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Pediatric Nephrology

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01-04-2006 | Editorial Commentary

Is genetic testing of healthy pre-symptomatic children with possible Alport syndrome ethical?

Authors: Lawrence Copelovitch, Bernard S. Kaplan

Published in: Pediatric Nephrology | Issue 4/2006

Excerpt

“The better part of valor is discretion”

…

Slajpah M, Meglic A, Furlan P, Glavac D (2005) The importance of non-invasive genetic analysis in the initial diagnosis of Alport syndrome in young patients. Pediatr Nephrol 20:1260–1264CrossRefPubMed

Nelson RM, Botkjin JR, Kodish ED, Levetown M, Truman JT, Wilfond BS, Harrison CE, Kazura A, Krug E 3rd, Schwartz PA, Donovan GK, Fallat M, Porter IH, Steinberg D (2001) Committee on bioethics. Ethical issues with genetic testing in pediatrics. Pediatrics 107:1451–1455CrossRefPubMed

Ravine DL, Walker RG, Gibson RN, Forrest SM, Richards RI, Friend K, Sheffield LJ, Kincaid-Smith P, Danks DM (1992) Phenotype and genotype heterogeneity in autosomal dominant polycystic kidney disease. Lancet 340:1330–1333CrossRefPubMed

Marsick R, Limwongse C, Kodish E (1998) Genetic testing for renal diseases: medical and ethical considerations. Am J Kidney Dis 32:943–945

Anonymous (1995) Points to consider: ethical, legal, and psychosocial implications of genetic testing in children and adolescents. American Society of Human Genetics Board of Directors; American College of Medical Genetics Board of Directors. Am J Hum Genet 57:1233–1241

Chapman MA (1992) Canadian experience with predictive testing of Huntington disease: lessons for genetic testing centers and policy makers. Am J Med Genetics 42:491–498CrossRef

Wexler N (1992) The Tiresias complex: Huntington’s disease as a paradigm of testing for late-onset disorders. FASEB J 6:2820–2825PubMed

Jais JP, Kenebelmann B, Giatras I, De Marchi M, Rizzoni G, Renieri A, Weber M, Gross O, Nezter KO, Flinter F, Pirson Y, Verellen C, Wieslander J, Persson U, Tryggvason K, Martin P, Hertz JM, Schroder C, Sanak M, Krejcova S, Carvalho MF, Saus J, Antignac C, Smeets H, Gubler MC (2000) X-linked Alport syndrome: natural history in 195 families and genotype–phenotype correlations in males. J Am Soc Nephrol 11:649–657PubMed

Gross O, Netzer KO, Lambrect R, Seibold S, Weber M (2002) Meta-analysis of genotype–phenotype correlation in X-linked Alport syndrome: impact on clinical counseling. Nephrol Dial Transplant 17:1218–1227CrossRefPubMed

10.

Feld LG, Meyers KE, Kaplan BS, Stapleton FB (1998) Limited evaluation of microscopic hematuria in pediatrics. Pediatrics 102:E42CrossRefPubMed

11.

Bergstein J, Leiser J, Andreoli S (2005) The clinical significance of asymptomatic gross and microscopic hematuria in children. Arch Pediatr Adolesc Med 159:353–355CrossRefPubMed

12.

Diven SC, Travis LB (2000) A practical primary care approach to hematuria in children. Pediatr Nephrol 14:65–72CrossRefPubMed

13.

Rana K, Wang YY, Powell H, Jones C, McCreie D, Buzza M, Udawela M, Savige J (2005) Persistent familial hematuria in children and the locusfor thin basement membrane nephropathy. Pediatr Nephrol 20:1729-1737PubMedCrossRef

Title: Is genetic testing of healthy pre-symptomatic children with possible Alport syndrome ethical?
Authors: Lawrence Copelovitch
Bernard S. Kaplan
Publication date: 01-04-2006
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 4/2006
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-005-0003-4

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Is genetic testing of healthy pre-symptomatic children with possible Alport syndrome ethical?

Excerpt

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