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01-12-2017 | Original Paper

Involvement of IL-17 in Secondary Brain Injury After a Traumatic Brain Injury in Rats

Authors: Tan Li, Yong-mei Zhang, Dong Han, Rong Hua, Bing-nan Guo, Shu-qun Hu, Xian-liang Yan, Tie Xu

Published in: NeuroMolecular Medicine | Issue 4/2017

Abstract

The pro-inflammatory activity of interleukin 17, which is produced by the IL-23/IL-17 axis, has been associated with the pathogenesis of traumatic brain injury (TBI). The study investigated the potential role of IL-17 in secondary brain injury of TBI in a rat model. Our data showed that the levels of IL-17 increased from 6 h to 7 days and peaked at 3 days, in both the CNS and serum, which were consistent with the severity of secondary brain injury. The IL-23 inhibitor suberoylanilide hydroxamic acid (SAHA) treatment markedly decreased the expressions of IL-17 and apoptosis-associated proteins cleaved caspase-3 and increased the protein ratio of Bcl-2 (B cell lymphoma/leukemia-2)/Bax (Bcl-2-associated X protein). Meanwhile, neuronal apoptosis was reduced, and neural function was improved after SAHA treatment. This study suggests that IL-17 is involved in secondary brain injury after TBI. Administering an IL-23 inhibitor and thereby blocking the IL-23/IL-17 axis may be beneficial in the treatment of TBI.

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Title: Involvement of IL-17 in Secondary Brain Injury After a Traumatic Brain Injury in Rats
Authors: Tan Li
Yong-mei Zhang
Dong Han
Rong Hua
Bing-nan Guo
Shu-qun Hu
Xian-liang Yan
Tie Xu
Publication date: 01-12-2017
Publisher: Springer US
Published in: NeuroMolecular Medicine / Issue 4/2017
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-017-8468-4

At a glance: The STEP trials

Springer Medicine

Involvement of IL-17 in Secondary Brain Injury After a Traumatic Brain Injury in Rats

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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