Published in:
Open Access
01-04-2010 | Meeting abstract
Is amisulpride associated less with neuroleptic malignant syndrome? Review and hypothesis
Authors:
Vaios Peritogiannis, Georgios Kalampokis, Charalampos Lixouriotis
Published in:
Annals of General Psychiatry
|
Special Issue 1/2010
Login to get access
Excerpt
Atypical antipsychotics have been reported to induce neuroleptic malignant syndrome (NMS). The precise pathophysiologic mechanism is unknown but dopamine blockage is pivotal. The serotoninergic action of atypical antipsychotics may also been implicated because serotonin may inhibit dopamine release and worsen hypodopaminergic states. Amisulpride, which is a selective D2/D3 receptor antagonist and has no affinity for serotonin receptors may be less associated with the development of NMS. …