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01-02-2019 | Oncology

Intravoxel incoherent motion diffusion-weighted imaging for assessment of histologic grade of hepatocellular carcinoma: comparison of three methods for positioning region of interest

Authors: Yi Wei, Feifei Gao, Min Wang, Zixing Huang, Hehan Tang, Jiaxing Li, Yi Wang, Tong Zhang, Xiaocheng Wei, Dandan Zheng, Bin Song

Published in: European Radiology | Issue 2/2019

Abstract

Objectives

To prospectively compare the diagnostic performances of three methods of region of interest (ROI) placement for the measurements of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in differentiating the histologic grade of hepatocellular carcinoma (HCC).

Methods

Eighty-seven patients with 91 newly diagnosed HCCs were studied using IVIM imaging. Two attending radiologists separately identified the selection of tumour tissue for ROI positioning. Three different ROI positioning methods, namely the whole tumour volume (WTV) method, three-ROI method and one-section method, were used for the measurement. Kruskal–Wallis rank test or one-way ANOVA was used to compare the difference in IVIM parameters and ADC across the three different ROI positioning methods. Spearman correlation analysis was used to determine the correlation between each parameter and Edmondson–Steiner (E–S) grade. Receiver operating characteristics (ROC) curve analyses were performed to evaluate the diagnostic performance.

Results

For the ADC and ADC_slow, the mean value measured by using the WTV method was significant higher than the one-section and three-ROI methods (all p < 0.01). For the ADC_slow, the highest area under curve (AUC) with a value of 0.969 was obtained by using the WTV method, followed by the one-section method (AUC = 0.938) and three-ROI method (AUC = 0.873). Additionally, for the ADC, AUC values were 0.861 for WTV method, 0.840 for one-section method and 0.806 for three-ROI method.

Conclusions

Different ROI positioning methods used significantly affect the IVIM parameters and ADC measurements. Measurements of ADC_slow value derived from WTV method entailed the highest diagnostic performance in grading HCC.

Key Points

• Diffusion MRI is useful for non-invasively differentiating the histologic grade of hepatocellular carcinoma.

• Different ROI positioning methods used significantly affect the IVIM parameters and ADC measurements.

• IVIM model is advantageous over mono-exponential model for assessing the histologic grade of hepatocellular carcinoma.

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Title: Intravoxel incoherent motion diffusion-weighted imaging for assessment of histologic grade of hepatocellular carcinoma: comparison of three methods for positioning region of interest
Authors: Yi Wei
Feifei Gao
Min Wang
Zixing Huang
Hehan Tang
Jiaxing Li
Yi Wang
Tong Zhang
Xiaocheng Wei
Dandan Zheng
Bin Song
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5638-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intravoxel incoherent motion diffusion-weighted imaging for assessment of histologic grade of hepatocellular carcinoma: comparison of three methods for positioning region of interest

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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