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Journal of Assisted Reproduction and Genetics

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01-01-2009 | ASSISTED REPRODUCTION

Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome

Authors: Shahrzad Zadehmodarres, Belgheis Oladi, Shahrbanoo Saeedi, Fatemeh Jahed, Haleh Ashraf

Published in: Journal of Assisted Reproduction and Genetics | Issue 1/2009

Abstract

Purpose

The aim was to determine pregnancy rate following intrauterine insemination (IUI) and its associated factors in a university assisted reproductive technique center in Tehran, Iran.

Methods

A retrospective analysis of 350 IUI cycles with ovarian stimulation by clomiphene citrate and/or gonadotropins was performed.

Results

The overall pregnancy rate was 22% (77/350). Of the 77 pregnancies, 88.3% resulted in live birth, 7.8% in spontaneous abortion, 2.6% in blighted ovum and 1.3% were ectopic. Logistic regression analysis revealed three predictive variables as regards pregnancy: number of the treatment cycle (OR:3.5 CI:1.9 – 6.4 p:0.006), duration of infertility (OR:2.1 CI:1.2 – 3.7 p = 0.001) and age (OR:2.15 CI:1.1 – 4.4 p = 0.04). Pregnancy rate did not have any independent relation to sperm count, type of infertility, number and size of follicle and side of ovulatory ovary.

Conclusion

Our results indicate that clomiphene citrate and/or gonadotropins IUI is a convenient and useful treatment option in women with younger age ( <30 years) and fewer treatment cycles and fewer infertility duration (4 years).

Kossakowski J, Stephenson M, Smith H. Intrauterine insemination with husband’s sperm: comparison of pregnancy rates in couples with cervical factor, male factor, immunological factor and idiopathic infertility. Aust N Z J Obstet Gynaecol 1993;33:183–6. doi:10.1111/j.1479-828X.1993.tb02389.x.PubMedCrossRef

Ibérico G, Vioque J, Ariza N, Lozano JM, Roca M, Llácer J, et al. Analysis of factors influencing pregnancy rates in homologous intrauterine insemination. Fertil Strel 2004;81:1308–13. doi:10.1016/j.fertnstert.2003.09.062.CrossRef

Paulmyer-Lacroix O, Molle L, Noizet A, Guérin A, Mollar M, Gamerre M, et al. Intrauterine insemination with the husband’s sperm: conclusions of five years experience. Contracept Fertil Sex 1998;26:300–6.PubMed

The European IVF-monitoring programme (EIM) for the European Society of Human Reproduction and Embryology (ESHRE), Andersen AN, Gianaroli L, Felberbaum R, de Mouzon J, Nygren KG: Assisted reproductive technology in Europe, 2002. Results generated from European registers by ESHRE. Hum Reprod. 2006;21:1680–97. doi:10.1093/humrep/del075.

Allen NC, Herbert CM 3rd, Maxson WS, Rogers BJ, Diamond MP, Wentz AC. Intrauterine insemination: a critical review. Fertil Steril 1985;44:569–80.PubMed

Sinikka NH, Candido T, Risto B, Leena T, Hannu M. Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Hum Reprod 1999;14:698–703. doi:10.1093/humrep/14.3.698.CrossRef

Awonuga A, Govindbhai J. Is waiting for endogenous luteinizing hormone surge and/or administration of human chorionic gonadotrophin of benefit in intrauterine insemination? Hum Reprod 1999;14:765–70. doi:10.1093/humrep/14.7.1765.CrossRef

Gezginç K, Görkemli H, Celik C, Karatayli R, Ciçek MN, Olakoglu MC. Comparison of single versus double intrauterine insemination. Taiwan J Obstet Gynecol 2008;7:57–61.CrossRef

Demirol A, Gurgan T. Comparison of different gonadotrophin preparations in intrauterine insemination cycles for the treatment of unexplained infertility: a prospective, randomized study. Hum Reprod 2007;22:97–100. doi:10.1093/humrep/del335.PubMedCrossRef

10.

Freour T, Jean M, Mirallie S, Langlois ML, Dubourdieu S, Barriere P. Predictive value of CASA parameters in IUI with frozen donor sperm. Int J Androl. 2008; Epub ahead of print.

11.

World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. 2nd ed. Cambridge, UK: Cambridge University Press; 1987.

12.

Hwang JL, Huang LW, Hsieh BCH, Tsai YL, Huang SHC, Chen CHY, Hsieh ML, Chen PH Lin YH. Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles. Human Reproduction 2003;18:45–9.PubMedCrossRef

13.

Cantineau AEP, Cohlen BJ, Heineman MJ. Ovarian stimulation protocols (anti-oestrogens, gonadotrophins with and without GnRH agonists/antagonists) for intrauterine insemination (IUI) in women with subfertility. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD005356.

14.

Mathieu C, Ecochard R, Bied V, Lornage J, Czyba JC. Cumulative conception rate following intrauterine artificial insemination with husband’s spermatozoa: influence of husband’s age. Hum Reprod 1995;10:1090–7.PubMed

15.

Sato H, Kaneko S, Kobayashi T, Oda T, Ohno T, Lizuka R. Improved semen qualities after continuous step density gradient centrifugation: application to artificial insemination and pregnancy outcome. Arch Androl 1990;24:87–93. doi:10.3109/01485019008986863.PubMedCrossRef

16.

Tredway DR, Chan P, Henig I, Gulett A, Cheatwood M. Effectiveness of stimulated menstrual cycles and Percoll sperm preparation in intrauterine insemination. J Reprod Med 1990;35:103–8.PubMed

17.

Scemama H, Salat-Baroux J, Antoine JM, Saada H, Cohen-Bacrie P. L’hyperstimulation controlee du cycle associee a une insemination intrauterine de sperme migre du conjoint. Gynecologic 1993;1:125–31.

18.

Wang B, Hu Y, Sun H, Zhang N, Xu Z. Investigation of correlative factors affecting successful intrauterine insemination. Zhonghua Nan Ke Xue 2004;10:526–9.PubMed

19.

Frederick JL, Denker MS, Rojas A, Horta I, Stone SC, Asch RH, et al. Is there a role for ovarian stimulation and intra-uterine insemination after age 40? Hum Reprod 1994;9:2284–6.PubMed

20.

Corsan G, Trias A, Trout S, Kemmann E. Ovulation induction combined with intrauterine insemination in women 40 years of age and older: is it worthwhile? Hum Reprod 1996;11:1109–12.PubMed

21.

Kang BM, Wu TC. Effect of age on intrauterine insemination with frozen donor sperm. Obstet Gynecol 1996;88:93–8. doi:10.1016/0029-7844(96)00074-9.PubMedCrossRef

22.

Abdalla HI, Burton G, Kirkland A, Johnson MR, Leonard T, Brooks AA, et al. Age, pregnancy and miscarriage: uterine versus ovarian factors. Hum Reprod 1993;8:1512–7.PubMed

23.

Cano F, Simon C, Remohi J, Pellicer A. Effect of aging on the female reproductive system: evidence for a role of uterine senescence in the decline in female fecundity. Fertil Steril 1995;64:584–9.PubMed

24.

Dickey RP, Olar TT, Taylor SN, Curole DN, Rye PH. Relationship of follicle number and other factors to fecundability and multiple pregnancy in clomiphene citrate-induced intrauterine insemination cycles. Fertil Steril 1992;57:613–9.PubMed

25.

Botchan A, Hauser R, Gamzu R, Yogev L, Paz G, Yavetz H. Results of 6139 artificial insemination cycles with donor spermatozoa. Hum Reprod 2001;16:2298–304. doi:10.1093/humrep/16.11.2298.PubMedCrossRef

26.

Plosker SM, Jacobson W, Amato P. Predicting and optimizing success in an intra-uterine insemination programme. Hum Reprod 1994;9:2014–21.PubMed

27.

Nuojua-Huttunen S, Tomas C, Bloigu R, Tuomivaara L, Martikainen H. Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Hum Reprod 1999;14:698–703. doi:10.1093/humrep/14.3.698.PubMedCrossRef

28.

American Society for Reproductive Medicine Assisted reproductive technology in the United States and Canada: 1993 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1995;64:13–21.

Title: Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome
Authors: Shahrzad Zadehmodarres
Belgheis Oladi
Shahrbanoo Saeedi
Fatemeh Jahed
Haleh Ashraf
Publication date: 01-01-2009
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 1/2009
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-008-9273-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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