Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Cardiovascular Toxicology
Published in: Cardiovascular Toxicology 7-8/2023

17-07-2023 | Ionizing Radiation

The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations

Authors: Murat Cimci, Bahadir Batar, Merve Bostanci, Eser Durmaz, Bahadir Karayel, Damla Raimoglou, Mehmet Guven, Bilgehan Karadag

Published in: Cardiovascular Toxicology | Issue 7-8/2023

Login to get access

Abstract

Ionizing radiation (IR) exposures have increased exponentially in recent years due to the rise in diagnostic and therapeutic interventions. A number of small-scale studies investigated the long-term effect of IR on health workers or immediate effects of IR on patients undergoing catheterization procedures; however, the long-term impact of multiple cardiac catheterizations on DNA damage on a patient population is not known. In this study, the effects of IR on DNA damage, based on micronuclei (MN) frequency and 8-hydroxy-2′-deoxyguanosine (8-OHdG) as markers in peripheral lymphocytes, were evaluated in patients who previously underwent multiple cardiac catheterization procedures. Moreover, genetic polymorphisms in genes PARP1 Val762Ala, OGG1 Ser326Cys, and APE1 Asn148Glu as a measure of sensitivity to radiation exposure were also investigated in the same patient population. The patients who underwent ≥ 3 cardiac catheterization procedures revealed higher DNA injury in comparison to the patients who underwent ≤ 2 procedures, documented with the presence of higher level of MN frequency (6.4 ± 4.8 vs. 9.1 ± 4.3, p = 0.002) and elevated serum 8-OHdG levels (33.7 ± 3.8 ng/mL vs. 17.4 ± 1.9 ng/mL, p = 0.001). Besides, OGG1 Ser326Cys and APE1 Asn148Glu heterozygous and homozygous polymorphic types, which are related with DNA repair mechanisms, were significantly associated with MN frequency levels (p = 0.006 for heterozygous and p = 0.001 for homozygous with respect to OGG1 Ser326Cys, p = 0.007 for heterozygous and p = 0.001 for homozygous with respect to APE1 Asn148Glu). There was no significant difference in terms of PARP1 Val762Ala gene polymorphism between two groups.
Literature
1.
Nowbar, A. N., Gitto, M., Howard, J. P., Francis, D. P., & Al-Lamee, R. (2019). Mortality from ischemic heart disease. Circulation Cardiovascular Quality and Outcomes, 12, e005375.CrossRefPubMedPubMedCentral
2.
Andreassi, M. G., Cioppa, A., Manfredi, S., Palmieri, C., Botto, N., & Picano, E. (2007). Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures. European Heart Journal, 28, 2195–2199.CrossRefPubMed
3.
Borrego-Soto, G., Ortiz-López, R., & Rojas-Martínez, A. (2015). Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer. Genetics and Molecular Biology, 38, 420–432.CrossRefPubMedPubMedCentral
4.
Hirshfeld, J. W., Jr., Ferrari, V. A., Bengel, F. M., Bergersen, L., Chambers, C. E., Einstein, A. J., Eisenberg, M. J., Fogel, M. A., Gerber, T. C., Haines, D. E., Laskey, W. K., Limacher, M. C., Nichols, K. J., Pryma, D. A., Raff, G. L., Rubin, G. D., Smith, D., Stillman, A. E., Thomas, S. A., … Wann, L. S. (2018). 2018 ACC/HRS/NASCI/SCAI/SCCT expert consensus document on optimal use of ionizing radiation in cardiovascular imaging: best practices for safety and effectiveness: A report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways. Journal of the American College of Cardiology, 71, e283–e351.CrossRefPubMed
5.
Upton, A. C. (2003). The state of the art in the 1990’s: NCRP Report No. 136 on the scientific bases for linearity in the dose-response relationship for ionizing radiation. Health Physics, 85, 15–22.CrossRefPubMed
6.
Koutsoukis, A., Ntalianis, A., Repasos, E., Kastritis, E., Dimopoulos, M. A., & Paraskevaidis, I. (2018). Cardio-oncology: A focus on cardiotoxicity. European Cardiology, 13, 64–69.CrossRefPubMedPubMedCentral
7.
Luzhna, L., Kathiria, P., & Kovalchuk, O. (2013). Micronuclei in genotoxicity assessment: From genetics to epigenetics and beyond. Frontiers in Genetics, 4, 131.CrossRefPubMedPubMedCentral
8.
Fenech, M. (1998). Important variables that influence base-line micronucleus frequency in cytokinesis-blocked lymphocytes-a biomarker for DNA damage in human populations. Mutation Research, 404, 155–165.CrossRefPubMed
9.
Gao, Y., Wang, P., Wang, Z., Han, L., Li, J., Tian, C., Zhao, F., Wang, J., Zhao, F., Zhang, Q., & Lyu, Y. (2019). Serum 8-hydroxy-2′-deoxyguanosine level as a potential biomarker of oxidative DNA damage induced by ionizing radiation in human peripheral blood. Dose Response, 17, 1559325818820649.CrossRefPubMedPubMedCentral
10.
Andreassi, M. G., Foffa, I., Manfredi, S., Botto, N., Cioppa, A., & Picano, E. (2009). Genetic polymorphisms in XRCC1, OGG1, APE1 and XRCC3 DNA repair genes, ionizing radiation exposure and chromosomal DNA damage in interventional cardiologists. Mutation Research, 666, 57–63.CrossRefPubMed
11.
Cornetta, T., Festa, F., Testa, A., & Cozzi, R. (2006). DNA damage repair and genetic polymorphisms: Assessment of individual sensitivity and repair capacity. International Journal of Radiation Oncology Biology Physics, 66, 537–545.CrossRefPubMed
12.
Vodicka, P., Kumar, R., Stetina, R., Sanyal, S., Soucek, P., Haufroid, V., Dusinska, M., Kuricova, M., Zamecnikova, M., Musak, L., Buchancova, J., Norppa, H., Hirvonen, A., Vodickova, L., Naccarati, A., Matousu, Z., & Hemminki, K. (2004). Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA. Carcinogenesis, 25, 757–763.CrossRefPubMed
13.
Angelini, S., Kumar, R., Carbone, F., Maffei, F., Forti, G. C., Violante, F. S., Lodi, V., Curti, S., Hemminki, K., & Hrelia, P. (2005). Micronuclei in humans induced by exposure to low level of ionizing radiation: Influence of polymorphisms in DNA repair genes. Mutation Research, 570, 105–117.CrossRefPubMed
14.
Elmaraezy, A., Ebraheem Morra, M., Tarek Mohammed, A., Al-Habaa, A., Elgebaly, A., Abdelmotaleb Ghazy, A., Khalil, A. M., Tien Huy, N., & Hirayama, K. (2017). Risk of cataract among interventional cardiologists and catheterization lab staff: A systematic review and meta-analysis. Catheterization and Cardiovascular Interventions, 90, 1–9.CrossRefPubMed
15.
Fenech, M. (2006). Cytokinesis-block micronucleus assay evolves into a “cytome” assay of chromosomal instability, mitotic dysfunction and cell death. Mutation Research, 600, 58–66.CrossRefPubMed
16.
Vral, A., Fenech, M., & Thierens, H. (2011). The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure. Mutagenesis, 26, 11–17.CrossRefPubMed
17.
Sari-Minodier, I., Orsière, T., Auquier, P., Martin, F., & Botta, A. (2007). Cytogenetic monitoring by use of the micronucleus assay among hospital workers exposed to low doses of ionizing radiation. Mutation Research, 629, 111–121.CrossRefPubMed
18.
Cohen, S., Liu, A., Gurvitz, M., Guo, L., Therrien, J., Laprise, C., Kaufman, J. S., Abrahamowicz, M., & Marelli, A. J. (2018). Exposure to low-dose ionizing radiation from cardiac procedures and malignancy risk in adults with congenital heart disease. Circulation, 137, 1334–1345.CrossRefPubMed
19.
Cai, L., Welsh, J. S., & Pennington, C. W. (2018). Letter by Cai et al regarding article, “Exposure to low-dose ionizing radiation from cardiac procedures and malignancy risk in adults with congenital heart disease.” Circulation, 138, 1377–1378.CrossRefPubMed
20.
Doss, M. (2018). Radiation dose from cardiac catheterization procedures in young patients may not contribute to increased cancer risk. European Journal of Epidemiology, 33, 425–426.CrossRefPubMed
21.
Qian, Q. Z., Cao, X. K., Shen, F. H., & Wang, Q. (2016). Effects of ionising radiation on micronucleus formation and chromosomal aberrations in Chinese radiation workers. Radiation Protection Dosimetry, 168, 197–203.PubMed
22.
Pilger, A., & Rüdiger, H. W. (2006). 8-Hydroxy-2’-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. International Archives of Occupational and Environmental Health, 80, 1–15.CrossRefPubMed
23.
Peng, Q., Lu, Y., Lao, X., Chen, Z., Li, R., Sui, J., Qin, X., & Li, S. (2014). Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: A meta-analysis. Diagnostic Pathology, 9, 108.CrossRefPubMedPubMedCentral
24.
Milić, M., Rozgaj, R., Kašuba, V., Jazbec, A. M., Starčević, B., Lyzbicki, B., Ravegnini, G., Zenesini, C., Musti, M., Hrelia, P., & Angelini, S. (2015). Polymorphisms in DNA repair genes: Link with biomarkers of the CBMN cytome assay in hospital workers chronically exposed to low doses of ionising radiation. Arhiv za Higijenu Rada i Toksikologiju, 66, 109–120.CrossRefPubMed
Metadata
Title
The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations
Authors
Murat Cimci
Bahadir Batar
Merve Bostanci
Eser Durmaz
Bahadir Karayel
Damla Raimoglou
Mehmet Guven
Bilgehan Karadag
Publication date
17-07-2023
Publisher
Springer US
Published in
Cardiovascular Toxicology / Issue 7-8/2023
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-023-09801-w