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BMC Psychiatry
Published in: BMC Psychiatry 1/2015

Open Access 01-12-2015 | Study protocol

Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial

Authors: Marieke E van Der Schaaf, Iris C Schmits, Megan Roerink, Dirk EM Geurts, Ivan Toni, Karin Roelofs, Floris P De Lange, Urs M Nater, Jos WM van der Meer, Hans Knoop

Published in: BMC Psychiatry | Issue 1/2015

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Abstract

Background

Chronic fatigue syndrome (CFS) is characterized by profound and disabling fatigue with no known somatic explanation. Cognitive behavioral therapy (CBT) has proven to be a successful intervention leading to a reduction in fatigue and disability. Based on previous neuroimaging findings, it has been suggested that central neural mechanisms may underlie CFS symptoms and play a role in the change brought on by CBT. In this randomized controlled trial we aim to further investigate the neural mechanisms that underlie fatigue in CFS and their change by CBT.

Methods/Design

We will conduct a randomized controlled trial in which we collect anatomical and functional magnetic resonance imaging (MRI) measures from female CFS patients before and after CBT (N = 60) or waiting list (N = 30) and compare these with measures from age and education matched healthy controls (N = 30). By including a large treatment group we will also be able to compare patients that benefit from CBT with those that do not. In addition, to further investigate the role of endocrine and immune biomarkers in CFS, we will determine cortisol and cytokine concentrations in blood, hair and/or saliva.

Discussion

This project creates an unique opportunity to enhance our understanding of CFS symptoms and its change by CBT in terms of neuroanatomical, neurofunctional, endocrinological and immunological mechanisms and can help to further improve future treatments strategies.

Trial registration

Dutch Trial Register #15852. Registered 9 December 2013 (http://​www.​trialregister.​nl/​trialreg/​admin/​rctview.​asp?​TC=​4311)
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Metadata
Title
Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial
Authors
Marieke E van Der Schaaf
Iris C Schmits
Megan Roerink
Dirk EM Geurts
Ivan Toni
Karin Roelofs
Floris P De Lange
Urs M Nater
Jos WM van der Meer
Hans Knoop
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2015
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-015-0515-9

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