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European Journal of Nuclear Medicine and Molecular Imaging

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01-07-2004 | Controversies—Against

Is BMIPP a sensitive marker for myocardial ischaemic stress?

Author: Robert J. Gropler

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 7/2004

Excerpt

Nuclear cardiology has an extensive armemintarium for the characterization and detection of myocardial ischemia and its amelioration. This is exemplified by the the availability of numerous radiotracers to measure myocardial perfusion, hypoxia, substrate metabolism, necrosis, neuronal activity and mechanical function that are used for this purpose. It is now being proposed that the fatty acid analogue, ¹²³I-(p-iodophenyl)-3-(R,S)methyl-pentadecanoic acid (BMIPP), be considered an additional tool. When one is designing a radiotracer for the assessment of ischemic or post-ischemic myocardium certain characteristics are desired.

The myocardial kinetics of the radiotracer reflects a biologic process that is characteristic of the ischemic and/or post-ischemic cascade.
High-quality myocardial images are obained that are readily interpretable.
The information being obtained is independent of the level of myocardial blood flow; and if not, it is at least additive to the flow information.

In this short review the reasons are discussed why BMIPP does not adequately fulfill these criteria and thus, is not an accurate radiotracer to assess either ischemic or post-ischemic myocardium. …

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Title: Is BMIPP a sensitive marker for myocardial ischaemic stress?
Author: Robert J. Gropler
Publication date: 01-07-2004
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 7/2004
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1587-9

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