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01-12-2015 | Neurology and Preclinical Neurological Studies - Short communication

Is cognitive stability in Parkinson’s disease a predictable phenomenon? A 5-year follow-up study

Authors: Maria Elena Di Battista, Alfonso Rubino, Marcella Valente, Patrizia Giustini, Nicola Vanacore, Giuseppe Meco

Published in: Journal of Neural Transmission | Issue 12/2015

Abstract

Cognitive disturbances are integral to the course of PD but the rate of cognitive decline remains largely unpredictable. The aim of this study was to determine the clinical features associated with “cognitive stability”. Fifty-four patients (32 with normal cognition and 22 featuring MCI) were recruited in 2009 and re-evaluated after a mean time of 4.7 years; all patients underwent a detailed neuropsychological and clinical evaluation. A proportion of 61 % of patients (19 with normal cognition and 14 with MCI) remained cognitive stable, whereas 39 % had reduced cognitive reserve. After multivariate analysis, only the preservation of visuo-spatial domain was predictive of cognitive stability.

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Title: Is cognitive stability in Parkinson’s disease a predictable phenomenon? A 5-year follow-up study
Authors: Maria Elena Di Battista
Alfonso Rubino
Marcella Valente
Patrizia Giustini
Nicola Vanacore
Giuseppe Meco
Publication date: 01-12-2015
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 12/2015
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-015-1440-2

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Is cognitive stability in Parkinson’s disease a predictable phenomenon? A 5-year follow-up study

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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