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Journal of Cardiovascular Translational Research

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13-07-2023 | Intravascular Ultrasound | Original Article

Intravascular Ultrasound-Based Fractional Flow Reserve for Predicting Prognosis after Percutaneous Coronary Intervention

Authors: Jianzhen Huang, Xinyi Yang, Yumeng Hu, Huibin Li, Xiaochang Leng, Jianping Xiang, Wenjuan Wei

Published in: Journal of Cardiovascular Translational Research | Issue 6/2023

Abstract

AccuFFRivus is an alternative to fractional flow reserve (FFR) based on intravascular ultrasound (IVUS) images for functional assessment of coronary stenosis. However, its prognostic impact in patients undergoing percutaneous coronary intervention (PCI) is still unclear. This retrospective study aimed to investigate the capability of AccuFFRivus in predicting prognosis. AccuFFRivus was calculated based on postoperative angiographic and IVUS images. Vessel-oriented clinical events (VOCE) at 2 years were recorded and analyzed. A total of 131 participants with 131 vessels were included in the study. VOCE occurred in 15 patients during 2-year follow-up. AccuFFRivus after PCI (post-AccuFFRivus) was significantly higher in the non-VOCE group than in the VOCE group (0.95 ± 0.03 vs. 0.91 ± 0.02, p < 0.001). Multivariate Cox regression showed that AccuFFRivus ≤ 0.94 was a strong independent predictor of VOCE during 2-year follow-up (hazard ratio 23.76, 95% confidence interval: 3.04–185.81, p < 0.001).

Graphical Abstract

The left panel displays the Receiver operating characteristics (ROC) curves of postoperative parameters (post-AccuFFRivus and post-MLA) versus vessel-oriented clinical events (VOCE) occurrence within 2-year follow-up. The right panel demonstrates Kaplan–Meier curves of VOCE stratified by the optimal cut-off of post-AccuFFRivus.

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Title: Intravascular Ultrasound-Based Fractional Flow Reserve for Predicting Prognosis after Percutaneous Coronary Intervention
Authors: Jianzhen Huang
Xinyi Yang
Yumeng Hu
Huibin Li
Xiaochang Leng
Jianping Xiang
Wenjuan Wei
Publication date: 13-07-2023
Publisher: Springer US
Keywords: Intravascular Ultrasound
Myocardial Infarction
Angiography
Published in: Journal of Cardiovascular Translational Research / Issue 6/2023
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-023-10409-2

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Springer Medicine

Intravascular Ultrasound-Based Fractional Flow Reserve for Predicting Prognosis after Percutaneous Coronary Intervention

Abstract

Graphical Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Graphical Abstract

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