Published in:
01-04-2012 | Endocrine Tumors
Is Focused Minimally Invasive Parathyroidectomy Appropriate for Patients With Familial Primary Hyperparathyroidism?
Authors:
Ruth S. Prichard, FRCSI, Christine J. O’Neill, FRACS, Jennifer J. Oucharek, FRCSC, Rebecca S. Sippel, MD, FACS, Leigh W. Delbridge, MD, FRACS, Stanley B. Sidhu, PhD, FRACS, Herbert Chen, MD, FACS
Published in:
Annals of Surgical Oncology
|
Issue 4/2012
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Abstract
Background
The aim of this study was to determine whether a focused minimally invasive parathyroidectomy (MIP) for patients with primary hyperparathyroidism and concordant pre-operative localization studies is appropriate for patients with a family history of the disease. Familial hyperparathyroidism may be seen as a chronic disease in which recurrence is inevitable. Patients frequently undergo subtotal or total parathyroidectomy for perceived 4-gland parathyroid hyperplasia in an attempt to reduce this risk. Controversy remains regarding whether a MIP is appropriate in this setting.
Methods
Patients undergoing an MIP were identified from prospectively maintained databases. Chart review confirmed the presence of a family history of hyperparathyroidism in a direct relative. Patients with and without a family history were compared regarding overall complications, recurrence, and cure rates.
Results
A total of 1,652 patients underwent a MIP. Of these, 34 patients had a positive family history. There was no statistically significant difference in age, gender, preoperative biochemistry, gland weight, or complication rates between the groups. The cure rate at 6 months from a single operation was equivalent between the 2 groups (97 vs. 98%). With a median of 39 months follow-up, the recurrence rate was higher in those with a family history compared with those without (8.8 vs 1.1%; P = 0.002). Reoperation was successful in the small population of familial patients who did present with recurrent hyperparathyroidism.
Conclusions
The vast majority of patients who underwent a MIP were surgically cured. Although recurrence rates remain higher in the familial hyperparathyroidism group, these data suggest that this alone should not be a contraindication to MIP.