Intratumoral Gene Therapy Injections with a Multipronged, Multi–Side Hole Needle for Rectal Carcinoma

Excerpt

Interventional radiologists can deliver therapeutics directly to a tumor via needle injection. One of the major limitations of directly injected gene therapies is limited delivery, penetration, and transfection efficiency of the genetic vector, which in many cases directly limits the therapeutic effect. Several preclinical oncology models exist that rely on direct injection of DNA plasmid or vector through an end-hole needle and into a tumor. Selection of a physically more efficient device with more needles and more side holes could improve distribution of the therapeutic agent [1]. Small hepatocellular carcinomas have been effectively treated with alcohol injections via a multipronged, multi–side hole needle [2]. …