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01-05-2010 | Case Report

Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination

Authors: Maria Grazia Passarin, Giuseppe Moretto, Anna Maria Musso, Sarah Ottaviani, Barbara Masotto, Claudio Ghimenton, Paolo Iuzzolino, Ebba Buffone, Roberta Rudà, Riccardo Soffietti, Emanuela Vattemi, Rebecca Pedersini

Published in: Journal of Neuro-Oncology | Issue 3/2010

Abstract

Leptomeningeal dissemination of low-grade gliomas is an uncommon event. A 43-year old male presented with dizziness, gait ataxia, and diplopia. A nonenhancing lesion in the right cerebellar peduncle was identified, subtotally resected, and diagnosed as a grade II astrocytoma. After one year a nodular spread in the brain and leptomeninges was diagnosed, so the patient started chemotherapy with temozolomide and liposomal cytarabine. Complete remission was achieved after 12 months of treatment and the patient is still free from the disease after a follow-up of 24 months. We suggest that this combination may be a valuable treatment option.

Grier JT, Batchelor T (2006) Low-grade gliomas in adults. Oncologist 11:681–693CrossRefPubMed

Arita N, Taneda M, Hayakawa T (1994) Leptomeningeal dissemination of malignant gliomas. Incidence, diagnosis and outcome. Acta Neurochir (Wien) 126:84–92CrossRef

Pollack IF, Hurtt M, Pang D, Albright AL (1994) Dissemination of low grade intracranial astrocytomas in children. Cancer 73:2869–2878CrossRefPubMed

D’Haene N, Coen N, Neugroschl C, Balériaux D, Salmon I (2009) Leptomeningeal dissemination of low-grade intramedullary gliomas: about one case and review. Clin Neurol Neurosurg 111:390–394CrossRefPubMed

Hukin J, Siffert J, Velasquez L, Zagzag D, Allen J (2002) Leptomeningeal dissemination in children with progressive low-grade neuroepithelial tumors. Neuro Oncol 4:253–260CrossRefPubMed

Chamberlain MC (2005) Neoplastic meningitis. J Clin Oncol 23:3605–3613CrossRefPubMed

Brada M, Viviers L, Abson C, Hines F, Britton J, Ashley S et al (2003) Phase II study of primary temozolomide chemotherapy in patients with WHO grade II gliomas. Ann Oncol 14:1715–1721CrossRefPubMed

Hoang-Xuan K, Capelle L, Kujas M, Taillibert S, Duffau H, Lejeune J et al (2004) Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions. J Clin Oncol 22:3133–3138CrossRefPubMed

Quinn JA, Reardon DA, Friedman AH, Rich JN, Sampson JH, Provenzale JM et al (2003) Phase II trial of temozolomide in patients with progressive low-grade glioma. J Clin Oncol 21:646–651CrossRefPubMed

10.

Ostermann S, Csajka C, Buclin T, Leyvraz S, Lejeune F, Decosterd LA (2004) Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients. Clin Cancer Res 10(11):3728–3736CrossRefPubMed

11.

Murry DJ, Blaney SM (2000) Clinical pharmacology of encapsulated sustained-release cytarabine. Ann Pharmacother 34:1173–1178CrossRefPubMed

12.

Chamberlain MC, Kormanik P, Howell SB, Kim S (1995) Pharmacokinetics of intralumbar DTC-101 for the treatment of leptomeningeal metastases. Arch Neurol 52:912–917PubMed

13.

Jaeckle KA, Batchelor T, O’Day SJ, Phuphanich S, New P, Lesser G et al (2002) An open label trial of sustained-release cytarabine (DepoCyt) for the intrathecal treatment of solid tumor neoplastic meningitis. J Neurooncol 57:231–239CrossRefPubMed

14.

Glantz MJ, Jaeckle KA, Chamberlain MC, Phuphanich S, Recht L, Swinnen LJ et al (1999) A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res 5:3394–3402PubMed

15.

Lassaletta A, Perez-Olleros P, Scaglione C, Sirvent S, De Prada I, Perez-Martinez A et al (2007) Successful treatment of intracranial ependymoma with leptomeningeal spread with systemic chemotherapy and intrathecal liposomal cytarabine in a two-year-old child. J Neurooncol 83(3):303–306CrossRefPubMed

Title: Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination
Authors: Maria Grazia Passarin
Giuseppe Moretto
Anna Maria Musso
Sarah Ottaviani
Barbara Masotto
Claudio Ghimenton
Paolo Iuzzolino
Ebba Buffone
Roberta Rudà
Riccardo Soffietti
Emanuela Vattemi
Rebecca Pedersini
Publication date: 01-05-2010
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2010
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-009-0040-0

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Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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