokkaya NKO, Koseoglu F, Albayrak N (2008) Reduced aerobic capacity in patients with severe osteoporosis: a cross sectional study. Europ J Phys Rehabl Med 44:141–147
11.
Vrieze A, de Greef MHG, Wýkstra PJ, Wempe JB (2007) Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporos Int 18(9):1197–1202PubMedCrossRef
12.
Lekamwasam S, Trivedi DP, Khaw KT (2005) An association between respiratory function and hip bone mineral density in older men: a cross-sectional study. Osteoporos Int 16:204–207PubMedCrossRef
13.
Lekamwasam S, Trivedi DP, Khaw KT (2002) An association between respiratory function and hip bone mineral density in women from the general community: a cross-sectional study. Osteoporos Int 13:710–715PubMedCrossRef
14.
Sin DD, Man JP, Man SFP (2003) The risk of osteoporosis in caucasian men and women with obstructive airways disease. Am J Med 114(1):10–14PubMedCrossRef
15.
Syddall HE, Aihie Sayer A, Dennison EM, Martin HJ, Barker DJ, Cooper C (2005) Cohort profile: the Hertfordshire cohort study. Int J Epidemiol 34:1234–42PubMedCrossRef
16.
Hankinson JL, Odencrantz JR, Fedan KB (1999) Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 159:179–187PubMedCrossRef
17.
de Vries F, van Staa TP, Bracke MSGM, Cooper C, Leufkens HGM, Lammers J-WJ (2005) Severity of obstructive airway disease and risk of osteoporotic fracture. Eur Respir J 25(5):879–884PubMedCrossRef
18.
Hasday JD, McCrea KA, Meltzer SS, Bleeker ER (1994) Dysregulation of airway cytokine expression in chronic obstructive pulmonary disease and asthma. Am J Resp Crit Care Med 150:S54–S58PubMedCrossRef
19.
Manolagas SC (1995) Role of cytokines in bone resorption. Bone 17:S63–S67CrossRef
20.
Shaheen SO, Jameson KA, Robinson SM, Boucher BJ, Syddall HE, Sayer AA, Cooper C, Holloway JW, Dennison EM (2011) Relationships of vitamin D status to adult lung function and COPD. Thorax 66(8):692–8PubMedCrossRef
Metadata
Title
Is lung function associated with bone mineral density? Results from the Hertfordshire Cohort Study
Authors
E. M. Dennison
D. K. Dhanwal
S. O. Shaheen
R. Azagra
I. Reading
K. A. Jameson
A. A. Sayer
C. Cooper
Publication date
01-12-2013
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1-2/2013
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-012-0115-y

Other articles of this Issue 1-2/2013

Archives of Osteoporosis 1-2/2013 Go to the issue

Short Communication

Variation in the days supply field for osteoporosis medications in Ontario

Original Article

Factors associated with osteoporosis in Brazilian women: a population-based household survey

Original Article

Incidence of hip fracture in Rohtak district, North India

Case Report

Effective treatment of a steroid-induced femoral neck fracture nonunion with a once-weekly administration of teriparatide in a rheumatoid patient: a case report

Original Article

Assessing the effect of dietary calcium intake and 25 OHD status on bone turnover in women in Pakistan

Original Article

Does insufficient access to dual-energy X-ray absorptiometry (DXA) stifle the provision of quality osteoporosis care in New Zealand?