Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Medical Imaging
Published in: BMC Medical Imaging 1/2017

Open Access 01-12-2017 | Research article

Iodine concentration calculated by dual-energy computed tomography (DECT) as a functional parameter to evaluate thyroid metabolism in patients with hyperthyroidism

Authors: Duong Duc Binh, Takahito Nakajima, Hidenori Otake, Tetsuya Higuchi, Yoshito Tsushima

Published in: BMC Medical Imaging | Issue 1/2017

Login to get access

Abstract

Background

Thyroid function in patients with Grave’s disease is usually evaluated by thyroid scintigraphy with radioactive iodine. Recently, dual-energy computed tomography (DECT) with two different energy X-rays can calculate iodine concentrations and can be applied for iodine measurements in thyroid glands. This study aimed to assess the potential use of DECT for the functional assessment of the thyroid gland.

Methods

Thirteen patients with Grave’s disease treated at our hospital from May to September 2015 were included in this retrospective study. Before treatments, all subjects had undergone both iodine scintigraphy [three and 24 h after oral administration of 123I (20 μCi)] and non-enhanced DECT. The region of interests (ROIs) were placed in both lobes of the thyroid glands, and CT values (HU: Hounsfield unit) and iodine concentrations (mg/mL) calculated from DECT images were measured. The correlation between CT values and iodine concentrations from DECT in the thyroid gland was evaluated and then the iodine concentrations were compared with radioactive iodine uptake ratios by thyroid scintigraphy.

Results

Mean (±SD) 123I uptake increased from 46.3 (±22.2) % (range, 11.1–80.1) at 3 h, to 66.5 (±15.2) % (range, 40.0–86.1) at 24 h (p < 0.01). CT values ranged from 34.5 to 98.7 HU [mean: 67.8 (±18.6)], while the iodine concentrations calculated with DECT ranged from 0.0 to 1.3 mg/mL [mean: 0.5 (±0.4)]. A moderate positive correlation between CT values and the calculated iodine concentrations in the thyroid gland was seen (R = 0.429, p < 0.05). A significant negative correlation between 123I uptake at 3 h and iodine concentration by DECT were seen (R = −0.680, p < 0.05), although no correlation was observed between 123I uptake at 3 h and CT values (p = 0.087). No correlation was observed between 123I uptake at 24 h and CT values (p = 0.153) or that between 123I uptake at 24 h and iodine concentration by DECT (p = 0.073).

Conclusion

The negative correlation of 123I uptake at 3 h with iodine concentration evaluated by DECT was better than that observed with simple CT value. DECT may have a potential role in the evaluation of iodine turnover in hyperthyroid patients.
Literature
1.
Baskin HJ, Cobin RH, Duick DS, Gharib H, Guttler RB, Kaplan MM, Segal RL, Garber JR, Hamilton CR Jr, Handelsman Y, et al. American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract. 2002;8(6):457–69.CrossRef
2.
Bahn Chair RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593–646.CrossRefPubMed
3.
Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, Pessah-Pollack R, Singer PA, Woeber KA. American Association of Clinical E et al: clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988–1028.CrossRefPubMed
4.
Kita T, Yokoyama K, Kinuya S, Taki J, Michigishi T, Tonami N. Single dose planning for radioiodine-131 therapy of Graves’ disease. Ann Nucl Med. 2004;18(2):151–5.CrossRefPubMed
5.
Silberstein EB, Alavi A, Balon HR, Clarke SE, Divgi C, Gelfand MJ, Goldsmith SJ, Jadvar H, Marcus CS, Martin WH, et al. The SNMMI practice guideline for therapy of thyroid disease with 131I 3.0. J Nucl Med. 2012;53(10):1633–51.CrossRefPubMed
6.
Nygaard B, Nygaard T, Jensen LI, Court-Payen M, Soe-Jensen P, Nielsen KG, Fugl M, Hansen JM. Iohexol: effects on uptake of radioactive iodine in the thyroid and on thyroid function. Acad Radiol. 1998;5(6):409–14.CrossRefPubMed
7.
Lautenschlaeger IE, Hartmann A, Sicken J, Mohrs S, Scholz VB, Neiger R, Kramer M. Comparison between computed tomography and 99mTc- pertechnetate scintigraphy characteristics of the thyroid gland in cats with hyperthyroidism. Vet Radiol Ultrasound. 2013;54(6):666–73.PubMed
8.
Brown CL, Hartman RP, Dzyubak OP, Takahashi N, Kawashima A, McCollough CH, Bruesewitz MR, Primak AM, Fletcher JG. Dual-energy CT iodine overlay technique for characterization of renal masses as cyst or solid: a phantom feasibility study. Eur Radiol. 2009;19(5):1289–95.CrossRefPubMed
9.
Chandarana H, Megibow AJ, Cohen BA, Srinivasan R, Kim D, Leidecker C, Macari M. Iodine quantification with dual-energy CT: phantom study and preliminary experience with renal masses. Am J Roentgenol. 2011;196(6):693–700.CrossRef
10.
Graser A, Johnson TR, Chandarana H, Macari M. Dual energy CT: preliminary observations and potential clinical applications in the abdomen. Eur Radiol. 2009;19(1):13–23.CrossRefPubMed
11.
Johnson TR. Dual-energy CT: general principles. Am J Roentgenol. 2012;199(5 Suppl):S3–8.CrossRef
12.
Hansmann J, Apfaltrer P, Zoellner FG, Henzler T, Meyer M, Weisser G, Schoenberg SO, Attenberger UI. Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI. World J Radiol. 2013;5(5):202–7.CrossRefPubMedPubMedCentral
13.
Kaza RK, Platt JF, Cohan RH, Caoili EM, Al-Hawary MM, Wasnik A. Dual-energy CT with single- and dual-source scanners: current applications in evaluating the genitourinary tract. Radiographics. 2012;32(2):353–69.CrossRefPubMed
14.
McCollough CH, Leng S, Yu L, Fletcher JG. Dual- and multi-energy CT: principles, technical approaches, and clinical applications. Radiology. 2015;276(3):637–53.CrossRefPubMedPubMedCentral
15.
Koonce JD, Vliegenthart R, Schoepf UJ, Schmidt B, Wahlquist AE, Nietert PJ, Bastarrika G, Flohr TG, Meinel FG. Accuracy of dual-energy computed tomography for the measurement of iodine concentration using cardiac CT protocols: validation in a phantom model. Eur Radiol. 2014;24(2):512–8.CrossRefPubMed
16.
Cherniack RM. Evaluation of respiratory function in health and disease. Dis Mon. 1992;38(7):505–76.CrossRefPubMed
17.
Li Z, Clarke JA, Ketcham RA, Colbert MW, Yan F. An investigation of the efficacy and mechanism of contrast-enhanced X-ray computed tomography utilizing iodine for large specimens through experimental and simulation approaches. BMC Physiol. 2015;15:5.CrossRefPubMedPubMedCentral
18.
Wang L, Liu B, Wu XW, Wang J, Zhou Y, Wang WQ, Zhu XH, Yu YQ, Li XH, Zhang S, et al. Correlation between CT attenuation value and iodine concentration in vitro: discrepancy between gemstone spectral imaging on single-source dual-energy CT and traditional polychromatic X-ray imaging. J Med Imaging Radiat Oncol. 2012;56(4):379–83.CrossRefPubMed
19.
Barrett JF, Keat N. Artifacts in CT: recognition and avoidance. Radiographics. 2004;24(6):1679–91.CrossRefPubMed
20.
Ginat DT, Mayich M, Daftari-Besheli L, Gupta R. Clinical applications of dual-energy CT in head and neck imaging. Eur Arch Otorhinolaryngol. 2016;273(3):547–53.CrossRefPubMed
Metadata
Title
Iodine concentration calculated by dual-energy computed tomography (DECT) as a functional parameter to evaluate thyroid metabolism in patients with hyperthyroidism
Authors
Duong Duc Binh
Takahito Nakajima
Hidenori Otake
Tetsuya Higuchi
Yoshito Tsushima
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2017
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/s12880-017-0216-6

Other articles of this Issue 1/2017

BMC Medical Imaging 1/2017 Go to the issue

Case report

Case report of hyperglycemic nonketotic chorea with rapid radiological resolution

Research article

The diagnostic performance of 18F-FAMT PET and 18F-FDG PET for malignancy detection: a meta-analysis

Research article

Rapid Cartesian versus radial acquisition: comparison of two sequences for hepatobiliary phase MRI at 3 tesla in patients with impaired breath-hold capabilities

Research article

Testing of the assisting software for radiologists analysing head CT images: lessons learned

Case report

Radiographic features of Ollier’s disease – two case reports

Research article

Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models