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Dysphagia
Published in: Dysphagia 1/2004

01-01-2004 | Editorial

Intravenous Glucagon in Food Impaction—Use It or Lose It?

Authors: Ronnie Fass, MD, Roy Dekel, MD

Published in: Dysphagia | Issue 1/2004

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Excerpt

The efficacy of intravenous glucagon in relieving acute esophageal food impaction has been questioned repeatedly in the literature. Less than a decade ago, in this journal, Maglinte [1] raised the question of whether we should abandon pharmacologic disimpaction of lower esophageal foreign bodies. He concluded that pharmacologic disimpaction is a reasonable, efficient, safe, and cost-effective first line management of food impaction and thus should be continued. Unfortunately, data to support the usage of glucagon in food impaction remained relatively scarce and large double blind, placebo-controlled trials are still lacking. …
Literature
1.
Maglinte, DD 1995Editorial: Pharmacoradiologic disimpaction of lower esophageal foreign bodies: should we abandon it?Dysphagia10128130PubMed
2.
Hall–Boyer, K, Zaloga, GP, Chernow, B 1984Glucagon: hormone or therapeutic agent?Crit Care Med12584589PubMed
3.
Feczko, PJ, Haggar, AM, Halpert, RD 1985A reappraisal of upper gastrointestinal response to low-dose glucagon.Crit Rev Diagn Imaging23377412PubMed
4.
Christiansen, J, Borgeskov, S 1974The effect of glucagon and the combined effect of glucagon and secretin on lower esophageal sphincter pressure in man.Scand J Gastroenterol9615618PubMed
5.
Jaffer, SS, Makhlouf, GM, Schorr, BA, Zfass, AM 1974Nature and kinetics of inhibition of lower esophageal sphincter pressure by glucagon.Gastroenterology674246PubMed
6.
Moosa, AR, Hall, AW, Hughes, RG, Moraldi, A, Moosa, DE, Skinner, DB 1978Effect of gastrointestinal hormone infusions of lower oesophageal competence of rhesus monkeys.Br J Surg65499504PubMed
7.
Hogan, WJ, Dodds, WJ, Hoke, SE, Reid, DP, Kalkhoff, RK, Amdorfer, RC 1975Effect of glucagon on esophageal motor function.Gastroenterology69160165PubMed
8.
Channer, KS, Bolton, R, Al-Hilli, S, Nakielny, R, Virjee, JP 1983The effect of glucagon on the swallowing of capsules.Br J Clin Pharmacol16456458PubMed
9.
Anvair, M, Richards, D, Dent, J, Waterfall, WE, Stevenson, GW 1989The effect of glucagon on esophageal peristalsis and clearance.Gastrointest Radiol14100102PubMed
10.
Ferrucci, JT Jr, Long, JA Jr 1977Radiologic treatment of esophageal food impaction using intravenous glucagon.Radiology1252528PubMed
11.
Glauser, J, Lilja, GP, Greenfeld, B, Ruiz, E 1979Intravenous glucagon in the management of esophageal food obstruction.JACEP8228231PubMed
12.
Handal, KA, Riordan, W, Siese, J 1980The lower esophagus and glucagon.Ann Emerg Med9557579PubMed
13.
Trenkner, SW, Maglinte, DD, Lehman, GA, Chernish, SM, Miller, RE, Johnson, CW 1983Esophageal food impaction: treatment with glucagon.Radiology149401403PubMed
14.
Bryant, BG, Trout, DJ 1982Treatment of esophageal food impaction—a new use for glucagon.Drug Intell Clin Pharm16407409PubMed
15.
Robbins, MI, Shortsleeve, MJ 1994Treatment of acute esophageal food impaction with glucagon, effervescent agent, and water.AJR Am J Roentgenol162325328
16.
Tibbling, L, Bjorkhoel, A, Jansson, E, Stenkvist, M 1995Effect of spasmolytic drugs on esophageal foreign bodies.Dysphagia10126127PubMed
17.
Mehta, D, Attia, M, Quintana, E, Cronan, K 2001Glucagon use for esophageal coin dislodgment in children: A prospective, double-blind, placebo-controlled trial.Acad Emerg Med8200203PubMed
18.
Sodeman, TC, Harewood, GC, Baron, TH 2004Assessment of the predictors of response to glucagon in the setting of acute esophageal food bolus impaction.Dysphagia191821CrossRefPubMed
19.
Longstreth, GF, Longstreth, KJ, Yao, JF 2001Esophageal food impaction: epidemiology and therapy. A retrospective, observational study.Gastrointest Endosc53193198CrossRefPubMed
20.
Colon, V, Grade, A, Pulliam, G, Johnson, C, Fass, R 1999Effect of doses of glucagon used to treat food impaction on esophageal motor function of normal subjects.Dysphagia142730PubMed
21.
Alaradi, O, Bartholomew, M, Barkin, JS 2001Upper endoscopy and glucagon: A new technique in the management of acute esophageal food impaction.Am J Gastroenterol96912913CrossRefPubMed
Metadata
Title
Intravenous Glucagon in Food Impaction—Use It or Lose It?
Authors
Ronnie Fass, MD
Roy Dekel, MD
Publication date
01-01-2004
Publisher
Springer-Verlag
Published in
Dysphagia / Issue 1/2004
Print ISSN: 0179-051X
Electronic ISSN: 1432-0460
DOI
https://doi.org/10.1007/s00455-003-0024-8

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