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01-10-2007 | Pediatric

Investigation of normal organ development with fetal MRI

Authors: Daniela Prayer, Peter C. Brugger

Published in: European Radiology | Issue 10/2007

Abstract

The understanding of the presentation of normal organ development on fetal MRI forms the basis for recognition of pathological states. During the second and third trimesters, maturational processes include changes in size, shape and signal intensities of organs. Visualization of these developmental processes requires tailored MR protocols. Further prerequisites for recognition of normal maturational states are unequivocal intrauterine orientation with respect to left and right body halves, fetal proportions, and knowledge about the MR presentation of extrafetal/intrauterine organs. Emphasis is laid on the demonstration of normal MR appearance of organs that are frequently involved in malformation syndromes. In addition, examples of time-dependent contrast enhancement of intrauterine structures are given.

Stazzone MM, Hubbard AM, Bilaniuk LT, Harty MP, Meyer JS, Zimmerman RA, Mahboubi S (2000) Ultrafast MR imaging of the normal posterior fossa in fetuses. AJR Am J Roentgenol 175:835–839PubMed

Brugger PC, Stuhr F, Lindner C, Prayer D (2006) Methods of fetal MR: beyond T2-weighted imaging. Eur J Radiol 57:172-178, DOI 110.1016/j.ejrad.2005.1011.1017 PubMedCrossRef

Girard N, Raybaud C, Poncet M (1995) In vivo MR study of brain maturation in normal fetuses. AJNR Am J Neuroradiol 16:407–413PubMed

Garel C, Chantrel E, Brisse H, Elmaleh M, Luton D, Oury JF, Sebag G, Hassan M (2001) Fetal cerebral cortex: normal gestational landmarks identified using prenatal MR imaging. AJNR Am J Neuroradiol 22:184–189PubMed

Prayer D, Kasprian G, Krampl E, Ulm B, Witzani L, Prayer L, Brugger PC (2006) MRI of normal fetal brain development. Eur J Radiol 57:199–216, DOI 110.1016/j.ejrad.2005.1011.1020 PubMedCrossRef

Pang MW, Leung TN, Sahota DS, Lau TK, Chang AM (2003) Customizing fetal biometric charts. Ultrasound Obstet Gynecol 22:271–276, DOI 210.1002/uog.1196 PubMedCrossRef

Salomon LJ, Bernard JP, Duyme M, Buvat I, Ville Y (2005) The impact of choice of reference charts and equations on the assessment of fetal biometry. Ultrasound Obstet Gynecol 25:559–565, DOI 510.1002/uog.1901 PubMedCrossRef

Garel C (2005) Fetal cerebral biometry: normal parenchymal findings and ventricular size. Eur Radiol 15:809–813, DOI 810.1007/s00330-00004-02610-z PubMedCrossRef

Duncan KR, Issa B, Moore R, Baker PN, Johnson IR, Gowland PA (2005) A comparison of fetal organ measurements by echo-planar magnetic resonance imaging and ultrasound. BJOG 112:43–49, DOI 10.1111/j.1471-0528.2004.00318.x PubMedCrossRef

10.

Witzani L, Brugger PC, Hormann M, Kasprian G, Csapone-Balassy C, Prayer D (2006) Normal renal development investigated with fetal MRI. Eur J Radiol 57:294–302, DOI 210.1016/j.ejrad.2005.1011.1027 PubMedCrossRef

11.

Tanigaki S, Miyakoshi K, Tanaka M, Hattori Y, Matsumoto T, Ueno K, Uehara K, Nishimura O, Minegishi K, Ishimoto H, Shinmoto H, Ikeda K, Yoshimura Y (2004) Pulmonary hypoplasia: prediction with use of ratio of MR imaging-measured fetal lung volume to US-estimated fetal body weight. Radiology 232:767–772, DOI 710.1148/radiol.2323030359 PubMedCrossRef

12.

Hassibi S, Farhataziz N, Zaretsky M, McIntire D, Twickler DM (2004) Optimization of fetal weight estimates using MRI: comparison of acquisitions. AJR Am J Roentgenol 183:487–492PubMed

13.

Brugger PC, Mittermayer C, Prayer D (2006) A new look at the fetus: thick-slab T2-weighted sequences in fetal MRI. Europ J Radiol 57:182–186, DOI 110.1016/j.ejrad.2005.1011.1018 CrossRef

14.

Haak MC, van Vugt JM (2003) Pathophysiology of increased nuchal translucency: a review of the literature. Hum Reprod Update 9:175–184PubMedCrossRef

15.

Bamberg C, Kalache KD (2004) Prenatal diagnosis of fetal growth restriction. Semin Fetal Neonatal Med 9:387–394, DOI 310.1016/j.siny.2004.1003.1007 PubMedCrossRef

16.

Mangels KJ, Tulipan N, Tsao LY, Alarcon J, Bruner JP (2000) Fetal MRI in the evaluation of intrauterine myelomeningocele. Pediatr Neurosurg 32:124–131, DOI 110.1159/000028916 PubMedCrossRef

17.

Fogliarini C, Chaumoitre K, Chapon F, Fernandez C, Levrier O, Figarella-Branger D, Girard N (2005) Assessment of cortical maturation with prenatal MRI. Part I: normal cortical maturation. Eur Radiol 15:1671–1685, DOI 1610.1007/s00330-00005-02782-00331 PubMedCrossRef

18.

Suri M (2005) Craniofacial syndromes. Semin Fetal Neonatal Med 10:243–257PubMedCrossRef

19.

Shinmoto H, Kashima K, Yuasa Y, Tanimoto A, Morikawa Y, Ishimoto H, Yoshimura Y, Hiramatsu K (2000) MR imaging of non-CNS fetal abnormalities: a pictorial essay. Radiographics 20:1227–1243PubMed

20.

Brugger PC, Prayer D (2005) Magnetic resonance imaging (MRI) of the perinatal thyroid gland. Europ Radiol 15(Suppl):B-576

21.

Liechty KW, Crombleholme TM, Flake AW, Morgan MA, Kurth CD, Hubbard AM, Adzick NS (1997) Intrapartum airway management for giant fetal neck masses: the EXIT (ex utero intrapartum treatment) procedure. Am J Obstet Gynecol 177:870–874PubMedCrossRef

22.

Kathary N, Bulas DI, Newman KD, Schonberg RL (2001) MRI imaging of fetal neck masses with airway compromise: utility in delivery planning. Pediatr Radiol 31:727–731PubMedCrossRef

23.

Baker PN, Johnson IR, Gowland PA, Freeman A, Adams V, Mansfield P (1994) Estimation of fetal lung volume using echo-planar magnetic resonance imaging. Obstet Gynecol 83:951–954PubMedCrossRef

24.

Osada H, Kaku K, Masuda K, Iitsuka Y, Seki K, Sekiya S (2004) Quantitative and qualitative evaluations of fetal lung with MR imaging. Radiology 231:887–892, DOI 810.1148/radiol.2313021689 PubMedCrossRef

25.

Keller TM, Rake A, Michel SC, Seifert B, Wisser J, Marincek B, Kubik-Huch RA (2004) MR assessment of fetal lung development using lung volumes and signal intensities. Eur Radiol 14:984–989, DOI 910.1007/s00330-00004-02256-x PubMedCrossRef

26.

Brewerton LJ, Chari RS, Liang Y, Bhargava R (2005) Fetal lung-to-liver signal intensity ratio at MR imaging: development of a normal scale and possible role in predicting pulmonary hypoplasia in utero. Radiology 235:1005–1010, DOI 1010.1148/radiol.2353040280 PubMedCrossRef

27.

Kasprian G, Balassy C, Brugger PC, Prayer D (2006) MRI of normal and pathological fetal lung development. Eur J Radiol 57:261–270, DOI 210.1016/j.ejrad.2005.1011.1031 PubMedCrossRef

28.

Moore RJ, Strachan B, Tyler DJ, Baker PN, Gowland PA (2001) In vivo diffusion measurements as an indication of fetal lung maturation using echo planar imaging at 0.5 T. Magn Reson Med 45:247–253PubMedCrossRef

29.

Chaoui R, Kalache KD, Heling KS, Tennstedt C, Bommer C, Korner H (2002) Absent or hypoplastic thymus on ultrasound: a marker for deletion 22q11.2 in fetal cardiac defects. Ultrasound Obstet Gynecol 20:546–552PubMedCrossRef

30.

Langer JC, Hussain H, Khan A, Minkes RK, Gray D, Siegel M, Ryan G (2001) Prenatal diagnosis of esophageal atresia using sonography and magnetic resonance imaging. J Pediatr Surg 36:804–807, DOI 810.1053/jpsu.2001.22965 PubMedCrossRef

31.

Shinmoto H, Kuribayashi S (2003) MRI of fetal abdominal abnormalities. Abdom Imaging 28:877–886, DOI 810.1007/s00261-00003-00047-00265 PubMedCrossRef

32.

Verstraelen H, Vanzieleghem B, Defoort P, Vanhaesebrouck P, Temmerman M (2003) Prenatal ultrasound and magnetic resonance imaging in fetal varicella syndrome: correlation with pathology findings. Prenat Diagn 23:705–709, DOI 710.1002/pd.1669 PubMedCrossRef

33.

Brugger PC, Prayer D (2006) Fetal abdominal magnetic resonance imaging. Eur J Radiol 57:278–293, DOI 210.1016/j.ejrad.2005.1011.1030 PubMedCrossRef

34.

Veyrac C, Couture A, Saguintaah M, Baud C (2004) MRI of fetal GI tract abnormalities. Abdom Imaging 29:411–420, DOI 410.1007/s00261-00003-00147-00262 PubMedCrossRef

35.

Saguintaah M, Couture A, Veyrac C, Baud C, Quere M-P (2002) MRI of the fetal gastrointestinal tract. Pediatr Radiol 32:395–404, DOI 310.1007/s00247-00001-00607-00241 PubMedCrossRef

36.

Duncan KR, Baker PN, Gowland PA, Issa B, Moore R, Worthington B, Johnson IR (1997) Demonstration of changes in fetal liver erythropoiesis using echo-planar magnetic resonance imaging. Am J Physiol 273:G965–G967PubMed

37.

Martin C, Darnell A, Duran C, Bermudez P, Mellado F, Rigol S (2004) Magnetic resonance imaging of the intrauterine fetal genitourinary tract: normal anatomy and pathology. Abdom Imaging 29:286–302, DOI 210.1007/s00261-00003-00105-z PubMedCrossRef

38.

Brunelle F (2001) Fetal imaging in a new era. Ultrasound Obstet Gynecol 18:91–95PubMedCrossRef

39.

Blaicher W, Mittermayer C, Messerschmidt A, Deutinger J, Bernaschek G, Prayer D (2004) Fetal skeletal deformities-the diagnostic accuracy of prenatal ultrasonography and fetal magnetic resonance imaging. Ultraschall Med 25:195–199, DOI 110.1055/s-2004-812946 PubMedCrossRef

40.

Parilla BV, Leeth EA, Kambich MP, Chilis P, MacGregor SN (2003) Antenatal detection of skeletal dysplasias. J Ultrasound Med 22:255–258PubMed

41.

Sentilhes L, Verspyck E, Patrier S, Eurin D, Lechevallier J, Marpeau L (2003) Amniotic band syndrome: pathogenesis, prenatal diagnosis and neonatal management. J Gynecol Obstet Biol Reprod (Paris) 32:693–704

42.

Kos M, Hafner T, Funduk-Kurjak B, Bozek T, Kurjak A (2002) Limb deformities and three-dimensional ultrasound. J Perinat Med 30:40–47PubMedCrossRef

43.

Witters I, Moerman P, Fryns JP (2002) Fetal akinesia deformation sequence: a study of 30 consecutive in utero diagnoses. Am J Med Genet 113:23–28, DOI 10.1002/ajmg.10698 PubMedCrossRef

44.

von Kleist-Retzow JC, Cormier-Daire V, Viot G, Goldenberg A, Mardach B, Amiel J, Saada P, Dumez Y, Brunelle F, Saudubray JM, Chretien D, Rotig A, Rustin P, Munnich A, De Lonlay P (2003) Antenatal manifestations of mitochondrial respiratory chain deficiency. J Pediatr 143:208–212, DOI 210.1067/S0022-3476(1003)00130-00136 CrossRef

45.

Mulder EJ, Nikkels PG, Visser GH (2001) Fetal akinesia deformation sequence: behavioral development in a case of congenital myopathy. Ultrasound Obstet Gynecol 18:253–257, DOI 210.1046/j.1469-0705.2001.00422.x PubMedCrossRef

46.

Ippolito E (1995) Update on pathologic anatomy of clubfoot. J Pediatr Orthop B 4:17–24PubMed

47.

Beals RK (2005) The distal arthrogryposes: a new classification of peripheral contractures. Clin Orthop Relat Res 435:203–210PubMedCrossRef

48.

Yfantis H, Nonaka D, Castellani R, Harman C, Sun CC (2002) Heterogeneity in fetal akinesia deformation sequence (FADS): autopsy confirmation in three 20–21-week fetuses. Prenat Diagn 22:42–47, DOI 10.1002/pd.1234 PubMedCrossRef

49.

Vasta I, Kinali M, Messina S, Guzzetta A, Kapellou O, Manzur A, Cowan F, Muntoni F (2005) Can clinical signs identify newborns with neuromuscular disorders? J Pediatr 1:73–79, DOI 10.1016/j.jpeds.2004.1008.1047

50.

Sekulic SR, Lukac DD, Naumovic NM (2005) The fetus cannot exercise like an astronaut: gravity loading is necessary for the physiological development during second half of pregnancy. Med Hypotheses 64:221–228, DOI 210.1016/j.mehy.2004.1008.1012 PubMedCrossRef

51.

Sival DA, van Weerden TW, Vles JS, Timmer A, den Dunnen WF, Staal-Schreinemachers AL, Hoving EW, Sollie KM, Kranen-Mastenbroek VJ, Sauer PJ, Brouwer OF (2004) Neonatal loss of motor function in human spina bifida aperta. Pediatrics 114:427–434, DOI 410.1542/peds.1114.1542.1427 PubMedCrossRef

52.

Gowland P (2005) Placental MRI. Semin Fetal Neonatal Med 10:485–490, DOI 410.1016/j.siny.2005.1005.1001 PubMed

53.

Blaicher W, Brugger PC, Mittermayer C, Schwindt J, Deutinger J, Bernaschek G, Prayer D (2006) Magnetic resonance imaging of the normal placenta. Eur J Radiol 57:256–260, DOI 210.1016/j.ejrad.2005.1011.1025 PubMedCrossRef

54.

Predanic M, Perni SC, Chasen S, Chervenak FA (2004) Fetal aneuploidy and umbilical cord thickness measured between 14 and 23 weeks’ gestational age. J Ultrasound Med 23:1177–1183PubMed

55.

Cromi A, Ghezzi F, Durig P, Di Naro E, Raio L (2005) Sonographic umbilical cord morphometry and coiling patterns in twin-twin transfusion syndrome. Prenat Diagn 25:851–855, DOI 810.1002/pd.1273 PubMedCrossRef

56.

Heinonen S, Ryynanen M, Kirkinen P, Saarikoski S (1996) Perinatal diagnostic evaluation of velamentous umbilical cord insertion: clinical, Doppler, and ultrasonic findings. Obstet Gynecol 87:112–117PubMedCrossRef

57.

Sohaey R (1998) Amniotic fluid and the umbilical cord: the fetal milieu and lifeline. Semin Ultrasound CT MR 19:355–369PubMedCrossRef

58.

Zaretsky MV, McIntire DD, Reichel TF, Twickler DM (2004) Correlation of measured amnionic fluid volume to sonographic and magnetic resonance predictions. Am J Obstet Gynecol 191:2148–2153, DOI 2110.1016/j.ajog.2004.2104.2044 PubMedCrossRef

59.

Prayer D, Brugger PC, Krampl E, Prayer L (2006) Indikationen zur fetalen Magnetresonanztomographie. Der Radiologe 46:98–104, DOI 110.1007/s00117-00005-01312-00110 PubMedCrossRef

60.

Graf JL, Bealer JF, Gibbs DL, Adzick NS, Harrison MR (1997) Chorioamniotic membrane separation: a potentially lethal finding. Fetal Diagn Ther 12:81–84PubMedCrossRef

61.

Kato K, Shiozawa T, Ashida T, Unno N, Konishi I (2005) Prenatal diagnosis of amniotic sheets by magnetic resonance imaging. Am J Obstet Gynecol 193:881–884, DOI 810.1016/j.ajog.2005.1002.1111 PubMedCrossRef

62.

Webb JA, Thomsen HS, Morcos SK, (ESUR) MoCMSCoESoUR (2005) The use of iodinated and gadolinium contrast media during pregnancy and lactation. Eur Radiol 15:1234–1240, DOI 1210.1007/s00330-00004-02583-y PubMedCrossRef

63.

Colletti PM, Sylvestre PB (1994) Magnetic resonance imaging in pregnancy. Magn Reson Imaging Clin N Am 2:291–307PubMed

64.

Rofsky NM, Pizzarello DJ, Weinreb JC, Ambrosino MM, Rosenberg C (1994) Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine. J Magn Reson Imaging 4:805–807PubMedCrossRef

65.

Novak Z, Thurmond AS, Ross PL, Jones MK, Thornburg KL, Katzberg RW (1993) Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits. Invest Radiol 28:828–830PubMedCrossRef

66.

Marcos HB, Semelka RC, Worawattanakul S (1997) Normal placenta: gadolinium-enhanced dynamic MR imaging. Radiology 205:493–496PubMed

67.

Vanhaesebrouck P, Verstraete AG, De Praeter C, Smets K, Zecic A, Craen M (2005) Transplacental passage of a nonionic contrast agent. Eur J Pediatr 164:408–410, DOI 410.1007/s00431-00005-01659-00432 PubMedCrossRef

68.

Alexander A, Samlowski WE, Grossman D, Bruggers CS, Harris RM, Zone JJ, Noyes RD, Bowen GM, Leachman SA (2003) Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant. J Clin Oncol 21:2179–2186, DOI 2110.1200/JCO.2003.2112.2149 PubMedCrossRef

69.

Schäffer M, Hegenbart U, Klostermann K, Stepan H (2003) Hodgkin-Lymphom in der Schwangerschaft-Falldarstellung und Literaturübersicht. Z Geburtshilfe Neonatol 207:71–73, DOI 10.1055/s-2003-39153 PubMedCrossRef

70.

Nam KH, Yoon JH, Chang HS, Park CS (2005) Optimal timing of surgery in well-differentiated thyroid carcinoma detected during pregnancy. J Surg Oncol 91:199–203, DOI 110.1002/jso.20327 PubMedCrossRef

71.

Bates SM, Ginsberg JS (2001) Pregnancy and deep vein thrombosis. Semin Vasc Med 1:97–104PubMedCrossRef

72.

Birchard KR, Brown MA, Hyslop WB, Firat Z, Semelka RC (2005) MRI of acute abdominal and pelvic pain in pregnant patients. Am J Roentgenol 184:452–458

73.

Shoenut JP, Semelka RC, Silverman R, Yaffe CS, Micflikier AB (1993) MRI in the diagnosis of Crohn’s disease in two pregnant women. J Clin Gastroenterol 17:244–247PubMedCrossRef

74.

Palacios Jaraquemada JM, Bruno CH (2005) Magnetic resonance imaging in 300 cases of placenta accreta: surgical correlation of new findings. Acta Obstet Gynecol Scand 84:716–724, DOI 710.1111/j.0001-6349.2005.00832.x PubMedCrossRef

75.

Adzick NS, Kitano Y (2003) Fetal surgery for lung lesions, congenital diaphragmatic hernia, and sacrococcygeal teratoma. Semin Pediatr Surg 12:154–167PubMedCrossRef

76.

Barkovich AJ, Latal-Hajnal B, Partridge JC, Sola A, Ferriero DM (1997) MR contrast enhancement of the normal neonatal brain. AJNR Am J Neuroradiol 18:1713–1717PubMed

77.

Huisman TA, Martin E, Kubik-Huch R, Marincek B (2002) Fetal magnetic resonance imaging of the brain: technical considerations and normal brain development. Eur Radiol 12:1941–1951, DOI 1910.1007/s00330-00001-01209-x PubMed

78.

Duncan KR (2001) Fetal and placental volumetric and functional analysis using echo-planar imaging. Top Magn Reson Imaging 12:52–66PubMedCrossRef

Title: Investigation of normal organ development with fetal MRI
Authors: Daniela Prayer
Peter C. Brugger
Publication date: 01-10-2007
Publisher: Springer-Verlag
Published in: European Radiology / Issue 10/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-007-0604-3

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Springer Medicine

Investigation of normal organ development with fetal MRI

Abstract

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Abstract

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