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Irish Journal of Medical Science (1971 -)

16-03-2024 | Iron Deficiency Anemia | Original Article

Roles of ghrelin, hepcidin and HIF-2α in iron metabolism in iron deficiency anemia

Authors: Esra Rizaogullari Guzel, Nihan Cansel Sarkaya, Ayşegul Ugur Kurtoglu, Volkan Karakus, Erdal Kurtoglu

Published in: Irish Journal of Medical Science (1971 -)

Abstract

Objectives

This study investigates the roles of HIF-2α, hepcidin, and ghrelin in iron deficiency anemia (IDA), the most widespread nutritional disorder globally.

Material and methods

Fifty IDA patients (18–50 years, BMI 19–25) and 40 healthy volunteers were studied. Hemoglobin, ferritin, hepcidin, HIF-2α, and ghrelin levels were analyzed.

Results

IDA patients showed lower hemoglobin, ferritin, hepcidin, and ghrelin levels than the control group, but HIF-2α levels were similar. Positive correlations were observed in both groups between hepcidin and HIF-2α (p < 0.001), hepcidin and ghrelin (p < 0.001), and HIF-2α and ghrelin (p < 0.001). Hemoglobin was correlated positively with HIF-2α, and ferritin was correlated positively with HIF-2α in the patient group.

Conclusion

The study suggests that the low hepcidin levels in IDA patients enhance iron absorption. The lack of significant HIF-2α level differences may be due to the absence of chronic hypoxia in current hemoglobin levels of IDA patients. Moreover, the low ghrelin levels in patients and the correlations between ghrelin, hepcidin, and HIF-2α in both groups indicate their involvement in iron metabolism.

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Title: Roles of ghrelin, hepcidin and HIF-2α in iron metabolism in iron deficiency anemia
Authors: Esra Rizaogullari Guzel
Nihan Cansel Sarkaya
Ayşegul Ugur Kurtoglu
Volkan Karakus
Erdal Kurtoglu
Publication date: 16-03-2024
Publisher: Springer International Publishing
Keywords: Iron Deficiency Anemia
Iron Deficiency
Anemia
Published in: Irish Journal of Medical Science (1971 -)
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-024-03655-z

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